Impact of age on exercise-induced ATP supply during supramaximal plantar flexion in humans

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 309; no. 4; pp. R378 - R388
• Main Authors: Layec, Gwenael, Trinity, Joel D., Hart, Corey R., Kim, Seong-Eun, Groot, H. Jonathan, Fur, Yann Le, Sorensen, Jacob R., Jeong, Eun-Kee, Richardson, Russell S.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.08.2015
• Subjects: Adenosine triphosphatase; Adenosine Triphosphate - metabolism; Age; Age Factors; Aged; Aged, 80 and over; Aging - metabolism; ATP; Biosynthesis; Creatine Kinase, MM Form - metabolism; Energy Metabolism; Exercise; Female; Glycolysis; Humans; Magnetic Resonance Spectroscopy; Male; Metabolism; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal - metabolism; Obesity, Diabetes and Energy Homeostasis; Older people; Oxidative Phosphorylation; Physical Activity and Inactivity; Physiology; Time Factors; Young Adult; adenosine triphosphate synthesis pathways; phosphorus-31 magnetic resonance spectroscopy; glycolysis

Currently, the physiological factors responsible for exercise intolerance and bioenergetic alterations with age are poorly understood due, at least in art, to the confounding effect of reduced physical activity in the elderly. Thus, in 40 healthy young (22 ± 2 yr) and old (74 ± 8 yr) activity-matche...