Towards the development of multisensor for drugs of abuse based on molecular imprinted polymers

• Published in: Analytica chimica acta Vol. 542; no. 1; pp. 111 - 117
• Main Authors: Piletska, Elena V., Romero-Guerra, Maria, Chianella, Iva, Karim, Kal, Turner, Anthony P.F., Piletsky, Sergey A.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 22.06.2005; Elsevier
• Subjects: Analytical chemistry; Chemistry; Chromatographic methods and physical methods associated with chromatography; Cocaine; Deoxyephedrine; Exact sciences and technology; General, instrumentation; HPLC; Methadone; Molecular imprinting; Molecular modelling; Morphine; Other chromatographic methods; Sensor; TECHNOLOGY; TEKNIKVETENSKAP; Molecular modelling; Morphine; Cocaine; Methadone; Deoxyephedrine; Molecular imprinting; HPLC; Sensor; Performance evaluation; Automation; Multisensor; Stability; Molecular structure; HPLC chromatography; Polymer; Selectivity; Chemical sensor; Molecular complex; Robustness; Drug of abuse; Comparative study; cocaine; molecular imprinting; molecular modelling; sensor; deoxyephedrine; methadone; morphine

The synthetic receptors for cocaine, deoxyephedrine, methadone and morphine were computationally designed and produced using molecular imprinting. The structure and energy of the molecular complexes were analysed by computational techniques. The possible structures of the binding sites in the synthe...