HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

• Published in: Cellular physiology and biochemistry Vol. 47; no. 3; pp. 893 - 913
• Main Authors: Tang, Qing, Hann, Swei Sunny
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Apoptosis; Biomarkers; Bone cancer; Cancers; Cell cycle; Cell growth; Cell Movement; Cell Proliferation; Chromatin Assembly and Disassembly; Chromosomes; Epigenetics; Gene expression; HOTAIR; Humans; Leukemia; Long non-coding RNAs; Lung cancer; Metastasis; Neoplasm Metastasis; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Review; RNA Processing, Post-Transcriptional; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Neoplasm - genetics; RNA, Neoplasm - metabolism; Therapeutic targets; Transcription factors; Transcription, Genetic; HOTAIR; Biomarkers; Long non-coding RNAs; Cancers; Therapeutic targets

Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated...