Detection of MRD may predict the outcome of patients with Philadelphia chromosome–positive ALL treated with tyrosine kinase inhibitors plus chemotherapy

• Published in: Blood Vol. 122; no. 7; pp. 1214 - 1221
• Main Authors: Ravandi, Farhad, Jorgensen, Jeffrey L., Thomas, Deborah A., O'Brien, Susan, Garris, Rebecca, Faderl, Stefan, Huang, Xuelin, Wen, Sijin, Burger, Jan A., Ferrajoli, Alessandra, Kebriaei, Partow, Champlin, Richard E., Estrov, Zeev, Challagundla, Pramoda, Wang, Sa A., Luthra, Rajyalakshmi, Cortes, Jorge E., Kantarjian, Hagop M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.08.2013; American Society of Hematology
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Benzamides - administration & dosage; Cyclophosphamide - administration & dosage; Cytarabine - administration & dosage; Dasatinib; Dexamethasone - administration & dosage; Doxorubicin - administration & dosage; Female; Flow Cytometry; Follow-Up Studies; Fusion Proteins, bcr-abl - genetics; Humans; Imatinib Mesylate; Immunoglobulin Heavy Chains - genetics; Lymphoid Neoplasia; Male; Methotrexate - administration & dosage; Middle Aged; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - mortality; Neoplasm Staging; Neoplasm, Residual - diagnosis; Neoplasm, Residual - genetics; Neoplasm, Residual - mortality; Philadelphia Chromosome; Piperazines - administration & dosage; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality; Prednisone - administration & dosage; Prognosis; Pyrimidines - administration & dosage; Real-Time Polymerase Chain Reaction; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Survival Rate; Thiazoles - administration & dosage; Vincristine - administration & dosage; Young Adult

From 2001 to 2011, 122 patients with newly diagnosed Philadelphia chromosome–positive acute lymphoblastic leukemia were treated with chemotherapy + imatinib (n = 54) or + dasatinib (n = 68). One hundred fifteen (94%) achieved complete remission (CR) including 101 patients who achieved it with only 1...