Genetic epidemiology and heritability of AIS: A study of 415 Chinese female patients

• Published in: Journal of orthopaedic research Vol. 30; no. 9; pp. 1464 - 1469
• Main Authors: Tang, Nelson L.S., Yeung, Hiu-Yan, Hung, Vivian W.Y., Di Liao, Chen, Lam, Tsz-Ping, Yeung, Hau-Man, Lee, Kwong-Man, Ng, Bobby Kin-Wah, Cheng, Jack Chun-Yiu
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2012
• Subjects: Adolescent; adolescent idiopathic scoliosis (AIS); Asian Continental Ancestry Group; Case-Control Studies; Child; China - epidemiology; Female; Genetic Predisposition to Disease; heritability; Humans; Male; Scoliosis - epidemiology; Scoliosis - genetics; sibling recurrent risk; China

Recent familial segregation studies supported a multifactorial genetic model for the etiology of adolescent idiopathic scoliosis (AIS). However, the extent of quantitative genetic effects, such as heritability, have not been fully evaluated. This genetic epidemiology study examined the sibling recur...