Some biological features of Candida albicans mutants for genes coding fungal proteins containing the CFEM domain

• Published in: FEMS yeast research Vol. 11; no. 3; pp. 273 - 284
• Main Authors: Pérez, Ana, Ramage, Gordon, Blanes, Rosario, Murgui, Amelia, Casanova, Manuel, Martínez, José P
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2011; Oxford University Press
• Subjects: Animal models; Animals; Atomic force microscopy; biofilm; Biofilms; Biofilms - growth & development; Candida albicans; Candida albicans - chemistry; Candida albicans - genetics; Candida albicans - metabolism; Candida albicans - physiology; Cell surface; cell surface hydrophobicity; Cell viability; cells; Clonal deletion; Concanavalin A; confocal laser scanning microscopy; dyes; Extracellular matrix; fluorescence; Fluorescent indicators; Fungal cell surface proteins; fungal proteins; Fungal Proteins - chemistry; Fungal Proteins - genetics; Fungal Proteins - metabolism; Gene expression; gene expression regulation; Gene Expression Regulation, Fungal; genes; Genes, Fungal - genetics; glucose; Green Fluorescent Proteins; Hydrophobic and Hydrophilic Interactions; Hydrophobicity; Mannose; Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Microscopy; Microscopy, Atomic Force; Microscopy, Confocal; Mutants; Mutation; Mycelia; mycelium; PGA10; pleiotropy; polypeptides; Promoter Regions, Genetic - genetics; Protein Structure, Tertiary; Proteins; RBT5 and CSA1/WAP1 genes; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Virulence; yeasts; Fungal cell surface proteins; atomic force microscopy; genes; cell surface hydrophobicity; biofilms; and

Several biological features of Candida albicans genes (PGA10, RBT5 and CSA1) coding for putative polypeptide species belonging to a subset of fungal proteins containing an eight-cysteine domain referred as common in several fungal extracellular membrane (CFEM) are described. The deletion of these ge...