Female reproductive and developmental toxicology: overview and current approaches

In recent years, concern about possible female reproductive and developmental toxicity due to environmental contaminants, such as PCBs, has been growing. Because this area of toxicology had not been emphasized prior to this time, there are many gaps in current knowledge about female developmental an...

Full description

Saved in:
Bibliographic Details
Published inToxicology Letters Vol. 74; no. 2; pp. 99 - 119
Main Authors Kamrin, Michael A., Carney, Edward W., Chou, Karen, Cummings, Audrey, Dostal, Lori A., Harris, Craig, Henck, Judith W., Loch-Caruso, Rita, Miller, Richard K.
Format Book Review Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.11.1994
Amsterdam Elsevier Science
Subjects
Biological and medical sciences
Developmental toxicology
Embryonic and Fetal Development - drug effects
Female
Female reproductive toxicology
Gap Junctions - drug effects
Gap Junctions - ultrastructure
Glutathione - physiology
Hazardous Substances - adverse effects
Humans
In vitro assays
Lactation - drug effects
Lactation - physiology
Male
Maternal Exposure - adverse effects
Medical sciences
Miscellaneous
Paternal Exposure
Placenta - drug effects
Placenta - embryology
Pregnancy
Reproduction - drug effects
Reproduction - physiology
Research Design
Toxicology
Female reproductive toxicology
In vitro assays
Developmental toxicology
Human
Embryonic development
Toxicity
Chemical compound
Early stage
Review
In vitro
Female genital diseases
Pregnancy
In vivo
Reproduction
Animal
Advanced stage
Online AccessGet full text

Cover

More Information
Summary:In recent years, concern about possible female reproductive and developmental toxicity due to environmental contaminants, such as PCBs, has been growing. Because this area of toxicology had not been emphasized prior to this time, there are many gaps in current knowledge about female developmental and reproductive toxicology and only a limited number of validated tests to assay effects of toxicants on various parts of the reproductive and developmental cycle. This article reviews the current state of knowledge on this topic and also explores a variety of techniques for assessing female reproductive and developmental toxicity. These include an assay of the state of intercellular communication among the embryo, fetus and placenta; protocols for assessing toxicity in early pregnancy; and techniques for evaluating the role of glutathione in protecting the conceptus from xenobiotics.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(94)90089-2