MicroRNA-29b Inhibits Angiogenesis by Targeting VEGFA through the MAPK/ERK and PI3K/Akt Signaling Pathways in Endometrial Carcinoma

• Published in: Cellular physiology and biochemistry Vol. 41; no. 3; pp. 933 - 946
• Main Authors: Chen, Hong-Xia, Xu, Xiao-Xia, Tan, Bu-Zhen, Zhang, Zhi, Zhou, Xiao-Dong
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2017; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Androstadienes - pharmacology; Angiogenesis; Animals; Cancer therapies; Cell Line, Tumor; Disease; Endometrial cancer; Endometrial carcinoma; Endometrial Neoplasms - genetics; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Endometrial Neoplasms - therapy; Enzymes; Female; Flavonoids - pharmacology; Gene expression; Gene Expression Regulation, Neoplastic; Genetic Vectors - chemistry; Genetic Vectors - metabolism; Humans; Hypoxia; Kinases; Laboratory animals; Lentivirus - genetics; Lentivirus - metabolism; MAPK/ERK signaling pathway; Medical prognosis; Melanoma; Metastasis; Mice; Mice, Nude; MicroRNA-29b; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases - genetics; Mitogen-Activated Protein Kinase Kinases - metabolism; Morphology; Neoplasm Transplantation; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - pathology; Neovascularization, Pathologic - surgery; Neovascularization, Pathologic - therapy; Original Paper; Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; PI3K/Akt signaling pathway; Plasmids; Protein Kinase Inhibitors - pharmacology; Proteins; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Signal Transduction; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Transfection; Tumorigenesis; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; VEGFA; Wortmannin; China; Angiogenesis; PI3K/Akt signaling pathway; MAPK/ERK signaling pathway; Endometrial carcinoma; MicroRNA-29b; VEGFA

Objective: The purpose of this study is to explore the effects of microRNA-29b (miR-29b) regulating MAPK/ERK and PI3K/Akt signaling pathways on angiogenesis in endometrial carcinoma (EC) by targeting VEGFA. Methods: Between February 2013 and April 2015, 126 EC patients admitted to the Second Affilia...