Premotor Parkinson's disease: Concepts and definitions

• Published in: Movement disorders Vol. 27; no. 5; pp. 608 - 616
• Main Authors: Siderowf, Andrew, Lang, Anthony E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.04.2012
• Subjects: early detection; Early Diagnosis; Humans; Motor Neurons - pathology; Parkinson Disease - classification; Parkinson Disease - diagnosis; Parkinson Disease - etiology; Parkinson Disease - genetics; Parkinson Disease - therapy; Parkinson's disease; sensitivity; specificity

Parkinson's disease (PD) has a prodromal phase during which nonmotor clinical features as well as physiological abnormalities may be present. These premotor markers could be used to screen for PD before motor abnormalities are present. The technology to identify PD before it reaches symptomatic...