Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

Cardiac metabolism affects systemic energetic balance. Previously, we showed that Krüppel-like factor (KLF)-5 regulates cardiomyocyte PPARα and fatty acid oxidation-related gene expression in diabetes. We surprisingly found that cardiomyocyte-specific KLF5 knockout mice (αMHC-KLF5−/−) have accelerat...

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Published inBiochimica et biophysica acta. Molecular basis of disease Vol. 1865; no. 9; pp. 2125 - 2137
Main Authors Pol, Christine J., Pollak, Nina M., Jurczak, Michael J., Zacharia, Effimia, Karagiannides, Iordanes, Kyriazis, Ioannis D., Ntziachristos, Panagiotis, Scerbo, Diego A., Brown, Brett R., Aifantis, Iannis, Shulman, Gerald I., Goldberg, Ira J., Drosatos, Konstantinos
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2019
Subjects
Adipose Tissue, White - metabolism
Adipose Tissue, White - pathology
Animals
Body Weight
Diet, High-Fat
Female
FGF21
Fibroblast Growth Factors - blood
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - metabolism
Heart
High fat diet
Humans
Kruppel-Like Transcription Factors - genetics
Kruppel-Like Transcription Factors - metabolism
Krüppel-like factor
Leptin - blood
Male
Mediator Complex - genetics
Mediator Complex - metabolism
Mice
Mice, Knockout
MicroRNAs - metabolism
Myocardium - metabolism
Myocytes, Cardiac - cytology
Myocytes, Cardiac - metabolism
Obesity
Obesity - etiology
Signal Transduction
Heart
Obesity
ANP
SUMO
KLF
BNP
HFD
DIO
WAT
18S
RXR
Snord65
Actb
High fat diet
MED13
BAT
FAO
Rplp0
Krüppel-like factor
FGF21
Online AccessGet full text

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Abstract Cardiac metabolism affects systemic energetic balance. Previously, we showed that Krüppel-like factor (KLF)-5 regulates cardiomyocyte PPARα and fatty acid oxidation-related gene expression in diabetes. We surprisingly found that cardiomyocyte-specific KLF5 knockout mice (αMHC-KLF5−/−) have accelerated diet-induced obesity, associated with increased white adipose tissue (WAT). Alterations in cardiac expression of the mediator complex subunit 13 (Med13) modulates obesity. αMHC-KLF5−/− mice had reduced cardiac Med13 expression likely because KLF5 upregulates Med13 expression in cardiomyocytes. We then investigated potential mechanisms that mediate cross-talk between cardiomyocytes and WAT. High fat diet-fed αMHC-KLF5−/− mice had increased levels of cardiac and plasma FGF21, while food intake, activity, plasma leptin, and natriuretic peptides expression were unchanged. Consistent with studies reporting that FGF21 signaling in WAT decreases sumoylation-driven PPARγ inactivation, αMHC-KLF5−/− mice had less SUMO-PPARγ in WAT. Increased diet-induced obesity found in αMHC-KLF5−/− mice was absent in αMHC-[KLF5−/−;FGF21−/−] double knockout mice, as well as in αMHC-FGF21−/− mice that we generated. Thus, cardiomyocyte-derived FGF21 is a component of pro-adipogenic crosstalk between heart and WAT. [Display omitted] •Cardiomyocyte-specific KLF5 deletion accelerates diet-induced obesity.•KLF5 is a positive regulator of Med13 expression.•The proadipogenic effect of KLF5 relies also on non-MED13 mechanisms.•Cardiomyocyte KLF5 regulates systemic metabolism and adiposity via FGF21.
AbstractList Cardiac metabolism affects systemic energetic balance. Previously, we showed that Krüppel-like factor (KLF)-5 regulates cardiomyocyte PPARα and fatty acid oxidation-related gene expression in diabetes. We surprisingly found that cardiomyocyte-specific KLF5 knockout mice ( αMHC-KLF5 −/− ) have accelerated diet-induced obesity, associated with increased white adipose tissue (WAT). Alterations in cardiac expression of the mediator complex subunit 13 ( Med13 ) modulates obesity. αMHC-KLF5 −/− mice had reduced cardiac Med13 expression likely because KLF5 upregulates Med13 expression in cardiomyocytes. We then investigated potential mechanisms that mediate cross-talk between cardiomyocytes and WAT. High fat diet-fed αMHC-KLF5 −/− mice had increased levels of cardiac and plasma FGF21, while food intake, activity, plasma leptin, and natriuretic peptides expression were unchanged. Consistent with studies reporting that FGF21 signaling in WAT decreases sumoylation-driven PPARγ inactivation, αMHC-KLF5 −/− mice had less SUMO-PPARγ in WAT. Increased diet-induced obesity found in αMHC-KLF5 −/− mice was absent in αMHC-[KLF5 −/− ;FGF21 −/− ] double knockout mice, as well as in αMHC-FGF21 −/− mice that we generated. Thus, cardiomyocyte-derived FGF21 is a component of pro-adipogenic crosstalk between heart and WAT.
Cardiac metabolism affects systemic energetic balance. Previously, we showed that Krüppel-like factor (KLF)-5 regulates cardiomyocyte PPARα and fatty acid oxidation-related gene expression in diabetes. We surprisingly found that cardiomyocyte-specific KLF5 knockout mice (αMHC-KLF5−/−) have accelerated diet-induced obesity, associated with increased white adipose tissue (WAT). Alterations in cardiac expression of the mediator complex subunit 13 (Med13) modulates obesity. αMHC-KLF5−/− mice had reduced cardiac Med13 expression likely because KLF5 upregulates Med13 expression in cardiomyocytes. We then investigated potential mechanisms that mediate cross-talk between cardiomyocytes and WAT. High fat diet-fed αMHC-KLF5−/− mice had increased levels of cardiac and plasma FGF21, while food intake, activity, plasma leptin, and natriuretic peptides expression were unchanged. Consistent with studies reporting that FGF21 signaling in WAT decreases sumoylation-driven PPARγ inactivation, αMHC-KLF5−/− mice had less SUMO-PPARγ in WAT. Increased diet-induced obesity found in αMHC-KLF5−/− mice was absent in αMHC-[KLF5−/−;FGF21−/−] double knockout mice, as well as in αMHC-FGF21−/− mice that we generated. Thus, cardiomyocyte-derived FGF21 is a component of pro-adipogenic crosstalk between heart and WAT. [Display omitted] •Cardiomyocyte-specific KLF5 deletion accelerates diet-induced obesity.•KLF5 is a positive regulator of Med13 expression.•The proadipogenic effect of KLF5 relies also on non-MED13 mechanisms.•Cardiomyocyte KLF5 regulates systemic metabolism and adiposity via FGF21.
Cardiac metabolism affects systemic energetic balance. Previously, we showed that Krüppel-like factor (KLF)-5 regulates cardiomyocyte PPARα and fatty acid oxidation-related gene expression in diabetes. We surprisingly found that cardiomyocyte-specific KLF5 knockout mice (αMHC-KLF5 ) have accelerated diet-induced obesity, associated with increased white adipose tissue (WAT). Alterations in cardiac expression of the mediator complex subunit 13 (Med13) modulates obesity. αMHC-KLF5 mice had reduced cardiac Med13 expression likely because KLF5 upregulates Med13 expression in cardiomyocytes. We then investigated potential mechanisms that mediate cross-talk between cardiomyocytes and WAT. High fat diet-fed αMHC-KLF5 mice had increased levels of cardiac and plasma FGF21, while food intake, activity, plasma leptin, and natriuretic peptides expression were unchanged. Consistent with studies reporting that FGF21 signaling in WAT decreases sumoylation-driven PPARγ inactivation, αMHC-KLF5 mice had less SUMO-PPARγ in WAT. Increased diet-induced obesity found in αMHC-KLF5 mice was absent in αMHC-[KLF5 ;FGF21 ] double knockout mice, as well as in αMHC-FGF21 mice that we generated. Thus, cardiomyocyte-derived FGF21 is a component of pro-adipogenic crosstalk between heart and WAT.
Author Brown, Brett R.
Goldberg, Ira J.
Kyriazis, Ioannis D.
Scerbo, Diego A.
Pollak, Nina M.
Ntziachristos, Panagiotis
Shulman, Gerald I.
Drosatos, Konstantinos
Karagiannides, Iordanes
Pol, Christine J.
Jurczak, Michael J.
