Outcomes of hematopoietic cell transplantation using donors or recipients with inherited chromosomally integrated HHV-6

• Published in: Blood Vol. 130; no. 8; pp. 1062 - 1069
• Main Authors: Hill, Joshua A., Magaret, Amalia S., Hall-Sedlak, Ruth, Mikhaylova, Anna, Huang, Meei-Li, Sandmaier, Brenda M., Hansen, John A., Jerome, Keith R., Zerr, Danielle M., Boeckh, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.08.2017; American Society of Hematology
• Subjects: Acute Disease; Adult; Chromosomes, Human - genetics; Chromosomes, Human - virology; Chronic Disease; Female; Graft vs Host Disease - genetics; Hematopoietic Stem Cell Transplantation; Herpesvirus 6, Human - genetics; Humans; Incidence; Inheritance Patterns - genetics; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Probability; Proportional Hazards Models; Risk Factors; Tissue Donors; Transplantation; Treatment Outcome

Human herpesvirus 6 (HHV-6) species have a unique ability to integrate into chromosomal telomeres. Mendelian inheritance via gametocyte integration results in HHV-6 in every nucleated cell. The epidemiology and clinical effect of inherited chromosomally integrated HHV-6 (iciHHV-6) in hematopoietic c...