A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity
Kinesin-8 motors regulate the size of microtubule structures, using length-dependent accumulation at the plus end to preferentially disassemble long microtubules. Despite extensive study, the kinesin-8 depolymerase mechanism remains under debate. Here, we provide evidence for an alternative, tubulin...
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Published in | Developmental cell Vol. 42; no. 1; pp. 37 - 51.e8 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
10.07.2017
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Abstract | Kinesin-8 motors regulate the size of microtubule structures, using length-dependent accumulation at the plus end to preferentially disassemble long microtubules. Despite extensive study, the kinesin-8 depolymerase mechanism remains under debate. Here, we provide evidence for an alternative, tubulin curvature-sensing model of microtubule depolymerization by the budding yeast kinesin-8, Kip3. Kinesin-8/Kip3 uses ATP hydrolysis, like other kinesins, for stepping on the microtubule lattice, but at the plus end Kip3 undergoes a switch: its ATPase activity is suppressed when it binds tightly to the curved conformation of tubulin. This prolongs plus-end binding, stabilizes protofilament curvature, and ultimately promotes microtubule disassembly. The tubulin curvature-sensing model is supported by our identification of Kip3 structural elements necessary and sufficient for plus-end binding and depolymerase activity, as well as by the identification of an α-tubulin residue specifically required for the Kip3-curved tubulin interaction. Together, these findings elucidate a major regulatory mechanism controlling the size of cellular microtubule structures.
•A tubulin binding switch enables length-dependent microtubule disassembly by Kip3•Tubulin binding suppresses Kip3 ATPase activity, promoting depolymerase activity•Loop11 sequence in Kip3 is necessary and sufficient for curved tubulin binding•Kip3 disassembly-resistant microtubules support the two-state binding switch model
Kinesin-8s promote length-dependent microtubule disassembly. Arellano and colleagues define a mechanism for Kip3/kinesin-8 depolymerization that involves a tubulin curvature-sensing binding switch. They propose that high affinity curved tubulin binding, which is accompanied by suppressed ATPse activity, enables its depolymerase activity. This Kip3 binding switch is thus central to Kip3’s ability to selectively trim long microtubules, narrowing the length distribution of microtubules in cells. |
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AbstractList | Kinesin-8 motors regulate the size of microtubule structures, using length-dependent accumulation at the plus-end to preferentially disassemble long microtubules. Despite extensive study, the kinesin-8 depolymerase mechanism remains under debate. Here, we provide evidence for an alternative, tubulin curvature-sensing model of microtubule depolymerization by the budding yeast kinesin-8, Kip3. Kinesin-8/Kip3 uses ATP hydrolysis, like other kinesins, for stepping on the microtubule lattice, but at the plus-end, Kip3 undergoes a switch: Its ATPase activity is suppressed when it binds tightly to the curved conformation of tubulin. This prolongs plus-end binding, stabilizes protofilament curvature, and ultimately promotes microtubule disassembly. The tubulin curvature-sensing model is supported by our identification of Kip3 structural elements necessary and sufficient for plus-end binding and depolymerase activity, as well as by the identification of an α-tubulin residue specifically required for the Kip3-curved tubulin interaction. Together, these findings elucidate a major regulatory mechanism controlling the size of cellular microtubule structures. Kinesin-8 motors regulate the size of microtubule structures, using length-dependent accumulation at the plus end to preferentially disassemble long microtubules. Despite extensive study, the kinesin-8 depolymerase mechanism remains under debate. Here, we provide evidence for an alternative, tubulin curvature-sensing model of microtubule depolymerization by the budding yeast kinesin-8, Kip3. Kinesin-8/Kip3 uses ATP hydrolysis, like other kinesins, for stepping on the microtubule lattice, but at the plus end Kip3 undergoes a switch: its ATPase activity is suppressed when it binds tightly to the curved conformation of tubulin. This prolongs plus-end binding, stabilizes protofilament curvature, and ultimately promotes microtubule disassembly. The tubulin curvature-sensing model is supported by our identification of Kip3 structural elements necessary and sufficient for plus-end binding and depolymerase activity, as well as by the identification of an α-tubulin residue specifically required for the Kip3-curved tubulin interaction. Together, these findings elucidate a major regulatory mechanism controlling the size of cellular microtubule structures. •A tubulin binding switch enables length-dependent microtubule disassembly by Kip3•Tubulin binding suppresses