Polarized transport of membrane and secreted proteins during lumen morphogenesis

• Published in: Seminars in cell & developmental biology Vol. 133; pp. 65 - 73
• Main Authors: Levic, Daniel S., Bagnat, Michel
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.01.2023
• Subjects: Animals; Cell Membrane - metabolism; Cell Polarity - physiology; Epithelial; Epithelial Cells - metabolism; Epithelium; Fluid secretion; Lumen; Morphogenesis; Morphogenesis - physiology; Polarity; Proteins - metabolism; Zebrafish; GPI; VIPR1; Na+/K+-ATPase; AMIS; aPKC; CHO; cAMP; CDC42; Morphogenesis; CG5789; Cse1l; SJ; Polarity; MDCK; Fluid secretion; CD34; COP-1; Ch-LD; ABCC4; NHERF1; PDZ; PKA; Lumen; AJ; GEF; Nkcc1; Zebrafish; KV; PDZK1; CHEs; SMG; ER; ECM; AP; Par6; ZO-1; Cldn15la; Par3; TGN; V-H+ ATPase; Anxa2; Tcf2; VIP; Ehbp1; CFTR; Epithelial

A ubiquitous feature of animal development is the formation of fluid-filled cavities or lumina, which transport gases and fluids across tissues and organs. Among different species, lumina vary drastically in size, scale, and complexity. However, all lumen formation processes share key morphogenetic...