The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

• Published in: Experimental dermatology Vol. 23; no. 1; pp. 45 - 52
• Main Authors: van Smeden, Jeroen, Janssens, Michelle, Kaye, Edward C. J., Caspers, Peter J., Lavrijsen, Adriana P., Vreeken, Rob J., Bouwstra, Joke A.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.01.2014
• Subjects: Adult; atopic eczema; Case-Control Studies; Ceramides - chemistry; Ceramides - metabolism; Cholesterol - metabolism; Dermatitis, Atopic - genetics; Dermatitis, Atopic - metabolism; Epidermis - metabolism; Fatty Acids, Nonesterified - chemistry; Fatty Acids, Nonesterified - metabolism; Female; Humans; Intermediate Filament Proteins - genetics; lipid chain length; Lipid Metabolism; lipid organization; lipids; Male; Mutation; Skin - metabolism; skin barrier function; Spectroscopy, Fourier Transform Infrared; Young Adult; lipids; lipid organization; skin barrier function; lipid chain length; atopic eczema

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids – comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol – fulfil a predominant role in the skin barrier function. In this clinical study, the carbon chain length distribu...