Zacharia, Effimia
Aifantis, Iannis
AuthorAffiliation e Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY, USA
c Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA
b Institute of Molecular Biosciences, University of Graz, Graz, Austria
a Metabolic Biology Laboratory, Lewis Katz School of Medicine at Temple University, Center for Translational Medicine, Department of Pharmacology, Philadelphia, USA
f Division of Preventive Medicine and Nutrition, Columbia University, New York, NY 10032, USA
d Inflammatory Bowel Disease Center and Neuroendocrine Assay Core, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
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Cites_doi 10.1210/en.2009-0532
10.1016/j.cmet.2013.03.019
10.1016/j.cmet.2013.04.005
10.1210/me.2010-0142
10.1210/jc.2011-1182
10.1016/j.celrep.2019.02.014
10.1126/scisignal.aam6870
10.1530/EC-14-0012
10.1016/j.cmet.2014.02.004
10.2337/diabetes.54.9.2514
10.1074/jbc.M103382200
10.15252/emmm.201404218
10.2337/db14-0595
10.1172/JCI59701
10.1111/j.1469-7793.1998.949bp.x
10.1016/j.cmet.2013.08.005
10.1161/01.CIR.0000112582.16683.EA
10.1038/358771a0
10.1016/j.cell.2012.03.029
10.1038/onc.2009.235
10.1161/CIRCRESAHA.116.306842
10.1210/en.2012-1846
10.1038/nm.3994
10.1016/j.cmet.2016.02.001
10.1002/jcp.20847
10.1016/j.ebiom.2016.10.020
10.1093/hmg/ddt393
10.1042/BJ20100749
10.1016/j.cmet.2012.08.002
10.1016/S0167-4781(00)00067-1
10.1371/journal.pone.0087102
10.1210/jc.2004-1953
10.1111/apha.12686
10.1073/pnas.95.6.2979
10.1016/j.jacc.2009.02.038
10.1128/MCB.00992-07
10.1016/j.febslet.2009.09.012
10.1194/jlr.M044784
10.1101/gad.177857.111
10.1016/j.cmet.2017.03.005
10.15252/embj.201696179
10.2337/db08-0392
10.1161/CIRCULATIONAHA.111.044255
10.1016/j.cmet.2007.05.002
10.1016/j.cmet.2017.09.005
10.1016/j.molmet.2013.05.005
10.1152/ajpendo.00111.2006
10.1038/ncomms3019
10.1016/j.molmet.2013.12.002
10.1074/jbc.M110.215889
10.1038/nm.3014
10.2337/db10-0193
10.1371/journal.pone.0148252
10.1074/jbc.M111.316760
10.1161/JAHA.115.002553
10.1371/journal.pgen.1006555
10.1016/j.cell.2011.11.062
10.1371/journal.pone.0001765
10.1124/mol.108.044826
10.1074/jbc.M401028200
10.2337/diabetes.48.4.699
10.1096/fasebj.14.10.1345
10.1016/j.cmet.2007.05.003
10.1161/CIRCRESAHA.115.306383
10.1016/S0002-9440(10)65577-0
10.1016/j.molmet.2012.08.007
10.1002/emmm.201302852
10.1146/annurev.biochem.77.061307.091829
10.1016/j.febslet.2008.10.021
10.1210/en.2012-2144
10.1016/j.cmet.2016.12.004
10.1074/jbc.M111.272146
10.1172/JCI23606
10.1210/en.2015-1722
10.1007/s00018-016-2420-x
10.1016/j.febslet.2008.04.038
10.1371/journal.pone.0049977
10.1161/CIRCULATIONAHA.105.555573
10.1161/CIRCHEARTFAILURE.112.000177
10.1016/j.bbadis.2012.03.014
10.1038/nm1756
10.1101/gad.1767009
10.1210/en.2008-0816
10.1073/pnas.1409427111
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Issue 9
Keywords Heart
Obesity
ANP
SUMO
KLF
BNP
HFD
DIO
WAT
18S
RXR
Snord65
Actb
High fat diet
MED13
BAT
FAO
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Krüppel-like factor
FGF21
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Notes Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Conceptualization K.D., C.J.P.; Methodology, K.D., C.J.P., N.M.P., E.Z., I.D.K., P.N.; Validation, C.J.P., N.M.P.; Formal Analysis, C.J.P., N.M.P., M.J.J., E.Z., I.D.K., I.K.; Investigation, C.J.P, N.M.P., M.J.J., E.Z., I.K., I.D.K., D.A.S, B.R.B., and K.D.; Resources, K.D., I.J.G., G.I.S., I.A.; Writing - Original Draft, C.J.P., K.D.; Writing - Review & Editing, C.J.P., N.M.P., M.J.J., E.Z., I.K., I.D.K., P.N., I.A., G.I.S., I.J.G., K.D.; Supervision K.D.; Project administration, C.J.P., K.D.; Funding Acquisition, K.D, I.J.G., I.A., P.N.
Division of Endocrinology, Diabetes & Metabolism, NYU-Langone School of Medicine, New York, NY, USA.
Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
AUTHOR CONTRIBUTIONS
Genecology Research Centre, School of Science and Engineering, University of the Sunshine Coast, Queensland, Australia, CSIRO Synthetic Biology Future Science Platform, Australian Institute for Bioengineering and Nanotechnology, School of Chemistry and Molecular Biosciences, University of Queensland, Queensland, Australia
Department of Biochemistry and Molecular Genetics and Robert H. Lurie Comprehensive Cancer Center Northwestern University, Chicago, IL
ORCID 0000-0003-0903-834X
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614009
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References Moyers, Shiyanova, Mehrbod, Dunbar, Noblitt, Otto, Reifel-Miller, Kharitonenkov (bb0415) 2007; 210
Izumiya, Bina, Ouchi, Akasaki, Kharitonenkov, Walsh (bb0120) 2008; 582
Klemm, Leitner, Watson, Nesterova, Reusch, Goalstone, Draznin (bb0410) 2001; 276
Wu, Shi, Liu, Ceddia, Gaffin, Wei, Fang, Lewandowski, Collins (bb0280) 2017; 10
Inagaki, Dutchak, Zhao, Ding, Gautron, Parameswara, Li, Goetz, Mohammadi, Esser (bb0160) 2007; 5
Geng, Liao, Jin, Huang, Triggle, Ding, Zhang, Huang, Lin, Xu (bb0180) 2019; 26
Fisher, Maratos-Flier (bb0425) 2014; 3
Brahma, Adam, Pollak, Jaeger, Zierler, Pocher, Schreiber, Romauch, Moustafa, Eder (bb0205) 2014; 55
Tsukamoto, Fujita, Kato, Yamazaki, Asano, Ogai, Okazaki, Asai, Nagamachi, Maeda (bb0030) 2009; 53
Raake, P.W., Zhang, X., Vinge, L.E., Brinks, H., Gao, E., Jaleel, N., Li, Y., Tang, M., Most, P., Dorn, G.W., 2nd, et al. 2012. Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction. Circulation 125:2108–2118.
