Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

• Published in: Drug delivery Vol. 18; no. 2; pp. 97 - 110
• Main Authors: Pawar, Vivek K., Kansal, Shaswat, Garg, Garima, Awasthi, Rajendra, Singodia, Deepak, Kulkarni, Giriraj T.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.02.2011; Taylor & Francis
• Subjects: Administration, Oral; Animals; Chemistry, Pharmaceutical - methods; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacokinetics; dual working systems; expandable systems; floating drug delivery systems; Gastric Emptying - physiology; Gastroretentive drug delivery systems; Humans; magnetic systems; mucoadhesive systems; Stomach - metabolism; superporous systems

In the present era, gastroretentive dosage forms (GRDF) receive great attention because they can improve the performance of controlled release systems. An optimum GRDF system can be defined as a system which retains in the stomach for a sufficient time interval against all the physiological barriers...