Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain

• Published in: Developmental cell Vol. 56; no. 21; pp. 2952 - 2965.e9
• Main Authors: Krishna, Shefali, Arrojo e Drigo, Rafael, Capitanio, Juliana S., Ramachandra, Ranjan, Ellisman, Mark, Hetzer, Martin W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.11.2021
• Subjects: age mosaicism; aging; Animals; Electron Transport - physiology; electron transport chain; Electron Transport Complex I - metabolism; Electron Transport Complex IV - metabolism; heterogeneity; long-lived proteins; Mice; mitochondria; Mitochondria - metabolism; Mitochondrial Membranes - metabolism; Mitochondrial Proteins - metabolism; muscle; neurons; Oxidative Phosphorylation; protein homeostasis; supercomplexes; electron transport chain; mitochondria; protein homeostasis; muscle; long-lived proteins; supercomplexes; aging; neurons; age mosaicism; heterogeneity

In order to combat molecular damage, most cellular proteins undergo rapid turnover. We have previously identified large nuclear protein assemblies that can persist for years in post-mitotic tissues and are subject to age-related decline. Here, we report that mitochondria can be long lived in the mou...