Full-mouth Tooth Extraction Lowers Systemic Inflammatory and Thrombotic Markers of Cardiovascular Risk

Prior studies of a link between periodontal and cardiovascular disease have been limited by being predominantly observational. We used a treatment intervention model to study the relationship between periodontitis and systemic inflammatory and thrombotic cardiovascular indicators of risk. We studied...

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Published inJournal of dental research Vol. 85; no. 1; pp. 74 - 78
Main Authors Taylor, B.A., Tofler, G.H., Carey, H.M.R., Morel-Kopp, M.-C., Philcox, S., Carter, T.R., Elliott, M.J., Kull, A.D., Ward, C., Schenck, K.
Format Journal Article
LanguageEnglish
Published United States SAGE Publications 01.01.2006
SAGE PUBLICATIONS, INC
Subjects
Adult
C-Reactive Protein - analysis
Cohort Studies
Dentistry
Diabetes Mellitus - blood
Female
Fibrinogen - analysis
Follow-Up Studies
Heart Diseases - blood
Humans
Hyperlipidemias - blood
Hypertension - blood
Inflammation Mediators - blood
Leukocyte Count
Longitudinal Studies
Male
Middle Aged
Periodontitis - therapy
Plasminogen Activator Inhibitor 1 - blood
Platelet Count
Risk Factors
Smoking - blood
Thrombosis - blood
Tissue Plasminogen Activator - blood
Tooth Extraction
cardiovascular disease
periodontal disease
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Summary:Prior studies of a link between periodontal and cardiovascular disease have been limited by being predominantly observational. We used a treatment intervention model to study the relationship between periodontitis and systemic inflammatory and thrombotic cardiovascular indicators of risk. We studied 67 adults with advanced periodontitis requiring full-mouth tooth extraction. Blood samples were obtained: (1) at initial presentation, immediately prior to treatment of presenting symptoms; (2) one to two weeks later, before all teeth were removed; and (3) 12 weeks after full-mouth tooth extraction. After full-mouth tooth extraction, there was a significant decrease in C-reactive protein, plasminogen activator inhibitor-1 and fibrinogen, and white cell and platelet counts. This study shows that elimination of advanced periodontitis by full-mouth tooth extraction reduces systemic inflammatory and thrombotic markers of cardiovascular risk. Analysis of the data supports the hypothesis that treatment of periodontal disease may lower cardiovascular risk, and provides a rationale for further randomized studies.
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ISSN:0022-0345
1544-0591
DOI:10.1177/154405910608500113