Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

• Published in: Immunity (Cambridge, Mass.) Vol. 43; no. 1; pp. 15 - 28
• Main Authors: Lazear, Helen M., Nice, Timothy J., Diamond, Michael S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.07.2015
• Subjects: Adaptive Immunity - immunology; Animals; Antiviral Agents - immunology; Autoimmunity - immunology; Brain - immunology; Brain - virology; Gastrointestinal Tract - immunology; Gastrointestinal Tract - virology; Humans; Immunity, Innate - immunology; Interferon-gamma - immunology; Mice; Neoplasms - immunology; Signal Transduction - immunology; Virus Diseases - immunology

When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral IS...