SIRT1 transgenic mice show phenotypes resembling calorie restriction
Summary We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice dis...
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| Published in | Aging cell Vol. 6; no. 6; pp. 759 - 767 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.12.2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1474-9718 1474-9726 1474-9726 |
| DOI | 10.1111/j.1474-9726.2007.00335.x |
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| Abstract | Summary
We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie‐restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity. |
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| AbstractList | Summary
We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie‐restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity. We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are hemizygous for this transgene express normal levels of beta-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity. We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are hemizygous for this transgene express normal levels of beta-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are hemizygous for this transgene express normal levels of beta-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity. We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie‐restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity. |
| Author | Van Veen, Ed Luo, Jianyuan Cohen, Dena Motta, Maria Carla Czopik, Agnieszka Gu, Wei Guarente, Leonard Crowe, Hayley Marmor, Stephen Steele, Andrew D. Bordone, Laura Robinson, Ashley |
| Author_xml | – sequence: 1 givenname: Laura surname: Bordone fullname: Bordone, Laura – sequence: 2 givenname: Dena surname: Cohen fullname: Cohen, Dena – sequence: 3 givenname: Ashley surname: Robinson fullname: Robinson, Ashley – sequence: 4 givenname: Maria Carla surname: Motta fullname: Motta, Maria Carla – sequence: 5 givenname: Ed surname: Van Veen fullname: Van Veen, Ed – sequence: 6 givenname: Agnieszka surname: Czopik fullname: Czopik, Agnieszka – sequence: 7 givenname: Andrew D. surname: Steele fullname: Steele, Andrew D. – sequence: 8 givenname: Hayley surname: Crowe fullname: Crowe, Hayley – sequence: 9 givenname: Stephen surname: Marmor fullname: Marmor, Stephen – sequence: 10 givenname: Jianyuan surname: Luo fullname: Luo, Jianyuan – sequence: 11 givenname: Wei surname: Gu fullname: Gu, Wei – sequence: 12 givenname: Leonard surname: Guarente fullname: Guarente, Leonard |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17877786$$D View this record in MEDLINE/PubMed |
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| Snippet | Summary
We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that... We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are... We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are... We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta -actin locus. Mice that are... |
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| SubjectTerms | Adipokines - blood Animals Blood Glucose - analysis Caloric Restriction calorie restriction Cholesterol - blood Insulin - blood Longevity - genetics Mice Mice, Transgenic Phenotype SIRT1 Sirtuin 1 Sirtuins - genetics Sirtuins - metabolism transgenic mice Up-Regulation |
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| Title | SIRT1 transgenic mice show phenotypes resembling calorie restriction |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1474-9726.2007.00335.x https://www.ncbi.nlm.nih.gov/pubmed/17877786 https://www.proquest.com/docview/19899099 https://www.proquest.com/docview/68512087 |
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