Histologic Evaluation of Biopsy Specimens Obtained After Rotator Cuff Repair Augmented With a Highly Porous Collagen Implant
Purpose To histologically evaluate biopsy specimens from patients who previously underwent rotator cuff repair augmented with a highly porous collagen implant. Methods Biopsies of collagen implant/host-tissue constructs were obtained from 7 patients undergoing a second arthroscopic procedure at vari...
Saved in:
Published in | Arthroscopy Vol. 33; no. 2; pp. 278 - 283 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.02.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Purpose To histologically evaluate biopsy specimens from patients who previously underwent rotator cuff repair augmented with a highly porous collagen implant. Methods Biopsies of collagen implant/host-tissue constructs were obtained from 7 patients undergoing a second arthroscopic procedure at various time periods (5 weeks to 6 months) after arthroscopic rotator cuff repair augmented with a collagen implant overlay. The biopsy specimens were examined histologically for host-tissue ingrowth, host-tissue maturation, and host-implant biocompatibility. Results At the earliest time period (5 weeks), the biopsy revealed the presence of host cells (fibroblasts) within the interstices of the porous collagen implant. Cells were aligned along the linear orientation of the collagen implant structure, and there was evidence of early collagen formation. The 3-month biopsies showed increased collagen formation, maturation, and organization over the surface of the implant and evidence of the collagen implant. At 6 months, the newly generated tissue had the histologic appearance of a tendon, suggesting functional loading of the new generated host tissue. There was no evidence of any remnants of the collagen implant in the 6-month biopsy. There was no evidence of any inflammatory or foreign body reaction within any of the tissue samples. Conclusions Biopsies of collagen implants retrieved from human rotator cuff repair subjects revealed cellular incorporation, tissue formation and maturation, implant resorption, and biocompatibility. Clinical Relevance The histologic observations from these clinical biopsies support the biocompatibility of this implant and its ability to promote new connective tissue with the histological appearance of tendon over the surface of the native cuff tendon. |
---|---|
AbstractList | To histologically evaluate biopsy specimens from patients who previously underwent rotator cuff repair augmented with a highly porous collagen implant.
Biopsies of collagen implant/host-tissue constructs were obtained from 7 patients undergoing a second arthroscopic procedure at various time periods (5 weeks to 6 months) after arthroscopic rotator cuff repair augmented with a collagen implant overlay. The biopsy specimens were examined histologically for host-tissue ingrowth, host-tissue maturation, and host-implant biocompatibility.
At the earliest time period (5 weeks), the biopsy revealed the presence of host cells (fibroblasts) within the interstices of the porous collagen implant. Cells were aligned along the linear orientation of the collagen implant structure, and there was evidence of early collagen formation. The 3-month biopsies showed increased collagen formation, maturation, and organization over the surface of the implant and evidence of the collagen implant. At 6 months, the newly generated tissue had the histologic appearance of a tendon, suggesting functional loading of the new generated host tissue. There was no evidence of any remnants of the collagen implant in the 6-month biopsy. There was no evidence of any inflammatory or foreign body reaction within any of the tissue samples.
Biopsies of collagen implants retrieved from human rotator cuff repair subjects revealed cellular incorporation, tissue formation and maturation, implant resorption, and biocompatibility.
