Differential induction of plasma cells by isoforms of human TACI

• Published in: Blood Vol. 125; no. 11; pp. 1749 - 1758
• Main Authors: Garcia-Carmona, Yolanda, Cols, Montserrat, Ting, Adrian T., Radigan, Lin, Yuk, Frank J., Zhang, Li, Cerutti, Andrea, Cunningham-Rundles, Charlotte
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.03.2015; American Society of Hematology
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Alternative Splicing; Animals; B-Lymphocyte Subsets - cytology; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; Cell Differentiation; Common Variable Immunodeficiency - genetics; Common Variable Immunodeficiency - immunology; Common Variable Immunodeficiency - metabolism; DNA-Binding Proteins - genetics; Humans; Immunobiology; Mice; Mutagenesis, Site-Directed; Myeloid Differentiation Factor 88 - metabolism; Plasma Cells - cytology; Plasma Cells - immunology; Plasma Cells - metabolism; Positive Regulatory Domain I-Binding Factor 1; Precursor Cells, B-Lymphoid - cytology; Precursor Cells, B-Lymphoid - immunology; Precursor Cells, B-Lymphoid - metabolism; Protein Isoforms - genetics; Protein Isoforms - immunology; Protein Isoforms - metabolism; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Recombinant Proteins - metabolism; Regulatory Factor X Transcription Factors; Repressor Proteins - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction; Transcription Factor RelA - metabolism; Transcription Factors - genetics; Transduction, Genetic; Transmembrane Activator and CAML Interactor Protein - genetics; Transmembrane Activator and CAML Interactor Protein - immunology; Transmembrane Activator and CAML Interactor Protein - metabolism; X-Box Binding Protein 1

Subjects with common variable immune deficiency may have mutations in transmembrane activator calcium modulator and cyclophilin ligand interactor (TACI). Unlike the murine gene, human TACI undergoes alternative messenger (m)RNA splicing to produce isoforms with 1 or 2 ligand-binding domains. Because...