Report and Recommendations of the Workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity

• Published in: Cardiovascular toxicology Vol. 9; no. 3; pp. 107 - 125
• Main Authors: Stummann, Tina C, Beilmann, Mario, Duker, Göran, Dumotier, Berengere, Fredriksson, J. Magnus, Jones, Robin L, Hasiwa, Marina, Kang, Y. James, Mandenius, Carl-Fredrik, Meyer, Thomas, Minotti, Giorgio, Valentin, Y. Jean-Pierre, Zünkler, Bernd J, Bremer, Susanne
• Format: Journal Article
• Language: English
• Published: New York New York : Humana Press Inc 01.09.2009; Humana Press Inc; Springer Nature B.V
• Subjects: Alternative tests; Animal Testing Alternatives - methods; Animal Testing Alternatives - trends; Animals; Animals, Laboratory; Arrhythmias; Arrhythmias, Cardiac - chemically induced; Arrhythmias, Cardiac - prevention & control; Biomedical and Life Sciences; Biomedicine; Cardiology; Cardiotoxicity; Cardiotoxins - adverse effects; Cardiotoxins - toxicity; Clinical trials; Contractility toxicity; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions - chemically induced; Drug-Related Side Effects and Adverse Reactions - prevention & control; Drugs; Education - trends; Europe; Health Planning Guidelines; Humans; Ischaemia toxicity; MEDICIN; MEDICINE; Pharmacology/Toxicology; Secondary cardiotoxicity; Valve toxicity; Europe; Drugs; Valve toxicity; Secondary cardiotoxicity; Cardiotoxicity; Ischaemia toxicity; Alternative tests; Arrhythmias; Contractility toxicity

Cardiotoxicity is among the leading reasons for drug attrition and is therefore a core subject in non-clinical and clinical safety testing of new drugs. European Centre for the Validation of Alternative Methods held in March 2008 a workshop on “Alternative Methods for Drug-induced Cardiotoxicity” in...