The histologic observations from these clinical biopsies support the biocompatibility of this implant and its ability to promote new connective tissue with the histological appearance of tendon over the surface of the native cuff tendon. Purpose To histologically evaluate biopsy specimens from patients who previously underwent rotator cuff repair augmented with a highly porous collagen implant. Methods Biopsies of collagen implant/host-tissue constructs were obtained from 7 patients undergoing a second arthroscopic procedure at various time periods (5 weeks to 6 months) after arthroscopic rotator cuff repair augmented with a collagen implant overlay. The biopsy specimens were examined histologically for host-tissue ingrowth, host-tissue maturation, and host-implant biocompatibility. Results At the earliest time period (5 weeks), the biopsy revealed the presence of host cells (fibroblasts) within the interstices of the porous collagen implant. Cells were aligned along the linear orientation of the collagen implant structure, and there was evidence of early collagen formation. The 3-month biopsies showed increased collagen formation, maturation, and organization over the surface of the implant and evidence of the collagen implant. At 6 months, the newly generated tissue had the histologic appearance of a tendon, suggesting functional loading of the new generated host tissue. There was no evidence of any remnants of the collagen implant in the 6-month biopsy. There was no evidence of any inflammatory or foreign body reaction within any of the tissue samples. Conclusions Biopsies of collagen implants retrieved from human rotator cuff repair subjects revealed cellular incorporation, tissue formation and maturation, implant resorption, and biocompatibility. Clinical Relevance The histologic observations from these clinical biopsies support the biocompatibility of this implant and its ability to promote new connective tissue with the histological appearance of tendon over the surface of the native cuff tendon. PURPOSETo histologically evaluate biopsy specimens from patients who previously underwent rotator cuff repair augmented with a highly porous collagen implant.METHODSBiopsies of collagen implant/host-tissue constructs were obtained from 7 patients undergoing a second arthroscopic procedure at various time periods (5 weeks to 6 months) after arthroscopic rotator cuff repair augmented with a collagen implant overlay. The biopsy specimens were examined histologically for host-tissue ingrowth, host-tissue maturation, and host-implant biocompatibility.RESULTSAt the earliest time period (5 weeks), the biopsy revealed the presence of host cells (fibroblasts) within the interstices of the porous collagen implant. Cells were aligned along the linear orientation of the collagen implant structure, and there was evidence of early collagen formation. The 3-month biopsies showed increased collagen formation, maturation, and organization over the surface of the implant and evidence of the collagen implant. At 6 months, the newly generated tissue had the histologic appearance of a tendon, suggesting functional loading of the new generated host tissue. There was no evidence of any remnants of the collagen implant in the 6-month biopsy. There was no evidence of any inflammatory or foreign body reaction within any of the tissue samples.CONCLUSIONSBiopsies of collagen implants retrieved from human rotator cuff repair subjects revealed cellular incorporation, tissue formation and maturation, implant resorption, and biocompatibility.CLINICAL RELEVANCEThe histologic observations from these clinical biopsies support the biocompatibility of this implant and its ability to promote new connective tissue with the histological appearance of tendon over the surface of the native cuff tendon. |
