Relationship between muscarinic M1 receptor binding and cognition in medication-free subjects with psychosis

• Published in: NeuroImage clinical Vol. 18; pp. 713 - 719
• Main Authors: Bakker, Geor, Vingerhoets, Claudia, Boucherie, Daphne, Caan, Matthan, Bloemen, Oswald, Eersels, Jos, Booij, Jan, van Amelsvoort, Thérèse
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 2018; Elsevier
• Subjects: Regular

It is still unclear which underlying mechanisms are involved in cognitive deficits of psychotic disorders. Pro-cognitive effects of muscarinic M1 receptor agonists suggest alterations in M1 receptor functioning may modulate these symptoms. Post mortem studies in patients with schizophrenia have show...