Dogan, Pujol, Maiti, Kukat, Wang, Hermans, Senft, Wibom, Rugarli, Trifunovic (bb0360) 2014; 19
Tontonoz, Spiegelman (bb0065) 2008; 77
Ding, Boney-Montoya, Owen, Bookout, Coate, Mangelsdorf, Kliewer (bb0150) 2012; 16
Mikkonen, Hirvonen, Janne (bb0230) 2013; 154
Noh, Okajima, Molkentin, Homma, Goldberg (bb0275) 2006; 291
Suarez-Zamorano, Fabbiano, Chevalier, Stojanovic, Colin, Stevanovic, Veyrat-Durebex, Tarallo, Rigo, Germain (bb0330) 2015; 21
Augustus, Yagyu, Haemmerle, Bensadoun, Vikramadithyan, Park, Kim, Zechner, Goldberg (bb0010) 2004; 279
Bordicchia, Liu, Amri, Ailhaud, Dessi-Fulgheri, Zhang, Takahashi, Sarzani, Collins (bb0035) 2012; 122
Claycomb, Lanson, Stallworth, Egeland, Delcarpio, Bahinski, Izzo (bb0245) 1998; 95
Muise, Azzolina, Kuo, El-Sherbeini, Tan, Yuan, Mu, Thompson, Berger, Wong (bb0100) 2008; 74
Park, Cho, Finck, Kim, Higashimori, Hong, Lee, Danton, Deshmukh, Cline (bb0350) 2005; 54
Xu, Lloyd, Hale, Stanislaus, Chen, Sivits, Vonderfecht, Hecht, Li, Lindberg (bb0395) 2009; 58
Kharitonenkov, Shiyanova, Koester, Ford, Micanovic, Galbreath, Sandusky, Hammond, Moyers, Owens (bb0185) 2005; 115
Kim, Jeong, Oh, Kim, Cho, Kim, Kim, Kim, Hur, Kim (bb0335) 2013; 19
Lan, Morgan, Rahmouni, Sonoda, Fu, Burgess, Holland, Kliewer, Mangelsdorf (bb0405) 2017; 26
Lee, Bao, Ishikawa, Wang, Lim (bb0345) 2017; 13
Das, Drazner, Dries, Vega, Stanek, Abdullah, Canham, Chung, Leonard, Wians (bb0285) 2005; 112
Lin, Tian, Lam, Lin, Hoo, Konishi, Itoh, Wang, Bornstein, Xu (bb0375) 2013; 17
Ogawa, de Bold (bb0015) 2014; 3
Oishi, Manabe, Tobe, Ohsugi, Kubota, Fujiu, Maemura, Kubota, Kadowaki, Nagai (bb0240) 2008; 14
Zheng, Zhou, Huang, Chaudhury, Dong, Chen (bb0265) 2009; 28
Lee, Bassel-Duby, Olson (bb0340) 2014; 111
Jurczak, Lee, Jornayvaz, Lee, Birkenfeld, Guigni, Kahn, Samuel, Glimcher, Shulman (bb0255) 2012; 287
Schulze, Drosatos, Goldberg (bb0005) 2016; 118
Fisher, Kleiner, Douris, Fox, Mepani, Verdeguer, Wu, Kharitonenkov, Flier, Maratos-Flier (bb0170) 2012; 26
Chung, Ahn, Kim, Kho, Jung, Park (bb0225) 2011; 433
Adams, Yang, Coskun, Cheng, Gimeno, Luo, Kharitonenkov (bb0370) 2012; 2
Hernandez-Anzaldo, Berry, Brglez, Leung, Yun, Lee, Filep, Kassiri, Cheong, Lambeau (bb0045) 2015; 4
BonDurant, Ameka, Naber, Markan, Idiga, Acevedo, Walsh, Ornitz, Potthoff (bb0365) 2017; 25
Adams, Coskun, Cheng, LS, Dubois, Kharitonenkov (bb0420) 2013; 2
Ostrowski, Rohde, Zacho, Asp, Pedersen (bb0325) 1998; 508
Fon Tacer, Bookout, Ding, Kurosu, John, Wang, Goetz, Mohammadi, Kuro-o, Mangelsdorf (bb0115) 2010; 24
Baskin, Grueter, Kusminski, Holland, Bookout, Satapati, Kong, Burgess, Malloy, Scherer (bb0050) 2014; 6
Wang, Larson, Levy, Benjamin, Leip, Wilson, Vasan (bb0290) 2004; 109
Arner, Pettersson, Mitchell, Dunbar, Kharitonenkov, Ryden (bb0210) 2008; 582
Patel, Adya, Chen, Ramanjaneya, Bari, Bhudia, Hillhouse, Tan, Randeva (bb0145) 2014; 9
Drosatos, Pollak, Pol, Ntziachristos, Willecke, Valenti, Trent, Hu, Guo, Aifantis (bb0235) 2016; 118
Singhal, Fisher, Chee, Tan, El Ouaamari, Adams, Najarian, Kulkarni, Benoist, Flier (bb0130) 2016; 11
Rieusset, Andreelli, Auboeuf, Roques, Vallier, Riou, Auwerx, Laville, Vidal (bb0070) 1999; 48
Coate, Hernandez, Thorne, Sun, Le, Vale, Kliewer, Mangelsdorf (bb0135) 2017; 25
Pereira, Tadinada, Zasadny, Oliveira, Pires, Olvera, Jeffers, Souvenir, McGlauflin, Seei (bb0305) 2017; 36
Badman, Koester, Flier, Kharitonenkov, Maratos-Flier (bb0400) 2009; 150
Jain, Pulikuri, Zhu, Qi, Kanwar, Yeldandi, Rao, Reddy (bb0075) 1998; 153
Hennige, Staiger, Wicke, Machicao, Fritsche, Haring, Stefan (bb0300) 2008; 3
Dutchak, Katafuchi, Bookout, Choi, Yu, Mangelsdorf, Kliewer (bb0220) 2012; 148
Desvergne, Wahli (bb0080) 1999; 20
Khan, Cheng, Magnusson, Larson, Newton-Cheh, McCabe, Coviello, Florez, Fox, Levy (bb0295) 2011; 96
Talukdar, Zhou, Li, Rossulek, Dong, Somayaji, Weng, Clark, Lanba, Owen (bb0390) 2016; 23
Kliewer, Umesono, Noonan, Heyman, Evans (bb0085) 1992; 358
Li, Ge, Weiszmann, Hecht, Li, Veniant, Xu, Wu, Lindberg, Li (bb0215) 2009; 583
Markan, Naber, Ameka, Anderegg, Mangelsdorf, Kliewer, Mohammadi, Potthoff (bb0355) 2014; 63
Holland, Adams, Brozinick, Bui, Miyauchi, Kusminski, Bauer, Wade, Singhal, Cheng (bb0380) 2013; 17
Rodriguez, Becerril, Ezquerro, Mendez-Gimenez, Fruhbeck (bb0320) 2017; 219
Adams, Cheng, Coskun, Kharitonenkov (bb0155) 2012; 7
Floyd, Stephens (bb0090) 2012; 1822
Nishimura, Nakatake, Konishi, Itoh (bb0095) 2000; 1492
Gaich, Chien, Fu, Glass, Deeg, Holland, Kharitonenkov, Bumol, Schilske, Moller (bb0195) 2013; 18
Magida, Leinwand (bb0040) 2014; 6
Samms, Cheng, Kharitonenkov, Gimeno, Adams (bb0385) 2016; 157
Grueter, van Rooij, Johnson, DeLeon, Sutherland, Qi, Gautron, Elmquist, Bassel-Duby, Olson (bb0055) 2012; 149
Crooks, Natarajan, Jeong, Chen, Park, Huang, Ghosh, Tong, Haller, Wu (bb0125) 2014; 23
Coskun, Bina, Schneider, Dunbar, Hu, Chen, Moller, Kharitonenkov (bb0190) 2008; 149
Wang, Qiang, Farmer (bb0105) 2008; 28
Sengenes, Berlan, De Glisezinski, Lafontan, Galitzky (bb0020) 2000; 14
Drosatos, Drosatos-Tampakaki, Khan, Homma, Schulze, Zannis, Goldberg (bb0260) 2011; 286
Planavila, Redondo, Hondares, Vinciguerra, Munts, Iglesias, Gabrielli, Sitges, Giralt, van Bilsen (bb0140) 2013; 4
Badman, Pissios, Kennedy, Koukos, Flier, Maratos-Flier (bb0165) 2007; 5
Wang, Yang (bb0315) 2017; 74
Fisher, Chui, Antonellis, Bina, Kharitonenkov, Flier, Maratos-Flier (bb0175) 2010; 59
Birkenfeld, Boschmann, Moro, Adams, Heusser, Franke, Berlan, Luft, Lafontan, Jordan (bb0025) 2005; 90
Hondares, Iglesias, Giralt, Gonzalez, Giralt, Mampel, Villarroya (bb0110) 2011; 286
Krievina, Tretjakovs, Skuja, Silina, Keisa, Krievina, Bahs (bb0200) 2016; 13
Drosatos, Khan, Trent, Jiang, Son, Blaner, Homma, Schulze, Goldberg (bb0270) 2013; 6
Knuesel, Meyer, Bernecky, Taatjes (bb0060) 2009; 23
Zhou, Li, Xu, Zang, Wu, Sun (bb0310) 2013; 154
Drosatos (10.1016/j.bbadis.2019.04.010_bb0235) 2016; 118
Fisher (10.1016/j.bbadis.2019.04.010_bb0175) 2010; 59
Krievina (10.1016/j.bbadis.2019.04.010_bb0200) 2016; 13
Patel (10.1016/j.bbadis.2019.04.010_bb0145) 2014; 9
10.1016/j.bbadis.2019.04.010_bb0250
Gaich (10.1016/j.bbadis.2019.04.010_bb0195) 2013; 18
Adams (10.1016/j.bbadis.2019.04.010_bb0155) 2012; 7
Oishi (10.1016/j.bbadis.2019.04.010_bb0240) 2008; 14
Wu (10.1016/j.bbadis.2019.04.010_bb0280) 2017; 10
Zhou (10.1016/j.bbadis.2019.04.010_bb0310) 2013; 154
Noh (10.1016/j.bbadis.2019.04.010_bb0275) 2006; 291
Floyd (10.1016/j.bbadis.2019.04.010_bb0090) 2012; 1822
Nishimura (10.1016/j.bbadis.2019.04.010_bb0095) 2000; 1492
Rieusset (10.1016/j.bbadis.2019.04.010_bb0070) 1999; 48
Geng (10.1016/j.bbadis.2019.04.010_bb0180) 2019; 26