Author | Hommen, Jan Pieter, M.D Van Kampen, Craig, Ph.D Bushnell, Brad D., M.D., M.B.A Schofield, Brian, M.D Arnoczky, Steven P., D.V.M Bishai, Shariff K., D.O., M.S., F.A.O.A.O Sigman, Scott, M.D |
Author_xml | – sequence: 1 fullname: Arnoczky, Steven P., D.V.M – sequence: 2 fullname: Bishai, Shariff K., D.O., M.S., F.A.O.A.O – sequence: 3 fullname: Schofield, Brian, M.D – sequence: 4 fullname: Sigman, Scott, M.D – sequence: 5 fullname: Bushnell, Brad D., M.D., M.B.A – sequence: 6 fullname: Hommen, Jan Pieter, M.D – sequence: 7 fullname: Van Kampen, Craig, Ph.D |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27650821$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkVtrFDEUgINU7Lb6D0Ty6Mtsc5mZZF6EdaluoVBpFX0L2ezJbtaZZEwyhQV_fLNs9cEX4UAIfOf2nQt05oMHhN5SMqeEtlf7uY55F8Ocld-clKjFCzSjDWsrzjg9QzMi6q6SpOXn6CKlPSGEc8lfoXMm2oZIRmfo98qlHPqwdQZfP-p-0tkFj4PFH10Y0wE_jGDcAD7hu3XWzsMGL2yGiO9D1jlEvJysxfcwahfxYtoWNBfmu8s7rPHKbXf9AX8JMUwJL0Pf6y14fDOMvfb5NXppdZ_gzfN7ib59uv66XFW3d59vlovbytQtz5WxjHZCc0utsFJz0umu7mjTGckltcy2ogNCmlZo0lqQULZnICVla9pIMPwSvT_VHWP4NUHKanDJQBnGQ5lLUdl0gotOdAWtT6iJIaUIVo3RDToeFCXq6F3t1cm7OnpXpEQtStq75w7TeoDN36Q_ogvw4QRA2fPRQVTJOPAGNi6CyWoT3P86_FvA9M47o_ufcIC0D1P0xaGiKjFF1MPx9sfT05aTuml_8Cd-xa0w |
CitedBy_id | crossref_primary_10_4055_jkoa_2021_56_6_472 crossref_primary_10_1016_j_jse_2018_11_044 crossref_primary_10_1016_j_jse_2017_08_023 crossref_primary_10_1177_23259671211050899 crossref_primary_10_1155_2022_8788061 crossref_primary_10_1177_23259671211027850 crossref_primary_10_1016_j_arthro_2022_06_004 crossref_primary_10_1016_j_arthro_2024_02_001 crossref_primary_10_1016_j_eats_2022_08_051 crossref_primary_10_3390_bioengineering8010008 crossref_primary_10_1016_j_arthro_2023_12_014 crossref_primary_10_1016_j_arthro_2023_10_024 crossref_primary_10_1016_j_jse_2018_11_067 crossref_primary_10_1016_j_asmr_2021_07_009 crossref_primary_10_1016_j_jseint_2020_10_020 crossref_primary_10_1016_j_jse_2023_03_031 crossref_primary_10_1177_03635465211053334 crossref_primary_10_2106_JBJS_CC_22_00383 crossref_primary_10_1016_j_ocl_2018_08_005 crossref_primary_10_1016_j_eats_2021_08_007 crossref_primary_10_1136_bcr_2023_255469 crossref_primary_10_1177_03635465211049434 crossref_primary_10_1016_j_arthro_2019_02_019 crossref_primary_10_1002_ksa_12326 crossref_primary_10_1016_j_eats_2023_07_061 crossref_primary_10_1016_j_jse_2020_10_022 crossref_primary_10_1093_rb_rbac062 crossref_primary_10_1016_j_jse_2022_05_025 crossref_primary_10_1016_j_xrrt_2021_06_004 crossref_primary_10_1177_0363546519850795 crossref_primary_10_1007_s12178_018_9469_0 crossref_primary_10_1016_j_otsr_2020_03_022 crossref_primary_10_1016_j_eats_2024_102993 crossref_primary_10_1097_JSA_0000000000000395 crossref_primary_10_1016_j_eats_2020_03_027 crossref_primary_10_1016_j_xrrt_2022_02_008 crossref_primary_10_1089_ten_teb_2023_0320 crossref_primary_10_1186_s40634_022_00495_7 |
