Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury

• Published in: The American journal of pathology Vol. 189; no. 6; pp. 1241 - 1255
• Main Authors: Wilkinson, Patrick D., Alencastro, Frances, Delgado, Evan R., Leek, Madeleine P., Weirich, Matthew P., Otero, P. Anthony, Roy, Nairita, Brown, Whitney K., Oertel, Michael, Duncan, Andrew W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2019; American Society for Investigative Pathology
• Subjects: Adaptation, Physiological; Animals; E2F7 Transcription Factor - deficiency; Gene Knockdown Techniques; Hepatocytes - metabolism; Hepatocytes - pathology; Liver Regeneration; Lung Injury - genetics; Lung Injury - metabolism; Lung Injury - pathology; Mice; Mice, Inbred NOD; Mice, Knockout; Polyploidy; Repressor Proteins - deficiency

The liver contains diploid and polyploid hepatocytes (tetraploid, octaploid, etc.), with polyploids comprising ≥90% of the hepatocyte population in adult mice. Polyploid hepatocytes form multipolar spindles in mitosis, which lead to chromosome gains/losses and random aneuploidy. The effect of aneupl...