Adverse Effects of Mammalian Target of Rapamycin Inhibitors During the Postoperative Period After Cardiac Transplantation

• Published in: Transplantation proceedings Vol. 40; no. 9; pp. 3027 - 3030
• Main Authors: Bouzas-Mosquera, A, Crespo-Leiro, M.G, Paniagua, M.J, Naya, C, Grille, Z, Marzoa, R, Barge-Caballero, E, Estévez-Cid, F, Álvarez-García, N, Cuenca, J.J, Castro-Beiras, A
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.11.2008; Elsevier
• Subjects: Adult; Biological and medical sciences; Diabetes Mellitus - epidemiology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Heart Transplantation - adverse effects; Heart Transplantation - immunology; Humans; Immunosuppressive Agents - therapeutic use; Male; Medical sciences; Middle Aged; Patient Selection; Pericardial Effusion - epidemiology; Pleural Effusion - epidemiology; Postoperative Period; Protein Kinases - therapeutic use; Retrospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; TOR Serine-Threonine Kinases; Heart; Postoperative; Toxicity; Period; Transplantation; Homotransplantation; Medicine; Treatment; Surgery; Mammalian target of rapamycin; Secondary effect; Graft; Inhibitor; Circulatory system

Abstract Introduction Safety of treatment with mammalian target of rapamycin inhibitors (mTORi) in the postoperative period after heart transplantation (HT) is controversial. Methods We evaluated the incidence of postoperative complications (pericardial, pleural, and surgical wound complications) am...