Kip3 ATPase activity, promoting depolymerase activity•Loop11 sequence in Kip3 is necessary and sufficient for curved tubulin binding•Kip3 disassembly-resistant microtubules support the two-state binding switch model Kinesin-8s promote length-dependent microtubule disassembly. Arellano and colleagues define a mechanism for Kip3/kinesin-8 depolymerization that involves a tubulin curvature-sensing binding switch. They propose that high affinity curved tubulin binding, which is accompanied by suppressed ATPse activity, enables its depolymerase activity. This Kip3 binding switch is thus central to Kip3’s ability to selectively trim long microtubules, narrowing the length distribution of microtubules in cells. Kinesin-8 motors regulate the size of microtubule structures, using length-dependent accumulation at the plus end to preferentially disassemble long microtubules. Despite extensive study, the kinesin-8 depolymerase mechanism remains under debate. Here, we provide evidence for an alternative, tubulin curvature-sensing model of microtubule depolymerization by the budding yeast kinesin-8, Kip3. Kinesin-8/Kip3 uses ATP hydrolysis, like other kinesins, for stepping on the microtubule lattice, but at the plus end Kip3 undergoes a switch: its ATPase activity is suppressed when it binds tightly to the curved conformation of tubulin. This prolongs plus-end binding, stabilizes protofilament curvature, and ultimately promotes microtubule disassembly. The tubulin curvature-sensing model is supported by our identification of Kip3 structural elements necessary and sufficient for plus-end binding and depolymerase activity, as well as by the identification of an α-tubulin residue specifically required for the Kip3-curved tubulin interaction. Together, these findings elucidate a major regulatory mechanism controlling the size of cellular microtubule structures. |
Author | Su, Xiaolei Pellman, David Hancock, William Geyer, Elisabeth A. Arellano-Santoyo, Hugo Rice, Luke M. Chen, Geng-Yuan Stokasimov, Ema |
AuthorAffiliation | 6 University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA 94143 5 Penn State University, Department of Biomedical engineering, University Park, PA 16802 2 Dana Farber Cancer Institute, Department of Pediatric Oncology, Boston, MA 02215 3 Department of Cell Biology, Harvard Medical School, Boston, MA 02215 4 UT Southwestern, Department of Biophysics, Dallas TX 75390 1 Howard Hughes Medical Institute, Chevy Chase, MD 20815 |
AuthorAffiliation_xml | – name: 3 Department of Cell Biology, Harvard Medical School, Boston, MA 02215 – name: 4 UT Southwestern, Department of Biophysics, Dallas TX 75390 – name: 6 University of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA 94143 – name: 1 Howard Hughes Medical Institute, Chevy Chase, MD 20815 – name: 2 Dana Farber Cancer Institute, Department of Pediatric Oncology, Boston, MA 02215 – name: 5 Penn State University, Department of Biomedical engineering, University Park, PA 16802 |
Author_xml | – sequence: 1 givenname: Hugo surname: Arellano-Santoyo fullname: Arellano-Santoyo, Hugo organization: Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA – sequence: 2 givenname: Elisabeth A. surname: Geyer fullname: Geyer, Elisabeth A. organization: Department of Biophysics, UT Southwestern, Dallas, TX 75390, USA – sequence: 3 givenname: Ema surname: Stokasimov fullname: Stokasimov, Ema organization: Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA – sequence: 4 givenname: Geng-Yuan surname: Chen fullname: Chen, Geng-Yuan organization: Department of Biomedical Engineering, Penn State University, University Park, PA 16802, USA – sequence: 5 givenname: Xiaolei surname: Su fullname: Su, Xiaolei organization: Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143, USA – sequence: 6 givenname: William surname: Hancock fullname: Hancock, William organization: Department of Biomedical Engineering, Penn State University, University Park, PA 16802, USA – sequence: 7 givenname: Luke M. surname: Rice fullname: Rice, Luke M. organization: Department of Biophysics, UT Southwestern, Dallas, TX 75390, USA – sequence: 8 givenname: David surname: Pellman fullname: Pellman, David email: david_pellman@dfci.harvard.edu organization: Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA |
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Keywords | microtubule associated proteins spindle scaling depolymerization kinesins microtubule dynamics |
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SubjectTerms | Adenosine Triphosphate - metabolism Animals Biocatalysis depolymerization Hydrolysis Kinesin - chemistry Kinesin - metabolism kinesins microtubule associated proteins microtubule dynamics Microtubules - metabolism Models, Biological Models, Molecular Mutant Proteins - metabolism Polymerization Protein Binding Protein Structure, Secondary Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism spindle scaling Sus scrofa Tubulin - metabolism |
Title | A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity |
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