The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells

• Published in: Biochimica et biophysica acta Vol. 1843; no. 9; pp. 1969 - 1977
• Main Authors: Ruvolo, Peter P., Ruvolo, Vivian R., Jacamo, Rodrigo, Burks, Jared K., Zeng, Zhihong, Duvvuri, Seshagiri R., Zhou, Liran, Qiu, Yihua, Coombes, Kevin R., Zhang, Nianxiang, Yoo, Suk Y., Pan, Rongqing, Hail, Numsen, Konopleva, Marina, Calin, George, Kornblau, Steven M., Andreeff, Michael
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2014
• Subjects: AML; B55α; Cell signaling; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Fingolimod Hydrochloride; Gene Expression Regulation, Leukemic - drug effects; Humans; Leukemia, Myeloid, Acute - enzymology; Leukemia, Myeloid, Acute - genetics; MicroRNAs - genetics; MicroRNAs - metabolism; miR-142; miR-191; Models, Biological; Phosphorylation - drug effects; Propylene Glycols - pharmacology; Protein Kinase C-alpha - metabolism; Protein Phosphatase 2 - metabolism; Proto-Oncogene Proteins c-myc - metabolism; Relapse; RNA, Small Interfering - metabolism; Signal Transduction - drug effects; Signal Transduction - genetics; Sphingosine - analogs & derivatives; Sphingosine - pharmacology; src-Family Kinases - metabolism; AML; B55α; Relapse; miR-142; PKC; RPPA; PP2A; AKT; Cell signaling; miR-191

We recently discovered that the protein phosphatase 2A (PP2A) B55α subunit (PPP2R2A) is under-expressed in primary blast cells and is unfavorable for remission duration in AML patients. In this study, reverse phase protein analysis (RPPA) of 230 proteins in 511 AML patient samples revealed a strong...