Wang (10.1016/j.bbadis.2019.04.010_bb0315) 2017; 74
Arner (10.1016/j.bbadis.2019.04.010_bb0210) 2008; 582
Jurczak (10.1016/j.bbadis.2019.04.010_bb0255) 2012; 287
Lee (10.1016/j.bbadis.2019.04.010_bb0345) 2017; 13
Desvergne (10.1016/j.bbadis.2019.04.010_bb0080) 1999; 20
Crooks (10.1016/j.bbadis.2019.04.010_bb0125) 2014; 23
BonDurant (10.1016/j.bbadis.2019.04.010_bb0365) 2017; 25
Kliewer (10.1016/j.bbadis.2019.04.010_bb0085) 1992; 358
Li (10.1016/j.bbadis.2019.04.010_bb0215) 2009; 583
Lan (10.1016/j.bbadis.2019.04.010_bb0405) 2017; 26
Baskin (10.1016/j.bbadis.2019.04.010_bb0050) 2014; 6
Wang (10.1016/j.bbadis.2019.04.010_bb0290) 2004; 109
Das (10.1016/j.bbadis.2019.04.010_bb0285) 2005; 112
Rodriguez (10.1016/j.bbadis.2019.04.010_bb0320) 2017; 219
Suarez-Zamorano (10.1016/j.bbadis.2019.04.010_bb0330) 2015; 21
Fisher (10.1016/j.bbadis.2019.04.010_bb0170) 2012; 26
Claycomb (10.1016/j.bbadis.2019.04.010_bb0245) 1998; 95
Adams (10.1016/j.bbadis.2019.04.010_bb0370) 2012; 2
Park (10.1016/j.bbadis.2019.04.010_bb0350) 2005; 54
Izumiya (10.1016/j.bbadis.2019.04.010_bb0120) 2008; 582
Wang (10.1016/j.bbadis.2019.04.010_bb0105) 2008; 28
Xu (10.1016/j.bbadis.2019.04.010_bb0395) 2009; 58
Lin (10.1016/j.bbadis.2019.04.010_bb0375) 2013; 17
Ostrowski (10.1016/j.bbadis.2019.04.010_bb0325) 1998; 508
Lee (10.1016/j.bbadis.2019.04.010_bb0340) 2014; 111
Dutchak (10.1016/j.bbadis.2019.04.010_bb0220) 2012; 148
Fon Tacer (10.1016/j.bbadis.2019.04.010_bb0115) 2010; 24
Grueter (10.1016/j.bbadis.2019.04.010_bb0055) 2012; 149
Ding (10.1016/j.bbadis.2019.04.010_bb0150) 2012; 16
Brahma (10.1016/j.bbadis.2019.04.010_bb0205) 2014; 55
Kim (10.1016/j.bbadis.2019.04.010_bb0335) 2013; 19
Coate (10.1016/j.bbadis.2019.04.010_bb0135) 2017; 25
Samms (10.1016/j.bbadis.2019.04.010_bb0385) 2016; 157
Kharitonenkov (10.1016/j.bbadis.2019.04.010_bb0185) 2005; 115
Adams (10.1016/j.bbadis.2019.04.010_bb0420) 2013; 2
Bordicchia (10.1016/j.bbadis.2019.04.010_bb0035) 2012; 122
Schulze (10.1016/j.bbadis.2019.04.010_bb0005) 2016; 118
Ogawa (10.1016/j.bbadis.2019.04.010_bb0015) 2014; 3
Jain (10.1016/j.bbadis.2019.04.010_bb0075) 1998; 153
Knuesel (10.1016/j.bbadis.2019.04.010_bb0060) 2009; 23
Muise (10.1016/j.bbadis.2019.04.010_bb0100) 2008; 74
Birkenfeld (10.1016/j.bbadis.2019.04.010_bb0025) 2005; 90
Markan (10.1016/j.bbadis.2019.04.010_bb0355) 2014; 63
Singhal (10.1016/j.bbadis.2019.04.010_bb0130) 2016; 11
Talukdar (10.1016/j.bbadis.2019.04.010_bb0390) 2016; 23
Drosatos (10.1016/j.bbadis.2019.04.010_bb0270) 2013; 6
Magida (10.1016/j.bbadis.2019.04.010_bb0040) 2014; 6
Coskun (10.1016/j.bbadis.2019.04.010_bb0190) 2008; 149
Khan (10.1016/j.bbadis.2019.04.010_bb0295) 2011; 96
Pereira (10.1016/j.bbadis.2019.04.010_bb0305) 2017; 36
Dogan (10.1016/j.bbadis.2019.04.010_bb0360) 2014; 19
Hondares (10.1016/j.bbadis.2019.04.010_bb0110) 2011; 286
Inagaki (10.1016/j.bbadis.2019.04.010_bb0160) 2007; 5
Mikkonen (10.1016/j.bbadis.2019.04.010_bb0230) 2013; 154
Moyers (10.1016/j.bbadis.2019.04.010_bb0415) 2007; 210
Fisher (10.1016/j.bbadis.2019.04.010_bb0425) 2014; 3
Tontonoz (10.1016/j.bbadis.2019.04.010_bb0065) 2008; 77
Planavila (10.1016/j.bbadis.2019.04.010_bb0140) 2013; 4
Drosatos (10.1016/j.bbadis.2019.04.010_bb0260) 2011; 286
Klemm (10.1016/j.bbadis.2019.04.010_bb0410) 2001; 276
Hernandez-Anzaldo (10.1016/j.bbadis.2019.04.010_bb0045) 2015; 4
Zheng (10.1016/j.bbadis.2019.04.010_bb0265) 2009; 28
Chung (10.1016/j.bbadis.2019.04.010_bb0225) 2011; 433
Hennige (10.1016/j.bbadis.2019.04.010_bb0300) 2008; 3
Badman (10.1016/j.bbadis.2019.04.010_bb0165) 2007; 5
Holland (10.1016/j.bbadis.2019.04.010_bb0380) 2013; 17
Sengenes (10.1016/j.bbadis.2019.04.010_bb0020) 2000; 14
Badman (10.1016/j.bbadis.2019.04.010_bb0400) 2009; 150
Augustus (10.1016/j.bbadis.2019.04.010_bb0010) 2004; 279
Tsukamoto (10.1016/j.bbadis.2019.04.010_bb0030) 2009; 53
References_xml – volume: 25
  start-page: 935
  year: 2017
  end-page: 944 e934
  ident: bb0365
  article-title: FGF21 regulates metabolism through adipose-dependent and -independent mechanisms
  publication-title: Cell Metab.
  contributor:
    fullname: Potthoff
– volume: 433
  start-page: 155
  year: 2011
  end-page: 161
  ident: bb0225
  article-title: SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor gamma in C2C12 myotubes
  publication-title: Biochem. J.
  contributor:
    fullname: Park
– volume: 25
  start-page: 472
  year: 2017
  end-page: 480
  ident: bb0135
  article-title: FGF21 is an exocrine pancreas secretagogue
  publication-title: Cell Metab.
  contributor:
    fullname: Mangelsdorf
– volume: 153
  start-page: 349
  year: 1998
  end-page: 354
  ident: bb0075
  article-title: Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse
  publication-title: Am. J. Pathol.
  contributor:
    fullname: Reddy
– volume: 90
  start-page: 3622
  year: 2005
  end-page: 3628
  ident: bb0025
  article-title: Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans
  publication-title: J. Clin. Endocrinol. Metab.
  contributor:
    fullname: Jordan
– volume: 18
  start-page: 333
  year: 2013
  end-page: 340
  ident: bb0195
  article-title: The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
  publication-title: Cell Metab.
  contributor:
    fullname: Moller
– volume: 26
  start-page: 709
  year: 2017
  end-page: 718 e703
  ident: bb0405
  article-title: FGF19, FGF21, and an FGFR1/beta-klotho-activating antibody act on the nervous system to regulate body weight and glycemia
  publication-title: Cell Metab.
  contributor:
    fullname: Mangelsdorf
– volume: 358
  start-page: 771
  year: 1992
  end-page: 774
  ident: bb0085
  article-title: Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
  publication-title: Nature
  contributor:
    fullname: Evans
– volume: 7
  year: 2012
  ident: bb0155
  article-title: FGF21 requires betaklotho to act in vivo
  publication-title: PLoS One
  contributor:
    fullname: Kharitonenkov
– volume: 19
  start-page: 458
  year: 2014
  end-page: 469
  ident: bb0360
  article-title: Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart
  publication-title: Cell Metab.
  contributor:
    fullname: Trifunovic
– volume: 6
  start-page: 550
  year: 2013
  end-page: 562
  ident: bb0270
  article-title: Peroxisome proliferator-activated receptor-gamma activation prevents sepsis-related cardiac dysfunction and mortality in mice
  publication-title: Circ. Heart Fail.
  contributor:
    fullname: Goldberg
– volume: 13
  year: 2017
  ident: bb0345
  article-title: Cardiomyocyte regulation of systemic lipid metabolism by the apolipoprotein B-containing lipoproteins in drosophila
  publication-title: PLoS Genet.
