Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

• Published in: Cell reports (Cambridge) Vol. 38; no. 11; p. 110509
• Main Authors: Hu, Song-Hua, He, Xia-Di, Nie, Ji, Hou, Jun-Li, Wu, Jiang, Liu, Xiao-Yan, Wei, Yun, Tang, Hui-Ru, Sun, Wen-Xing, Zhou, Shu-Xian, Yuan, Yi-Yuan, An, Yan-Peng, Yan, Guo-Quan, Lin, Yan, Lin, Peng-Cheng, Zhao, Jean J., Ye, Ming-Liang, Zhao, Jian-Yuan, Xu, Wei, Zhao, Shi-Min
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2022
• Subjects: Acylation; Akt signaling; Animals; DHA/EPA; Docosahexaenoic Acids - metabolism; Docosahexaenoic Acids - pharmacology; Eicosapentaenoic Acid - metabolism; Eicosapentaenoic Acid - pharmacology; Fatty Acids, Unsaturated; fatty acylation; Glucose - metabolism; Mice; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Tryptophan - metabolism; Akt signaling; fatty acylation; DHA/EPA

Protein fatty acylation regulates numerous cell signaling pathways. Polyunsaturated fatty acids (PUFAs) exert a plethora of physiological effects, including cell signaling regulation, with underlying mechanisms to be fully understood. Herein, we report that docosahexaenoic acid (DHA) and eicosapenta...