Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 22; pp. 5769 - 5784
• Main Authors: Travnickova, Jana, Wojciechowska, Sonia, Khamseh, Ava, Gautier, Philippe, Brown, Daniel V, Lefevre, Thomas, Brombin, Alessandro, Ewing, Ailith, Capper, Amy, Spitzer, Michaela, Dilshat, Ramile, Semple, Colin A, Mathers, Marie E, Lister, James A, Steingrimsson, Eiríkur, Voet, Thierry, Ponting, Chris P, Patton, E Elizabeth
• Format: Journal Article
• Language: English
• Published: United States 15.11.2019
• Subjects: Animals; Drug Resistance - genetics; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic - genetics; Melanocytes - pathology; Melanoma - genetics; Melanoma - pathology; Microphthalmia-Associated Transcription Factor - genetics; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; Neoplasm, Residual - genetics; Neoplasm, Residual - pathology; Neural Crest - pathology; Proto-Oncogene Proteins B-raf - genetics; Stem Cells - pathology; Transcription, Genetic - genetics; Zebrafish - genetics

The melanocyte-inducing transcription factor (MITF)-low melanoma transcriptional signature is predictive of poor outcomes for patients, but little is known about its biological significance, and animal models are lacking. Here, we used zebrafish genetic models with low activity of Mitfa (MITF-low) a...