  contributor:
    fullname: Lim
– volume: 74
  start-page: 1765
  year: 2017
  end-page: 1776
  ident: bb0315
  article-title: Inter-organ regulation of adipose tissue browning. Cellular and molecular life sciences
  publication-title: CMLS
  contributor:
    fullname: Yang
– volume: 3
  year: 2008
  ident: bb0300
  article-title: Fetuin-a induces cytokine expression and suppresses adiponectin production
  publication-title: PLoS One
  contributor:
    fullname: Stefan
– volume: 17
  start-page: 790
  year: 2013
  end-page: 797
  ident: bb0380
  article-title: An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
  publication-title: Cell Metab.
  contributor:
    fullname: Cheng
– volume: 13
  start-page: 274
  year: 2016
  end-page: 283
  ident: bb0200
  article-title: Ectopic adipose tissue storage in the left and the right renal sinus is asymmetric and associated with serum kidney injury molecule-1 and fibroblast growth factor-21 levels increase
  publication-title: EBioMedicine
  contributor:
    fullname: Bahs
– volume: 3
  start-page: R31
  year: 2014
  end-page: R44
  ident: bb0015
  article-title: The heart as an endocrine organ
  publication-title: Endocr Connect
  contributor:
    fullname: de Bold
– volume: 287
  start-page: 2558
  year: 2012
  end-page: 2567
  ident: bb0255
  article-title: Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Shulman
– volume: 112
  start-page: 2163
  year: 2005
  end-page: 2168
  ident: bb0285
  article-title: Impact of body mass and body composition on circulating levels of natriuretic peptides: results from the Dallas Heart Study
  publication-title: Circulation
  contributor:
    fullname: Wians
– volume: 63
  start-page: 4057
  year: 2014
  end-page: 4063
  ident: bb0355
  article-title: Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding
  publication-title: Diabetes
  contributor:
    fullname: Potthoff
– volume: 1492
  start-page: 203
  year: 2000
  end-page: 206
  ident: bb0095
  article-title: Identification of a novel FGF, FGF-21, preferentially expressed in the liver
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Itoh
– volume: 59
  start-page: 2781
  year: 2010
  end-page: 2789
  ident: bb0175
  article-title: Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
  publication-title: Diabetes
  contributor:
    fullname: Maratos-Flier
– volume: 28
  start-page: 3702
  year: 2009
  end-page: 3713
  ident: bb0265
  article-title: Kruppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1
  publication-title: Oncogene
  contributor:
    fullname: Chen
– volume: 9
  year: 2014
  ident: bb0145
  article-title: Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts
  publication-title: PLoS One
  contributor:
    fullname: Randeva
– volume: 582
  start-page: 3805
  year: 2008
  end-page: 3810
  ident: bb0120
  article-title: FGF21 is an Akt-regulated myokine
  publication-title: FEBS Lett.
  contributor:
    fullname: Walsh
– volume: 11
  year: 2016
  ident: bb0130
  article-title: Fibroblast growth factor 21 (FGF21) protects against high fat diet induced inflammation and islet hyperplasia in pancreas
  publication-title: PLoS One
  contributor:
    fullname: Flier
– volume: 48
  start-page: 699
  year: 1999
  end-page: 705
  ident: bb0070
  article-title: Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes
  publication-title: Diabetes
  contributor:
    fullname: Vidal
– volume: 1822
  start-page: 1090
  year: 2012
  end-page: 1095
  ident: bb0090
  article-title: Controlling a master switch of adipocyte development and insulin sensitivity: covalent modifications of PPARgamma
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Stephens
– volume: 95
  start-page: 2979
  year: 1998
  end-page: 2984
  ident: bb0245
  article-title: HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Izzo
– volume: 23
  start-page: 24
  year: 2014
  end-page: 39
  ident: bb0125
  article-title: Elevated FGF21 secretion, PGC-1alpha and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle
  publication-title: Hum. Mol. Genet.
  contributor:
    fullname: Wu
– volume: 109
  start-page: 594
  year: 2004
  end-page: 600
  ident: bb0290
  article-title: Impact of obesity on plasma natriuretic peptide levels
  publication-title: Circulation
  contributor:
    fullname: Vasan
– volume: 219
  start-page: 362
  year: 2017
  end-page: 381
  ident: bb0320
  article-title: Crosstalk between adipokines and myokines in fat browning
  publication-title: Acta Physiol. (Oxford)
  contributor:
    fullname: Fruhbeck
– volume: 6
  start-page: 482
  year: 2014
  end-page: 495
  ident: bb0040
  article-title: Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy
  publication-title: EMBO Mol. Med.
  contributor:
    fullname: Leinwand
– volume: 149
  start-page: 671
  year: 2012
  end-page: 683
  ident: bb0055
  article-title: A cardiac microRNA governs systemic energy homeostasis by regulation of MED13
  publication-title: Cell
  contributor:
    fullname: Olson
– volume: 4
  start-page: 2019
  year: 2013
  ident: bb0140
  article-title: Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
  publication-title: Nat. Commun.
  contributor:
    fullname: van Bilsen
– volume: 583
  start-page: 3230
  year: 2009
  end-page: 3234
  ident: bb0215
  article-title: Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
  publication-title: FEBS Lett.
  contributor:
    fullname: Li
– volume: 276
  start-page: 28430
  year: 2001
  end-page: 28435
  ident: bb0410
  article-title: Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Draznin
– volume: 23
  start-page: 427
  year: 2016
  end-page: 440
  ident: bb0390
  article-title: A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects
  publication-title: Cell Metab.
  contributor:
    fullname: Owen
– volume: 154
  start-page: 698
  year: 2013
  end-page: 708
  ident: bb0230
  article-title: SUMO-1 regulates body weight and adipogenesis via PPARgamma in male and female mice
  publication-title: Endocrinology
  contributor:
    fullname: Janne
– volume: 150
  start-page: 4931
  year: 2009
  end-page: 4940
  ident: bb0400
  article-title: Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
  publication-title: Endocrinology
  contributor:
    fullname: Maratos-Flier
– volume: 154
  start-page: 1055
  year: 2013
  end-page: 1068
  ident: bb0310
  article-title: Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-kappaB signaling pathway
  publication-title: Endocrinology
  contributor:
    fullname: Sun
– volume: 96
  start-page: 3242
  year: 2011
  end-page: 3249
  ident: bb0295
  article-title: Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
  publication-title: J. Clin. Endocrinol. Metab.
  contributor:
    fullname: Levy
– volume: 3
  start-page: 81
  year: 2014
  end-page: 83
  ident: bb0425
  article-title: SUMO wars
  publication-title: Mol Metab
  contributor:
    fullname: Maratos-Flier
– volume: 286
  start-page: 12983
  year: 2011
  end-page: 12990
  ident: bb0110
  article-title: Thermogenic activation induces FGF21 expression and release in brown adipose tissue
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Villarroya
– volume: 55
  start-page: 2229
  year: 2014
  end-page: 2241
  ident: bb0205
  article-title: Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
  publication-title: J. Lipid Res.
  contributor:
    fullname: Eder
– volume: 53
  start-page: 2070
  year: 2009
  end-page: 2077
  ident: bb0030
  article-title: Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure
  publication-title: J. Am. Coll. Cardiol.
  contributor:
    fullname: Maeda
– volume: 157
  start-page: 1467
  year: 2016
  end-page: 1480
  ident: bb0385
  article-title: Overexpression of beta-klotho in adipose tissue sensitizes male mice to endogenous FGF21 and provides protection from diet-induced obesity
  publication-title: Endocrinology
  contributor:
    fullname: Adams
– volume: 77
  start-page: 289
  year: 2008
  end-page: 312
  ident: bb0065
  article-title: Fat and beyond: the diverse biology of PPARgamma
  publication-title: Annu. Rev. Biochem.
  contributor:
    fullname: Spiegelman
– volume: 291
  start-page: E755
  year: 2006
  end-page: E760
  ident: bb0275
  article-title: Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  contributor:
    fullname: Goldberg
– volume: 23
  start-page: 439
  year: 2009
  end-page: 451
  ident: bb0060
  article-title: The human CDK8 subcomplex is a molecular switch that controls mediator coactivator function
  publication-title: Genes Dev.
  contributor:
    fullname: Taatjes
– volume: 508
  start-page: 949
  year: 1998
  end-page: 953
  ident: bb0325
  article-title: Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
  publication-title: J. Physiol.
  contributor:
    fullname: Pedersen
– volume: 2
  start-page: 31
  year: 2012
  end-page: 37
  ident: bb0370
  article-title: The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
  publication-title: Molecular metabolism
  contributor:
    fullname: Kharitonenkov
– volume: 16
  start-page: 387
  year: 2012
  end-page: 393
  ident: bb0150
  article-title: betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
  publication-title: Cell Metab.
  contributor:
    fullname: Kliewer
– volume: 2
  start-page: 205
  year: 2013
  end-page: 214
  ident: bb0420
  article-title: Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
  publication-title: Mol Metab
  contributor:
    fullname: Kharitonenkov
– volume: 24
  start-page: 2050
  year: 2010
  end-page: 2064
  ident: bb0115
  article-title: Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse
  publication-title: Mol. Endocrinol.