Cites_doi | 10.32098/mltj.01.2016.03 10.1098/rsif.2008.0151 10.1177/03635465010290021001 10.1016/j.arthro.2008.05.023 10.1902/jop.1976.47.7.380 10.1002/jbm.820110113 10.1016/j.ejphar.2015.03.048 10.32098/mltj.03.2013.17 10.32098/mltj.03.2015.01 10.1038/nrm3896 10.1053/j.jfas.2009.10.003 10.1302/0301-620X.65B3.6841400 10.1177/0363546505279912 |
ContentType | Journal Article |
Copyright | Arthroscopy Association of North America 2016 Arthroscopy Association of North America Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: Arthroscopy Association of North America – notice: 2016 Arthroscopy Association of North America – notice: Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.arthro.2016.06.047 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1526-3231 |
EndPage | 283 |
ExternalDocumentID | 10_1016_j_arthro_2016_06_047 27650821 S074980631630456X 1_s2_0_S074980631630456X |
Genre | Journal Article |
GroupedDBID | --K .1- .FO .GJ 0R~ 1B1 1P~ 1RT 1~5 3O- 4.4 457 4G. 53G 5RE 5VS 7-5 AAEDT AAEDW AALRI AAQFI AAQQT AAQXK AAXUO ABLJU ABMAC ADBBV ADMUD ADPAM AEVXI AFCTW AFJKZ AFRHN AFTJW AHHHB AITUG AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BELOY C5W CAG COF EBS EFJIC EJD F5P FDB FEDTE FGOYB G-2 GBLVA HEE HEK HMK HMO HVGLF HZ~ IHE J1W KOM M28 M31 M41 MO0 N9A NQ- O9- OF~ OR- R2- RIG ROL RPZ SAE SEL SES SEW SJN SSZ UHS UV1 WUQ XH2 YCJ Z5R ZXP AAIAV AGZHU ALXNB ZA5 CGR CUY CVF ECM EIF NPM AAYXX ACRPL ADNMO CITATION 7X8 |
ID | FETCH-LOGICAL-c463t-cf2197a3f1f7f8a309a949159c8381f2f679e00567a06fe8e2312e8812b158ec3 |
ISSN | 0749-8063 |
IngestDate | Fri Aug 16 23:27:53 EDT 2024 Fri Dec 06 02:56:42 EST 2024 Sat Sep 28 08:10:01 EDT 2024 Fri Feb 23 02:25:28 EST 2024 Tue Oct 15 22:57:00 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Language | English |
License | Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c463t-cf2197a3f1f7f8a309a949159c8381f2f679e00567a06fe8e2312e8812b158ec3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | http://www.arthroscopyjournal.org/article/S074980631630456X/pdf |
PMID | 27650821 |
PQID | 1859737979 |
PQPubID | 23479 |
PageCount | 6 |
ParticipantIDs | proquest_miscellaneous_1859737979 crossref_primary_10_1016_j_arthro_2016_06_047 pubmed_primary_27650821 elsevier_sciencedirect_doi_10_1016_j_arthro_2016_06_047 elsevier_clinicalkeyesjournals_1_s2_0_S074980631630456X |
PublicationCentury | 2000 |
PublicationDate | 2017-02-01 |
PublicationDateYYYYMMDD | 2017-02-01 |
PublicationDate_xml | – month: 02 year: 2017 text: 2017-02-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Arthroscopy |
PublicationTitleAlternate | Arthroscopy |
PublicationYear | 2017 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Arnoczky, Wilson (bib12) 1986 DeCarbo, Feldner, Hyer (bib20) 2010; 49 Bokor, Sonnabend, Deady (bib2) 2015; 5 Garant (bib7) 1976; 47 Phipatanakul, Petersen (bib18) 2009; 38 Dahhan, Benazet, Rey, Leandri (bib16) 1981; 118 Snyder, Arnoczky, Bond, Dopirak (bib5) 2009; 25 Schlegel, Hawkins, Lewis, Motta, Turner (bib15) 2006; 34 Navarro, Michiardi, Castano, Planell (bib4) 2008; 5 Walton, Bowman, Khatib, Linklater, Murrell (bib17) 2007; 89 Bokor, Sonnabend, Deady (bib3) 2016; 6 Arnoczky (bib13) 1990 Ross, Pawlina (bib10) 2006 Huang, Yannas (bib8) 1977; 8 Via, De Cupis, Spoliti, Oliva (bib6) 2013; 3 Cavagnaro, Silva Lima (bib11) 2015; 759 Van Kampen, Arnoczky, Parks (bib1) 2013; 3 Dejardin, Arnoczky, Ewers, Haut, Clarke (bib14) 2001; 29 Humphrey, Dufresne, Schwartz (bib9) 2014; 15 Rushton, Dandy, Naylor (bib19) 1983; 65 Walton (10.1016/j.arthro.2016.06.047_bib17) 2007; 89 Arnoczky (10.1016/j.arthro.2016.06.047_bib13) 1990 Bokor (10.1016/j.arthro.2016.06.047_bib3) 2016; 6 Via (10.1016/j.arthro.2016.06.047_bib6) 2013; 3 Cavagnaro (10.1016/j.arthro.2016.06.047_bib11) 2015; 759 Navarro (10.1016/j.arthro.2016.06.047_bib4) 2008; 5 Dejardin (10.1016/j.arthro.2016.06.047_bib14) 2001; 29 Ross (10.1016/j.arthro.2016.06.047_bib10) 2006 Snyder (10.1016/j.arthro.2016.06.047_bib5) 2009; 25 Rushton (10.1016/j.arthro.2016.06.047_bib19) 1983; 65 DeCarbo (10.1016/j.arthro.2016.06.047_bib20) 2010; 49 Garant (10.1016/j.arthro.2016.06.047_bib7) 1976; 47 Huang (10.1016/j.arthro.2016.06.047_bib8) 1977; 8 Schlegel (10.1016/j.arthro.2016.06.047_bib15) 2006; 34 Arnoczky (10.1016/j.arthro.2016.06.047_bib12) 1986 Humphrey (10.1016/j.arthro.2016.06.047_bib9) 2014; 15 Dahhan (10.1016/j.arthro.2016.06.047_bib16) 1981; 118 Phipatanakul (10.1016/j.arthro.2016.06.047_bib18) 2009; 38 Bokor (10.1016/j.arthro.2016.06.047_bib2) 2015; 5 Van Kampen (10.1016/j.arthro.2016.06.047_bib1) 2013; 3 |
References_xml | – volume: 25 start-page: 329 year: 2009 end-page: 333 ident: bib5 article-title: Histological evaluation of a biopsy specimen obtained 3-month after rotator cuff augmentation with GraftJacket Matrix publication-title: Arthroscopy contributor: fullname: Dopirak – start-page: 401 year: 1990 end-page: 417 ident: bib13 article-title: Animal models for knee ligament research publication-title: The knee ligaments: structure, function, injury, and repair contributor: fullname: Arnoczky – volume: 15 start-page: 802 year: 2014 end-page: 812 ident: bib9 article-title: Mechanotransduction and extracellular matrix homeostasis publication-title: Nat Rev Mol Cell Biol contributor: fullname: Schwartz – volume: 6 start-page: 16 year: 2016 end-page: 25 ident: bib3 article-title: Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up publication-title: Muscles Ligaments Tendons J contributor: fullname: Deady – start-page: 67 year: 1986 end-page: 108 ident: bib12 article-title: Experimental surgery of the skeletal system publication-title: Methods of animal experimentation. Vol. VII. Research surgery and care of the research animal. Part B: Surgical approaches to the organ systems contributor: fullname: Wilson – volume: 29 start-page: 175 year: 2001 end-page: 184 ident: bib14 article-title: Tissue-engineered rotator cuff tendon using porcine small intestine submucosa. Histologic and mechanical evaluation in dogs publication-title: Am J Sports Med contributor: fullname: Clarke – volume: 118 start-page: 275 year: 1981 end-page: 280 ident: bib16 article-title: Use of carbon fibers to repair the anterior cruciate ligament of the knee publication-title: J Chir contributor: fullname: Leandri – volume: 5 start-page: 144 year: 2015 end-page: 150 ident: bib2 article-title: Preliminary investigation of a biological augmentation of rotator cuff repairs using a collagen implant: a 2-year MRI follow-up publication-title: Muscles Ligaments Tendons J contributor: fullname: Deady – volume: 34 start-page: 275 year: 2006 end-page: 280 ident: bib15 article-title: The effects of augmentation with swine small intestine submucosa on tendon healing under tension: histologic and mechanical evaluations in sheep publication-title: Am J Sports Med contributor: fullname: Turner – volume: 5 start-page: 1137 year: 2008 end-page: 1158 ident: bib4 article-title: Biomaterials in orthopaedics publication-title: J R Soc Interface contributor: