Effective Population Size Predicts Local Rates but Not Local Mitigation of Read-through Errors

• Published in: Molecular biology and evolution Vol. 38; no. 1; pp. 244 - 262
• Main Authors: Ho, Alexander T, Hurst, Laurence D
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 04.01.2021
• Subjects: Analysis; Codon; Discoveries; Evolution; Gene mutations; Genes; translational read-through; error mitigation; phenotypic error; nearly neutral theory; additional stop codons; molecular evolution

Abstract In correctly predicting that selection efficiency is positively correlated with the effective population size (Ne), the nearly neutral theory provides a coherent understanding of between-species variation in numerous genomic parameters, including heritable error (germline mutation) rates. D...