T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 145; no. 2; pp. 456 - 465
• Main Authors: Krebs, Karin, Böttinger, Nina, Huang, Li–Rung, Chmielewski, Markus, Arzberger, Silke, Gasteiger, Georg, Jäger, Clemens, Schmitt, Edgar, Bohne, Felix, Aichler, Michaela, Uckert, Wolfgang, Abken, Hinrich, Heikenwalder, Mathias, Knolle, Percy, Protzer, Ulrike
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2013
• Subjects: Adoptive T-Cell Therapy; Adoptive Transfer; Animals; CD8-Positive T-Lymphocytes - immunology; Chronic Hepatitis B; Gastroenterology and Hepatology; Hepatitis B virus - immunology; Hepatitis B virus - physiology; Hepatocellular Carcinoma; Humans; Immunotherapy; Liver - immunology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Antigen, T-Cell - immunology; Recombinant Fusion Proteins - immunology; Viral Envelope Proteins - immunology; Virus Replication - immunology; Chronic Hepatitis B; cccDNA; hepatitis B virus; Adoptive T-Cell Therapy; alanine aminotransferase; ALT; chimeric antigen receptor; TNF; IFN; dendritic cells; Immunotherapy; hepatitis B virus transgenic; HBVtg; interleukin; HBV; S-CAR; CEA; Hepatocellular Carcinoma; carcinoembryonic antigen; IL; hepatitis B surface antigen; HBsAg; HCC; interferon; hepatitis B virus–specific chimeric antigen receptor; tumor necrosis factor; CAR; scFv; single-chain fragment variable; covalently closed circular DNA; DC

Background & Aims Antiviral agents suppress hepatitis B virus (HBV) replication but do not clear the infection. A strong effector T-cell response is required to eradicate HBV, but this does not occur in patients with chronic infection. T cells might be directed toward virus-infected cells by exp...