APP/Aβ structural diversity and Alzheimer's disease pathogenesis

• Published in: Neurochemistry international Vol. 110; pp. 1 - 13
• Main Authors: Roher, Alex E., Kokjohn, Tyler A., Clarke, Steven G., Sierks, Michael R., Maarouf, Chera L., Serrano, Geidy E., Sabbagh, Marwan S., Beach, Thomas G.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2017
• Subjects: Alzheimer Disease - diagnostic imaging; Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Amyloid beta-Peptides - analysis; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - analysis; Amyloid beta-Protein Precursor - chemistry; Amyloid beta-Protein Precursor - metabolism; Animals; Brain - metabolism; Brain - pathology; Humans; Plaque, Amyloid - complications; Plaque, Amyloid - diagnostic imaging; Plaque, Amyloid - metabolism

The amyloid cascade hypothesis of Alzheimer's disease (AD) proposes amyloid- β (Aβ) is a chief pathological element of dementia. AD therapies have targeted monomeric and oligomeric Aβ 1–40 and 1–42 peptides. However, alternative APP proteolytic processing produces a complex roster of Aβ species...