fullname: Planell – volume: 3 start-page: 229 year: 2013 end-page: 235 ident: bib1 article-title: Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: a histological evaluation in sheep publication-title: Muscles Ligaments Tendons J contributor: fullname: Parks – volume: 89 start-page: 786 year: 2007 end-page: 791 ident: bib17 article-title: Restore orthobiologoic implant: not recommended for augmentation of rotator cuff repairs publication-title: J Bone Joint Surg Am contributor: fullname: Murrell – volume: 3 start-page: 70 year: 2013 end-page: 79 ident: bib6 article-title: Clinical and biological aspects of rotator cuff tears publication-title: Muscles Ligaments Tendons J contributor: fullname: Oliva – volume: 8 start-page: 137 year: 1977 end-page: 154 ident: bib8 article-title: Mechanochemical studies of enzymatic degradation of insoluble collagen fibers publication-title: J Biomed Mater Res Symp contributor: fullname: Yannas – volume: 47 start-page: 380 year: 1976 end-page: 390 ident: bib7 article-title: Collagen resorption by fibroblasts publication-title: J Periodontol contributor: fullname: Garant – volume: 759 start-page: 51 year: 2015 end-page: 62 ident: bib11 article-title: Regulatory acceptance of animal models of disease to support clinical trials of medicines and advanced therapy medicinal products publication-title: Eur J Pharmacol contributor: fullname: Silva Lima – volume: 38 start-page: 572 year: 2009 end-page: 575 ident: bib18 article-title: Porcine small intestine submucosa xenograft augmentation in repair of massive rotator cuff tears publication-title: Am J Orthop contributor: fullname: Petersen – start-page: 178 year: 2006 end-page: 179 ident: bib10 article-title: Histology: a text and atlas contributor: fullname: Pawlina – volume: 65 start-page: 308 year: 1983 end-page: 309 ident: bib19 article-title: The clinical, arthroscopic, and histologic findings after replacement of the anterior cruciate ligament with carbon-fibre publication-title: J Bone Joint Surg Br contributor: fullname: Naylor – volume: 49 start-page: 155 year: 2010 end-page: 158 ident: bib20 article-title: Inflammatory reaction to implanted equine pericardium xenograft publication-title: J Foot Ankle Surg contributor: fullname: Hyer – volume: 89 start-page: 786 year: 2007 ident: 10.1016/j.arthro.2016.06.047_bib17 article-title: Restore orthobiologoic implant: not recommended for augmentation of rotator cuff repairs publication-title: J Bone Joint Surg Am contributor: fullname: Walton – start-page: 178 year: 2006 ident: 10.1016/j.arthro.2016.06.047_bib10 contributor: fullname: Ross – start-page: 401 year: 1990 ident: 10.1016/j.arthro.2016.06.047_bib13 article-title: Animal models for knee ligament research contributor: fullname: Arnoczky – volume: 6 start-page: 16 year: 2016 ident: 10.1016/j.arthro.2016.06.047_bib3 article-title: Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up publication-title: Muscles Ligaments Tendons J doi: 10.32098/mltj.01.2016.03 contributor: fullname: Bokor – volume: 5 start-page: 1137 year: 2008 ident: 10.1016/j.arthro.2016.06.047_bib4 article-title: Biomaterials in orthopaedics publication-title: J R Soc Interface doi: 10.1098/rsif.2008.0151 contributor: fullname: Navarro – volume: 29 start-page: 175 year: 2001 ident: 10.1016/j.arthro.2016.06.047_bib14 article-title: Tissue-engineered rotator cuff tendon using porcine small intestine submucosa. Histologic