  contributor:
    fullname: Mangelsdorf
– volume: 149
  start-page: 6018
  year: 2008
  end-page: 6027
  ident: bb0190
  article-title: Fibroblast growth factor 21 corrects obesity in mice
  publication-title: Endocrinology
  contributor:
    fullname: Kharitonenkov
– volume: 148
  start-page: 556
  year: 2012
  end-page: 567
  ident: bb0220
  article-title: Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
  publication-title: Cell
  contributor:
    fullname: Kliewer
– volume: 26
  start-page: 2738
  year: 2019
  end-page: 2752 e2734
  ident: bb0180
  article-title: Exercise alleviates obesity-induced metabolic dysfunction via enhancing FGF21 sensitivity in adipose tissues
  publication-title: Cell Rep.
  contributor:
    fullname: Xu
– volume: 14
  start-page: 656
  year: 2008
  end-page: 666
  ident: bb0240
  article-title: SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta
  publication-title: Nat. Med.
  contributor:
    fullname: Nagai
– volume: 74
  start-page: 403
  year: 2008
  end-page: 412
  ident: bb0100
  article-title: Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Wong
– volume: 17
  start-page: 779
  year: 2013
  end-page: 789
  ident: bb0375
  article-title: Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
  publication-title: Cell Metab.
  contributor:
    fullname: Xu
– volume: 115
  start-page: 1627
  year: 2005
  end-page: 1635
  ident: bb0185
  article-title: FGF-21 as a novel metabolic regulator
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Owens
– volume: 10
  year: 2017
  ident: bb0280
  article-title: Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance
  publication-title: Sci. Signal.
  contributor:
    fullname: Collins
– volume: 26
  start-page: 271
  year: 2012
  end-page: 281
  ident: bb0170
  article-title: FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
  publication-title: Genes Dev.
  contributor:
    fullname: Maratos-Flier
– volume: 122
  start-page: 1022
  year: 2012
  end-page: 1036
  ident: bb0035
  article-title: Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Collins
– volume: 54
  start-page: 2514
  year: 2005
  end-page: 2524
  ident: bb0350
  article-title: Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver
  publication-title: Diabetes
  contributor:
    fullname: Cline
– volume: 28
  start-page: 188
  year: 2008
  end-page: 200
  ident: bb0105
  article-title: Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Farmer
– volume: 286
  start-page: 36331
  year: 2011
  end-page: 36339
  ident: bb0260
  article-title: Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Goldberg
– volume: 36
  start-page: 2126
  year: 2017
  end-page: 2145
  ident: bb0305
  article-title: OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance
  publication-title: EMBO J.
  contributor:
    fullname: Seei
– volume: 582
  start-page: 1725
  year: 2008
  end-page: 1730
  ident: bb0210
  article-title: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity
  publication-title: FEBS Lett.
  contributor:
    fullname: Ryden
– volume: 118
  start-page: 1736
  year: 2016
  end-page: 1751
  ident: bb0005
  article-title: Lipid use and misuse by the heart
  publication-title: Circ. Res.
  contributor:
    fullname: Goldberg
– volume: 279
  start-page: 25050
  year: 2004
  end-page: 25057
  ident: bb0010
  article-title: Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Goldberg
– volume: 19
  start-page: 83
  year: 2013
  end-page: 92
  ident: bb0335
  article-title: Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
  publication-title: Nat. Med.
  contributor:
    fullname: Kim
– volume: 111
  start-page: 9491
  year: 2014
  end-page: 9496
  ident: bb0340
  article-title: Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Olson
– volume: 4
  year: 2015
  ident: bb0045
  article-title: Identification of a novel heart-liver axis: matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate lipid metabolism and inflammation in the liver
  publication-title: J. Am. Heart Assoc.
  contributor:
    fullname: Lambeau
– volume: 118
  start-page: 241
  year: 2016
  end-page: 253
  ident: bb0235
  article-title: Cardiac myocyte KLF5 regulates Ppara expression and cardiac function
  publication-title: Circ. Res.
  contributor:
    fullname: Aifantis
– volume: 6
  start-page: 1610
  year: 2014
  end-page: 1621
  ident: bb0050
  article-title: MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver
  publication-title: EMBO Mol. Med.
  contributor:
    fullname: Scherer
– volume: 20
  start-page: 649
  year: 1999
  end-page: 688
  ident: bb0080
  article-title: Peroxisome proliferator-activated receptors: nuclear control of metabolism
  publication-title: Endocr. Rev.
  contributor:
    fullname: Wahli
– volume: 5
  start-page: 426
  year: 2007
  end-page: 437
  ident: bb0165
  article-title: Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
  publication-title: Cell Metab.
  contributor:
    fullname: Maratos-Flier
– volume: 14
  start-page: 1345
  year: 2000
  end-page: 1351
  ident: bb0020
  article-title: Natriuretic peptides: a new lipolytic pathway in human adipocytes
  publication-title: FASEB J.
  contributor:
    fullname: Galitzky
– volume: 58
  start-page: 250
  year: 2009
  end-page: 259
  ident: bb0395
  article-title: Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
  publication-title: Diabetes
  contributor:
    fullname: Lindberg
– volume: 5
  start-page: 415
  year: 2007
  end-page: 425
  ident: bb0160
  article-title: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
  publication-title: Cell Metab.
  contributor:
    fullname: Esser
– volume: 210
  start-page: 1
  year: 2007
  end-page: 6
  ident: bb0415
  article-title: Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling
  publication-title: J. Cell. Physiol.
  contributor:
    fullname: Kharitonenkov
– volume: 21
  start-page: 1497
  year: 2015
  end-page: 1501
  ident: bb0330
  article-title: Microbiota depletion promotes browning of white adipose tissue and reduces obesity
  publication-title: Nat. Med.
  contributor:
    fullname: Germain
– volume: 150
  start-page: 4931
  year: 2009
  ident: 10.1016/j.bbadis.2019.04.010_bb0400
  article-title: Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
  publication-title: Endocrinology
  doi: 10.1210/en.2009-0532
  contributor:
    fullname: Badman
– volume: 17
  start-page: 790
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0380
  article-title: An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.03.019
  contributor:
    fullname: Holland
– volume: 17
  start-page: 779
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0375
  article-title: Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.04.005
  contributor:
    fullname: Lin
– volume: 24
  start-page: 2050
  year: 2010
  ident: 10.1016/j.bbadis.2019.04.010_bb0115
  article-title: Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2010-0142
  contributor:
    fullname: Fon Tacer
– volume: 96
  start-page: 3242
  year: 2011
  ident: 10.1016/j.bbadis.2019.04.010_bb0295
  article-title: Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2011-1182
  contributor:
    fullname: Khan
– volume: 26
  start-page: 2738
  year: 2019
  ident: 10.1016/j.bbadis.2019.04.010_bb0180
  article-title: Exercise alleviates obesity-induced metabolic dysfunction via enhancing FGF21 sensitivity in adipose tissues
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.02.014
  contributor:
    fullname: Geng
– volume: 10
  year: 2017
  ident: 10.1016/j.bbadis.2019.04.010_bb0280
  article-title: Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aam6870
  contributor:
    fullname: Wu
– volume: 3
  start-page: R31
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0015
  article-title: The heart as an endocrine organ
  publication-title: Endocr Connect
  doi: 10.1530/EC-14-0012
  contributor:
    fullname: Ogawa
– volume: 19
  start-page: 458
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0360
  article-title: Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.02.004
  contributor:
    fullname: Dogan
– volume: 54
  start-page: 2514
  year: 2005
  ident: 10.1016/j.bbadis.2019.04.010_bb0350
  article-title: Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver
  publication-title: Diabetes
  doi: 10.2337/diabetes.54.9.2514
  contributor:
    fullname: Park
– volume: 276
  start-page: 28430
  year: 2001
  ident: 10.1016/j.bbadis.2019.04.010_bb0410
  article-title: Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M103382200
  contributor:
    fullname: Klemm
– volume: 6
  start-page: 1610
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0050
  article-title: MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201404218
  contributor:
    fullname: Baskin
– volume: 63
  start-page: 4057
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0355
  article-title: Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding
  publication-title: Diabetes
  doi: 10.2337/db14-0595
  contributor:
    fullname: Markan
– volume: 122
  start-page: 1022
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0035
  article-title: Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI59701
  contributor:
    fullname: Bordicchia
– volume: 508
  start-page: 949
  year: 1998
  ident: 10.1016/j.bbadis.2019.04.010_bb0325
  article-title: Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
  publication-title: J. Physiol.
