Characterization of Plasmodium berghei Homologues of T-cell Immunomodulatory Protein as a New Potential Candidate for Protecting against Experimental Cerebral Malaria

• Published in: Korean journal of parasitology Vol. 57; no. 2; pp. 101 - 115
• Main Authors: Cui, Ai, Li, Yucen, Zhou, Xia, Wang, Lin, Luo, Enjie
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한기생충학열대의학회 01.04.2019; The Korean Society for Parasitology and Tropical Medicine
• Subjects: Administration, Intravenous; Animals; Brain - pathology; Disease Models, Animal; Endothelial Cells - drug effects; Immunologic Factors - administration & dosage; Immunologic Factors - isolation & purification; Lymphocyte Activation; Malaria, Cerebral - pathology; Malaria, Cerebral - prevention & control; Membrane Proteins - administration & dosage; Membrane Proteins - genetics; Membrane Proteins - isolation & purification; Mice, Inbred BALB C; Mice, Inbred C57BL; Original; Plasmodium berghei - genetics; Plasmodium berghei - immunology; Protozoan Proteins - administration & dosage; Protozoan Proteins - genetics; Protozoan Proteins - isolation & purification; Recombinant Proteins - administration & dosage; Recombinant Proteins - genetics; Recombinant Proteins - isolation & purification; T-Lymphocytes, Regulatory - drug effects; Treatment Outcome; T-cell immunomodulatory protein; Plasmodium berghei; inflammatory cytokine; experimental; immunopathology; cerebral malaria

The pathogenesis of cerebral malaria is biologically complex and involves multi-factorial mechanisms such as microvascular congestion, immunopathology by the pro-inflammatory cytokine and endothelial dysfunction. Recent data have suggested that a pleiotropic T-cell immunomodulatory protein (TIP) cou...