Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

• Published in: Blood Vol. 125; no. 7; pp. 1107 - 1115
• Main Authors: Kim, Yong Chan, Zhang, Ai-Hong, Su, Yan, Rieder, Sadiye Amcaoglu, Rossi, Robert J., Ettinger, Ruth A., Pratt, Kathleen P., Shevach, Ethan M., Scott, David W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.02.2015; American Society of Hematology
• Subjects: Adult; Aged; Animals; B-Lymphocytes, Regulatory - immunology; B-Lymphocytes, Regulatory - metabolism; Cell Engineering - methods; Cells, Cultured; Factor VIII - genetics; Factor VIII - immunology; Factor VIII - metabolism; Genetic Engineering; Genetic Therapy; Hemophilia A - genetics; Hemophilia A - immunology; Humans; Immune Tolerance - genetics; Immunobiology; Male; Mice; Middle Aged; T-Cell Antigen Receptor Specificity - genetics; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Young Adult

Expansion of human regulatory T cells (Tregs) for clinical applications offers great promise for the treatment of undesirable immune responses in autoimmunity, transplantation, allergy, and antidrug antibody responses, including inhibitor responses in hemophilia A patients. However, polyclonal Tregs...