  doi: 10.1111/j.1469-7793.1998.949bp.x
  contributor:
    fullname: Ostrowski
– volume: 18
  start-page: 333
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0195
  article-title: The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.08.005
  contributor:
    fullname: Gaich
– volume: 109
  start-page: 594
  year: 2004
  ident: 10.1016/j.bbadis.2019.04.010_bb0290
  article-title: Impact of obesity on plasma natriuretic peptide levels
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000112582.16683.EA
  contributor:
    fullname: Wang
– volume: 358
  start-page: 771
  year: 1992
  ident: 10.1016/j.bbadis.2019.04.010_bb0085
  article-title: Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
  publication-title: Nature
  doi: 10.1038/358771a0
  contributor:
    fullname: Kliewer
– volume: 149
  start-page: 671
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0055
  article-title: A cardiac microRNA governs systemic energy homeostasis by regulation of MED13
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.029
  contributor:
    fullname: Grueter
– volume: 28
  start-page: 3702
  year: 2009
  ident: 10.1016/j.bbadis.2019.04.010_bb0265
  article-title: Kruppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1
  publication-title: Oncogene
  doi: 10.1038/onc.2009.235
  contributor:
    fullname: Zheng
– volume: 118
  start-page: 1736
  year: 2016
  ident: 10.1016/j.bbadis.2019.04.010_bb0005
  article-title: Lipid use and misuse by the heart
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.306842
  contributor:
    fullname: Schulze
– volume: 154
  start-page: 698
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0230
  article-title: SUMO-1 regulates body weight and adipogenesis via PPARgamma in male and female mice
  publication-title: Endocrinology
  doi: 10.1210/en.2012-1846
  contributor:
    fullname: Mikkonen
– volume: 21
  start-page: 1497
  year: 2015
  ident: 10.1016/j.bbadis.2019.04.010_bb0330
  article-title: Microbiota depletion promotes browning of white adipose tissue and reduces obesity
  publication-title: Nat. Med.
  doi: 10.1038/nm.3994
  contributor:
    fullname: Suarez-Zamorano
– volume: 23
  start-page: 427
  year: 2016
  ident: 10.1016/j.bbadis.2019.04.010_bb0390
  article-title: A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.02.001
  contributor:
    fullname: Talukdar
– volume: 210
  start-page: 1
  year: 2007
  ident: 10.1016/j.bbadis.2019.04.010_bb0415
  article-title: Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.20847
  contributor:
    fullname: Moyers
– volume: 13
  start-page: 274
  year: 2016
  ident: 10.1016/j.bbadis.2019.04.010_bb0200
  article-title: Ectopic adipose tissue storage in the left and the right renal sinus is asymmetric and associated with serum kidney injury molecule-1 and fibroblast growth factor-21 levels increase
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2016.10.020
  contributor:
    fullname: Krievina
– volume: 23
  start-page: 24
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0125
  article-title: Elevated FGF21 secretion, PGC-1alpha and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddt393
  contributor:
    fullname: Crooks
– volume: 433
  start-page: 155
  year: 2011
  ident: 10.1016/j.bbadis.2019.04.010_bb0225
  article-title: SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor gamma in C2C12 myotubes
  publication-title: Biochem. J.
  doi: 10.1042/BJ20100749
  contributor:
    fullname: Chung
– volume: 16
  start-page: 387
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0150
  article-title: betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.08.002
  contributor:
    fullname: Ding
– volume: 1492
  start-page: 203
  year: 2000
  ident: 10.1016/j.bbadis.2019.04.010_bb0095
  article-title: Identification of a novel FGF, FGF-21, preferentially expressed in the liver
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/S0167-4781(00)00067-1
  contributor:
    fullname: Nishimura
– volume: 9
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0145
  article-title: Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0087102
  contributor:
    fullname: Patel
– volume: 90
  start-page: 3622
  year: 2005
  ident: 10.1016/j.bbadis.2019.04.010_bb0025
  article-title: Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2004-1953
  contributor:
    fullname: Birkenfeld
– volume: 219
  start-page: 362
  year: 2017
  ident: 10.1016/j.bbadis.2019.04.010_bb0320
  article-title: Crosstalk between adipokines and myokines in fat browning
  publication-title: Acta Physiol. (Oxford)
  doi: 10.1111/apha.12686
  contributor:
    fullname: Rodriguez
– volume: 95
  start-page: 2979
  year: 1998
  ident: 10.1016/j.bbadis.2019.04.010_bb0245
  article-title: HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.95.6.2979
  contributor:
    fullname: Claycomb
– volume: 53
  start-page: 2070
  year: 2009
  ident: 10.1016/j.bbadis.2019.04.010_bb0030
  article-title: Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2009.02.038
  contributor:
    fullname: Tsukamoto
– volume: 28
  start-page: 188
  year: 2008
  ident: 10.1016/j.bbadis.2019.04.010_bb0105
  article-title: Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00992-07
  contributor:
    fullname: Wang
– volume: 583
  start-page: 3230
  year: 2009
  ident: 10.1016/j.bbadis.2019.04.010_bb0215
  article-title: Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2009.09.012
  contributor:
    fullname: Li
– volume: 55
  start-page: 2229
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0205
  article-title: Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M044784
  contributor:
    fullname: Brahma
– volume: 26
  start-page: 271
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0170
  article-title: FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
  publication-title: Genes Dev.
  doi: 10.1101/gad.177857.111
  contributor:
    fullname: Fisher
– volume: 25
  start-page: 935
  year: 2017
  ident: 10.1016/j.bbadis.2019.04.010_bb0365
  article-title: FGF21 regulates metabolism through adipose-dependent and -independent mechanisms
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2017.03.005
  contributor:
    fullname: BonDurant
– volume: 36
  start-page: 2126
  year: 2017
  ident: 10.1016/j.bbadis.2019.04.010_bb0305
  article-title: OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance
  publication-title: EMBO J.
  doi: 10.15252/embj.201696179
  contributor:
    fullname: Pereira
– volume: 58
  start-page: 250
  year: 2009
  ident: 10.1016/j.bbadis.2019.04.010_bb0395
  article-title: Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
  publication-title: Diabetes
  doi: 10.2337/db08-0392
  contributor:
    fullname: Xu
– ident: 10.1016/j.bbadis.2019.04.010_bb0250
  doi: 10.1161/CIRCULATIONAHA.111.044255
– volume: 5
  start-page: 426
  year: 2007
  ident: 10.1016/j.bbadis.2019.04.010_bb0165
  article-title: Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2007.05.002
  contributor:
    fullname: Badman
– volume: 26
  start-page: 709
  year: 2017
  ident: 10.1016/j.bbadis.2019.04.010_bb0405
  article-title: FGF19, FGF21, and an FGFR1/beta-klotho-activating antibody act on the nervous system to regulate body weight and glycemia
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2017.09.005
  contributor:
    fullname: Lan
– volume: 2
  start-page: 205
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0420
  article-title: Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
  publication-title: Mol Metab
  doi: 10.1016/j.molmet.2013.05.005
  contributor:
    fullname: Adams
– volume: 20
  start-page: 649
  year: 1999
  ident: 10.1016/j.bbadis.2019.04.010_bb0080
  article-title: Peroxisome proliferator-activated receptors: nuclear control of metabolism
  publication-title: Endocr. Rev.
  contributor:
    fullname: Desvergne
– volume: 291
  start-page: E755
  year: 2006
  ident: 10.1016/j.bbadis.2019.04.010_bb0275
  article-title: Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00111.2006
  contributor:
    fullname: Noh
– volume: 4
  start-page: 2019
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0140
  article-title: Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3019
  contributor:
    fullname: Planavila
– volume: 3
  start-page: 81
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0425
  article-title: SUMO wars
  publication-title: Mol Metab
  doi: 10.1016/j.molmet.2013.12.002
  contributor:
    fullname: Fisher
– volume: 286
  start-page: 12983
  year: 2011
  ident: 10.1016/j.bbadis.2019.04.010_bb0110
  article-title: Thermogenic activation induces FGF21 expression and release in brown adipose tissue
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.215889
  contributor:
    fullname: Hondares
– volume: 19
  start-page: 83
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0335
  article-title: Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
  publication-title: Nat. Med.
