Transmissibility of Hepatitis B Virus (HBV) Infection through Blood Transfusion from Blood Donors with Occult HBV Infection

• Published in: Clinical infectious diseases Vol. 52; no. 5; pp. 624 - 632
• Main Authors: Yuen, Man-Fung, Wong, Danny Ka-Ho, Lee, Cheuk-Kwong, Tanaka, Yasuhito, Allain, Jean-Pierre, Fung, James, Leung, Jennifer, Lin, Che-Kit, Sugiyama, Masaya, Sugauchi, Fuminaka, Mizokami, Masashi, Lai, Ching-Lung
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2011
• Subjects: Adolescent; Adult; Animals; ARTICLES AND COMMENTARIES; Bacterial diseases; Bacterial sepsis; Biological and medical sciences; Blood; Blood & organ donations; Blood - virology; Blood donation; Blood Donors; Blood transfusion; Blood transfusions; Deoxyribonucleic acid; Disease Models, Animal; Disease transmission; DNA; DNA, Viral - genetics; DNA, Viral - isolation & purification; Female; Genotypes; Hepatitis; Hepatitis antigens; Hepatitis B; Hepatitis B - transmission; Hepatitis B virus; Hepatitis B virus - classification; Hepatitis B virus - genetics; Hepatitis B virus - isolation & purification; Human bacterial diseases; Human viral diseases; Humans; Infections; Infectious diseases; Liver; Liver - virology; Male; Medical sciences; Mice; Middle Aged; Phylogenetics; Phylogeny; Risk Assessment; Risk factors; Rodents; Sequence Analysis, DNA; Transfusion Reaction; Viral diseases; Viral hepatitis; Young Adult; Transfusion; Orthohepadnavirus; Hepatic disease; Bacteremia; Infection; Virus; Viral hepatitis B; Hepadnaviridae; Viral disease; Bacteriosis; Digestive diseases; Hepatitis B virus; Blood donor
• ISSN: 1058-4838; 1537-6591; 1537-6591
• DOI: 10.1093/cid/ciq247

Background. Studies of the transmissibility of hepatitis B virus (HBV) in occult hepatitis B (OHB) through blood transfusion are scarce. We aimed to determine the transmissibility of HBV in blood donors with OHB through transfusion in animal and human studies. Methods. Among 217,595 blood donors, 67...