Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses - Alameh, Mohamad-Gabriel; Tombácz, István; Bettini, Emily; Lederer, Katlyn; Ndeupen, Sonia; Sittplangkoon, Chutamath; Wilmore, Joel R.; Gaudette, Brian T.; Soliman, Ousamah Y.; Pine, Matthew; Hicks, Philip; Manzoni, Tomaz B.; et al. (Immunity (Cambridge, Mass.), 2021)
Keywords: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; adjuvant; Adjuvants, Immunologic; Animals; B-Lymphocytes - immunology; COVID-19 - immunology; COVID-19 Vaccines - immunology; Germinal Center - immunology; germinal centers; HEK293 Cells; Humans; IL-6; Immunity, Humoral; influenza virus; Interleukin-6 - genetics; Interleukin-6 - metabolism; lipid nanoparticle; Liposomes - administration & dosage; Mice; Mice, Inbred BALB C; mRNA Vaccines - genetics; mRNA Vaccines - immunology; Nanoparticles - administration & dosage; Protein Subunits - genetics; SARS-CoV-2; SARS-CoV-2 - physiology; T-Lymphocytes, Helper-Inducer - immunology; Tfh cell; vaccine; vaccine; lipid nanoparticle; SARS-CoV-2; adjuvant; influenza virus; germinal centers; Tfh cell; IL-6