Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness

• Published in: Journal of allergy and clinical immunology Vol. 88; no. 4; pp. 661 - 674
• Main Authors: Bradley, Brian L., Azzawi, May, Jacobson, Mikila, Assoufi, Basil, Collins, John V., Irani, Anne-marie A., Schwartz, Lawrence B., Durham, Stephen R., Jeffery, Peter K., Kay, A.Barry
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.1991; Elsevier
• Subjects: Adult; asthma; Asthma - pathology; Asthma - physiopathology; Biological and medical sciences; Biopsy; Bronchi - pathology; bronchial biopsies; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoscopy; Cell Count; Eosinophils; Female; Humans; Immunohistochemical methods; Immunological methods for diagnosis and exploration; Immunopathology; macrophages; Male; Mast Cells; Medical sciences; Middle Aged; neutrophils; Rhinitis, Allergic, Perennial - pathology; Rhinitis, Allergic, Perennial - physiopathology; T-Lymphocytes; bronchial biopsies; T-lymphocytes; macrophages; asthma; mast cells; neutrophils; Eosinophils; Human; Immunohistochemistry; Allergy; Immunopathology; Respiratory disease; Bronchus; Respiratory system; Eosinophil; Asthma; Cell population; Biopsy; T-Lymphocyte; Detection; Comparative study

Bronchial biopsy specimens were obtained by fiberoptic bronchoscopy from 21 atopic subjects with asthma, 10 atopic subjects without asthma, and 12 normal healthy control subjects. With immunohistochemical techniques and a panel of monoclonal antibodies, inflammatory cells were identified and counted...