Nonclinical safety evaluation of sunitinib: a potent inhibitor of VEGF, PDGF, KIT, FLT3, and RET receptors - Patyna, Shem; Arrigoni, Claudio; Terron, Andrea; Kim, Tae-Won; Heward, Joyce K; Vonderfecht, Steven L; Denlinger, Robert; Turnquist, Susan E; Evering, Winston (Toxicologic pathology, 2008)
Keywords: Adrenal Glands - drug effects; Adrenal Glands - pathology; Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - toxicity; Bone Marrow - drug effects; Bone Marrow - pathology; Female; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - pathology; Growth Plate - drug effects; Growth Plate - pathology; Incisor - drug effects; Incisor - pathology; Indoles - administration & dosage; Indoles - pharmacokinetics; Indoles - toxicity; Lymphoid Tissue - drug effects; Lymphoid Tissue - pathology; Macaca fascicularis; Male; Microscopy, Electron; Neovascularization, Pathologic - chemically induced; Neovascularization, Pathologic - pathology; Ovary - drug effects; Ovary - pathology; Pancreas - drug effects; Pancreas - pathology; Pyrroles - administration & dosage; Pyrroles - pharmacokinetics; Pyrroles - toxicity; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases - antagonists & inhibitors; Recovery of Function - drug effects; Signal Transduction - drug effects; Toxicity Tests, Chronic - methods