Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 311; no. 1; pp. L124 - L134
• Main Authors: Nozik-Grayck, Eva, Woods, Crystal, Stearman, Robert S., Venkataraman, Sujatha, Ferguson, Bradley S., Swain, Kalin, Bowler, Russell P., Geraci, Mark W., Ihida-Stansbury, Kaori, Stenmark, Kurt R., McKinsey, Timothy A., Domann, Frederick E.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2016
• Subjects: Acetylation; Adult; Animal models; Animals; Cells, Cultured; Deoxyribonucleic acid; DNA; DNA methylation; Enzyme Repression; Enzymes; Female; Gene Expression; Histone Deacetylase Inhibitors - pharmacology; Histones - metabolism; Humans; Hypertension; Hypertension, Pulmonary - enzymology; Male; Middle Aged; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - enzymology; Promoter Regions, Genetic; Protein expression; Protein Processing, Post-Translational; Pulmonary hypertension; Rats; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Young Adult; DNA methylation; histone deacetylation; extracellular superoxide dismutase; idiopathic pulmonary arterial hypertension

Epigenetic mechanisms, including DNA methylation and histone acetylation, regulate gene expression in idiopathic pulmonary arterial hypertension (IPAH). These mechanisms can modulate expression of extracellular superoxide dismutase (SOD3 or EC-SOD), a key vascular antioxidant enzyme, and loss of vas...