Integrating Phylogenetics With Intron Positions Illuminates the Origin of the Complex Spliceosome

• Published in: Molecular biology and evolution Vol. 40; no. 1
• Main Authors: Vosseberg, Julian, Stolker, Daan, von der Dunk, Samuel H A, Snel, Berend
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 04.01.2023
• Subjects: Discoveries; Eukaryota - genetics; Evolution, Molecular; Genes; Genomics; Introns; Phylogeny; Proteins; RNA; RNA Splicing; Spliceosomes - genetics; eukaryogenesis; introns; spliceosome

Abstract Eukaryotic genes are characterized by the presence of introns that are removed from pre-mRNA by a spliceosome. This ribonucleoprotein complex is comprised of multiple RNA molecules and over a hundred proteins, which makes it one of the most complex molecular machines that originated during...