and mechanical evaluation in dogs publication-title: Am J Sports Med doi: 10.1177/03635465010290021001 contributor: fullname: Dejardin – start-page: 67 year: 1986 ident: 10.1016/j.arthro.2016.06.047_bib12 article-title: Experimental surgery of the skeletal system contributor: fullname: Arnoczky – volume: 25 start-page: 329 year: 2009 ident: 10.1016/j.arthro.2016.06.047_bib5 article-title: Histological evaluation of a biopsy specimen obtained 3-month after rotator cuff augmentation with GraftJacket Matrix publication-title: Arthroscopy doi: 10.1016/j.arthro.2008.05.023 contributor: fullname: Snyder – volume: 47 start-page: 380 year: 1976 ident: 10.1016/j.arthro.2016.06.047_bib7 article-title: Collagen resorption by fibroblasts publication-title: J Periodontol doi: 10.1902/jop.1976.47.7.380 contributor: fullname: Garant – volume: 8 start-page: 137 year: 1977 ident: 10.1016/j.arthro.2016.06.047_bib8 article-title: Mechanochemical studies of enzymatic degradation of insoluble collagen fibers publication-title: J Biomed Mater Res Symp doi: 10.1002/jbm.820110113 contributor: fullname: Huang – volume: 759 start-page: 51 year: 2015 ident: 10.1016/j.arthro.2016.06.047_bib11 article-title: Regulatory acceptance of animal models of disease to support clinical trials of medicines and advanced therapy medicinal products publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2015.03.048 contributor: fullname: Cavagnaro – volume: 3 start-page: 229 year: 2013 ident: 10.1016/j.arthro.2016.06.047_bib1 article-title: Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: a histological evaluation in sheep publication-title: Muscles Ligaments Tendons J doi: 10.32098/mltj.03.2013.17 contributor: fullname: Van Kampen – volume: 5 start-page: 144 year: 2015 ident: 10.1016/j.arthro.2016.06.047_bib2 article-title: Preliminary investigation of a biological augmentation of rotator cuff repairs using a collagen implant: a 2-year MRI follow-up publication-title: Muscles Ligaments Tendons J doi: 10.32098/mltj.03.2015.01 contributor: fullname: Bokor – volume: 15 start-page: 802 year: 2014 ident: 10.1016/j.arthro.2016.06.047_bib9 article-title: Mechanotransduction and extracellular matrix homeostasis publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm3896 contributor: fullname: Humphrey – volume: 49 start-page: 155 year: 2010 ident: 10.1016/j.arthro.2016.06.047_bib20 article-title: Inflammatory reaction to implanted equine pericardium xenograft publication-title: J Foot Ankle Surg doi: 10.1053/j.jfas.2009.10.003 contributor: fullname: DeCarbo – volume: 118 start-page: 275 year: 1981 ident: 10.1016/j.arthro.2016.06.047_bib16 article-title: Use of carbon fibers to repair the anterior cruciate ligament of the knee publication-title: J Chir contributor: fullname: Dahhan – volume: 3 start-page: 70 year: 2013 ident: 10.1016/j.arthro.2016.06.047_bib6 article-title: Clinical and biological aspects of rotator cuff tears publication-title: Muscles Ligaments Tendons J contributor: fullname: Via – volume: 65 start-page: 308 year: 1983 ident: 10.1016/j.arthro.2016.06.047_bib19 article-title: The clinical, arthroscopic, and histologic findings after replacement of the anterior cruciate ligament with carbon-fibre publication-title: J Bone Joint Surg Br doi: 10.1302/0301-620X.65B3.6841400 contributor: fullname: Rushton – volume: 34 start-page: 275 year: 2006 ident: 10.1016/j.arthro.2016.06.047_bib15 article-title: The effects of augmentation with swine small intestine submucosa on tendon healing under tension: histologic and mechanical evaluations in sheep publication-title: Am J Sports Med doi: 10.1177/0363546505279912 contributor: fullname: Schlegel – volume: 38 start-page: 572 year: 2009 ident: 10.1016/j.arthro.2016.06.047_bib18 article-title: Porcine small intestine submucosa xenograft augmentation in repair of massive rotator cuff tears publication-title: Am J Orthop contributor: fullname: Phipatanakul |