  doi: 10.1038/nm.3014
  contributor:
    fullname: Kim
– volume: 59
  start-page: 2781
  year: 2010
  ident: 10.1016/j.bbadis.2019.04.010_bb0175
  article-title: Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
  publication-title: Diabetes
  doi: 10.2337/db10-0193
  contributor:
    fullname: Fisher
– volume: 11
  year: 2016
  ident: 10.1016/j.bbadis.2019.04.010_bb0130
  article-title: Fibroblast growth factor 21 (FGF21) protects against high fat diet induced inflammation and islet hyperplasia in pancreas
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0148252
  contributor:
    fullname: Singhal
– volume: 287
  start-page: 2558
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0255
  article-title: Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.316760
  contributor:
    fullname: Jurczak
– volume: 4
  year: 2015
  ident: 10.1016/j.bbadis.2019.04.010_bb0045
  article-title: Identification of a novel heart-liver axis: matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate lipid metabolism and inflammation in the liver
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.115.002553
  contributor:
    fullname: Hernandez-Anzaldo
– volume: 13
  year: 2017
  ident: 10.1016/j.bbadis.2019.04.010_bb0345
  article-title: Cardiomyocyte regulation of systemic lipid metabolism by the apolipoprotein B-containing lipoproteins in drosophila
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1006555
  contributor:
    fullname: Lee
– volume: 148
  start-page: 556
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0220
  article-title: Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.062
  contributor:
    fullname: Dutchak
– volume: 3
  year: 2008
  ident: 10.1016/j.bbadis.2019.04.010_bb0300
  article-title: Fetuin-a induces cytokine expression and suppresses adiponectin production
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0001765
  contributor:
    fullname: Hennige
– volume: 74
  start-page: 403
  year: 2008
  ident: 10.1016/j.bbadis.2019.04.010_bb0100
  article-title: Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.108.044826
  contributor:
    fullname: Muise
– volume: 279
  start-page: 25050
  year: 2004
  ident: 10.1016/j.bbadis.2019.04.010_bb0010
  article-title: Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M401028200
  contributor:
    fullname: Augustus
– volume: 48
  start-page: 699
  year: 1999
  ident: 10.1016/j.bbadis.2019.04.010_bb0070
  article-title: Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes
  publication-title: Diabetes
  doi: 10.2337/diabetes.48.4.699
  contributor:
    fullname: Rieusset
– volume: 14
  start-page: 1345
  year: 2000
  ident: 10.1016/j.bbadis.2019.04.010_bb0020
  article-title: Natriuretic peptides: a new lipolytic pathway in human adipocytes
  publication-title: FASEB J.
  doi: 10.1096/fasebj.14.10.1345
  contributor:
    fullname: Sengenes
– volume: 5
  start-page: 415
  year: 2007
  ident: 10.1016/j.bbadis.2019.04.010_bb0160
  article-title: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2007.05.003
  contributor:
    fullname: Inagaki
– volume: 118
  start-page: 241
  year: 2016
  ident: 10.1016/j.bbadis.2019.04.010_bb0235
  article-title: Cardiac myocyte KLF5 regulates Ppara expression and cardiac function
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.115.306383
  contributor:
    fullname: Drosatos
– volume: 153
  start-page: 349
  year: 1998
  ident: 10.1016/j.bbadis.2019.04.010_bb0075
  article-title: Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse
  publication-title: Am. J. Pathol.
  doi: 10.1016/S0002-9440(10)65577-0
  contributor:
    fullname: Jain
– volume: 2
  start-page: 31
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0370
  article-title: The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
  publication-title: Molecular metabolism
  doi: 10.1016/j.molmet.2012.08.007
  contributor:
    fullname: Adams
– volume: 6
  start-page: 482
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0040
  article-title: Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy
  publication-title: EMBO Mol. Med.
  doi: 10.1002/emmm.201302852
  contributor:
    fullname: Magida
– volume: 77
  start-page: 289
  year: 2008
  ident: 10.1016/j.bbadis.2019.04.010_bb0065
  article-title: Fat and beyond: the diverse biology of PPARgamma
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.77.061307.091829
  contributor:
    fullname: Tontonoz
– volume: 582
  start-page: 3805
  year: 2008
  ident: 10.1016/j.bbadis.2019.04.010_bb0120
  article-title: FGF21 is an Akt-regulated myokine
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2008.10.021
  contributor:
    fullname: Izumiya
– volume: 154
  start-page: 1055
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0310
  article-title: Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-kappaB signaling pathway
  publication-title: Endocrinology
  doi: 10.1210/en.2012-2144
  contributor:
    fullname: Zhou
– volume: 25
  start-page: 472
  year: 2017
  ident: 10.1016/j.bbadis.2019.04.010_bb0135
  article-title: FGF21 is an exocrine pancreas secretagogue
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.12.004
  contributor:
    fullname: Coate
– volume: 286
  start-page: 36331
  year: 2011
  ident: 10.1016/j.bbadis.2019.04.010_bb0260
  article-title: Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.272146
  contributor:
    fullname: Drosatos
– volume: 115
  start-page: 1627
  year: 2005
  ident: 10.1016/j.bbadis.2019.04.010_bb0185
  article-title: FGF-21 as a novel metabolic regulator
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI23606
  contributor:
    fullname: Kharitonenkov
– volume: 157
  start-page: 1467
  year: 2016
  ident: 10.1016/j.bbadis.2019.04.010_bb0385
  article-title: Overexpression of beta-klotho in adipose tissue sensitizes male mice to endogenous FGF21 and provides protection from diet-induced obesity
  publication-title: Endocrinology
  doi: 10.1210/en.2015-1722
  contributor:
    fullname: Samms
– volume: 74
  start-page: 1765
  year: 2017
  ident: 10.1016/j.bbadis.2019.04.010_bb0315
  article-title: Inter-organ regulation of adipose tissue browning. Cellular and molecular life sciences
  publication-title: CMLS
  doi: 10.1007/s00018-016-2420-x
  contributor:
    fullname: Wang
– volume: 582
  start-page: 1725
  year: 2008
  ident: 10.1016/j.bbadis.2019.04.010_bb0210
  article-title: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2008.04.038
  contributor:
    fullname: Arner
– volume: 7
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0155
  article-title: FGF21 requires betaklotho to act in vivo
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0049977
  contributor:
    fullname: Adams
– volume: 112
  start-page: 2163
  year: 2005
  ident: 10.1016/j.bbadis.2019.04.010_bb0285
  article-title: Impact of body mass and body composition on circulating levels of natriuretic peptides: results from the Dallas Heart Study
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.555573
  contributor:
    fullname: Das
– volume: 6
  start-page: 550
  year: 2013
  ident: 10.1016/j.bbadis.2019.04.010_bb0270
  article-title: Peroxisome proliferator-activated receptor-gamma activation prevents sepsis-related cardiac dysfunction and mortality in mice
  publication-title: Circ. Heart Fail.
  doi: 10.1161/CIRCHEARTFAILURE.112.000177
  contributor:
    fullname: Drosatos
– volume: 1822
  start-page: 1090
  year: 2012
  ident: 10.1016/j.bbadis.2019.04.010_bb0090
  article-title: Controlling a master switch of adipocyte development and insulin sensitivity: covalent modifications of PPARgamma
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbadis.2012.03.014
  contributor:
    fullname: Floyd
– volume: 14
  start-page: 656
  year: 2008
  ident: 10.1016/j.bbadis.2019.04.010_bb0240
  article-title: SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta
  publication-title: Nat. Med.
  doi: 10.1038/nm1756
  contributor:
    fullname: Oishi
– volume: 23
  start-page: 439
  year: 2009
  ident: 10.1016/j.bbadis.2019.04.010_bb0060
  article-title: The human CDK8 subcomplex is a molecular switch that controls mediator coactivator function
  publication-title: Genes Dev.
  doi: 10.1101/gad.1767009
  contributor:
    fullname: Knuesel
– volume: 149
  start-page: 6018
  year: 2008
  ident: 10.1016/j.bbadis.2019.04.010_bb0190
  article-title: Fibroblast growth factor 21 corrects obesity in mice
  publication-title: Endocrinology
  doi: 10.1210/en.2008-0816
  contributor:
    fullname: Coskun
– volume: 111
  start-page: 9491
  year: 2014
  ident: 10.1016/j.bbadis.2019.04.010_bb0340
  article-title: Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1409427111
  contributor:
    fullname: Lee
SSID ssj0000670
Score 2.3980916
Snippet Cardiac metabolism affects systemic energetic balance. Previously, we showed that Krüppel-like factor (KLF)-5 regulates cardiomyocyte PPARα and fatty acid...
SourceID pubmedcentral
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 2125
SubjectTerms Adipose Tissue, White - metabolism
Adipose Tissue, White - pathology
Animals
Body Weight
Diet, High-Fat
Female
FGF21
Fibroblast Growth Factors - blood
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - metabolism
Heart
High fat diet
Humans
Kruppel-Like Transcription Factors - genetics
Kruppel-Like Transcription Factors - metabolism
Krüppel-like factor
Leptin - blood
Male
Mediator Complex - genetics
Mediator Complex - metabolism
Mice
Mice, Knockout
MicroRNAs - metabolism
Myocardium - metabolism
Myocytes, Cardiac - cytology
Myocytes, Cardiac - metabolism
Obesity
Obesity - etiology
Signal Transduction
Title Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21
URI https://dx.doi.org/10.1016/j.bbadis.2019.04.010
https://www.ncbi.nlm.nih.gov/pubmed/31029826
https://pubmed.ncbi.nlm.nih.gov/PMC6614009
Volume 1865
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