Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control

• Published in: Genes & nutrition Vol. 17; no. 1; p. 1
• Main Authors: Chan, Yap-Hang, Schooling, C. Mary, Zhao, Jie V., Yeung, Shiu-Lun Au, Hai, Jo Jo, Thomas, G. Neil, Cheng, Kar-Keung, Jiang, Chao-Qiang, Wong, Yuen-Kwun, Au, Ka-Wing, Tang, Clara S., Cheung, Chloe Y. Y., Xu, Aimin, Sham, Pak-Chung, Lam, Tai-Hing, Lam, Karen Siu-Ling, Tse, Hung-Fat
• Format: Journal Article
• Language: English
• Published: Germany BioMed Central 29.01.2022
• Subjects: 25-Hydroxyvitamin D; Angina; Blood pressure; blood serum; Cardiovascular diseases; Cerebral infarction; Cholesterol; Congestive heart failure; Creatinine; death; Diabetes; Diabetes mellitus (non-insulin dependent); Enzymes; Genomes; Glucose; Health risk assessment; heart failure; High density lipoprotein; Hypertension; Hypotheses; Ischemia; Myocardial infarction; noninsulin-dependent diabetes mellitus; risk; Single-nucleotide polymorphism; stroke; Triglycerides; Vascular diseases; Vitamin D; United States > US; Hypertension; Type 2 diabetes; Vitamin D; Secondary prevention; Chinese; Mendelian randomization; Exome Chip
• ISSN: 1555-8932; 1865-3499
• DOI: 10.1186/s12263-022-00704-z

Vitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and hypertension. Whether genetially predicted vitamin D status (serological 25-hydroxyvitamin D [25(OH)D]) confers secondary protection against cardiovascular diseas...