SSID | ssj0003383 |
Score | 2.4234085 |
Snippet | Purpose To histologically evaluate biopsy specimens from patients who previously underwent rotator cuff repair augmented with a highly porous collagen implant.... To histologically evaluate biopsy specimens from patients who previously underwent rotator cuff repair augmented with a highly porous collagen implant.... PURPOSETo histologically evaluate biopsy specimens from patients who previously underwent rotator cuff repair augmented with a highly porous collagen... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 278 |
SubjectTerms | Absorbable Implants Adult Biopsy Collagen - chemistry Female Fibroblasts - pathology Humans Male Middle Aged Orthopedics Osseointegration Retrospective Studies Rotator Cuff - pathology Rotator Cuff Injuries - surgery Young Adult |
Title | Histologic Evaluation of Biopsy Specimens Obtained After Rotator Cuff Repair Augmented With a Highly Porous Collagen Implant |
URI | https://www.clinicalkey.es/playcontent/1-s2.0-S074980631630456X https://dx.doi.org/10.1016/j.arthro.2016.06.047 https://www.ncbi.nlm.nih.gov/pubmed/27650821 https://search.proquest.com/docview/1859737979 |
Volume | 33 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELZK98IFgXiVl4zELUqV2kkcH9vVwornit1FvVlO6qy6QFL1ceiKv8P_ZMZ20payAvYSVanaOJ4vM58n428IeWV4LLNBkYQxN2UY60SEOtI8lCaPpEmKSNiekR8-psfn8dtxMu50fm5VLa2Web-4-uO-kptYFc6BXXGX7H9Ytv1TOAGfwb5wBAvD8Z9sbDU-rPMKjlrVbqR_o2k9W6xdc_nvsFANPuWYAgByObQ9wT_XS1xsB4erErVIZno6D4arCyvQOQFPgfvdbAnIt3VwUs-xTBYzDOB7KqsnrKudlP5wjt0WcIPLegOgqi6uvjaVZOBSg5P-JiO_8G2wUS96CmN4136HsqBt3-zRfAu9p9OLJl2LghLb-QqIgdFO7Ue7kWanzhOIjIRg6X2d8b6YpSFnPkh4Z-1UMzwo2bbndZ2AfBBnrjvOXnxwqYrLvrbzgpV9qZVvdaqfvylvn-KocFDAWZH5jm-RA9RbjLvk4M3o_ZdhG_J5q_fq7qLZo2kLCfevdR0Hum6NY7nO2V1yxy9S6NAh7h7pmOo--bFBG92gjdYldWijLdpogzZq0UY92iiijTq00RZtFNFGNXVoow5ttEEb9Wh7QM5fH50dHoe-d0dYxClfhkUJoVBoXg5KUWaaR1LLWAJ3LjLgiCUrUyEN6tAKHaWlyQzYmZkM6GY-SDJT8IekW9WVeUyo5IYxY18Ys5jzUsaTiWbgTCYpz4u06JGwmU01cxItqqldvFRu9hXOvsISzlj0iGimXDXbjyFgmoV_shdqoBZMRWrP_tu_9ATVEU8F-PrLNV82tlXgv_GlnK4MzKcCviwFF1LIHnnkjN7eBRO4fmKDJze-7lNye_MMPiPd5XxlngOLXuYvPIZ_ARgkyrg |
link.rule.ids | 314,780,784,27924,27925 |
linkProvider | Elsevier |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Histologic+Evaluation+of+Biopsy+Specimens+Obtained+After+Rotator+Cuff+Repair+Augmented+With+a+Highly+Porous+Collagen+Implant&rft.jtitle=Arthroscopy&rft.au=Arnoczky%2C+Steven+P.&rft.au=Bishai%2C+Shariff+K.&rft.au=Schofield%2C+Brian&rft.au=Sigman%2C+Scott&rft.date=2017-02-01&rft.pub=Elsevier+Inc&rft.issn=0749-8063&rft.eissn=1526-3231&rft.volume=33&rft.issue=2&rft.spage=278&rft.epage=283&rft_id=info:doi/10.1016%2Fj.arthro.2016.06.047&rft.externalDocID=S074980631630456X |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0749-8063&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0749-8063&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0749-8063&client=summon |