Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: Evidence for synergism between serotonergic and noradrenergic reuptake inhibition

• Published in: Neuropharmacology Vol. 51; no. 7; pp. 1172 - 1180
• Main Authors: Jones, Carrie K., Eastwood, Brian J., Need, Anne B., Shannon, Harlan E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2006
• Subjects: Adrenergic Uptake Inhibitors - pharmacology; Adrenergic Uptake Inhibitors - therapeutic use; Analgesics, Non-Narcotic - pharmacology; Analgesics, Non-Narcotic - therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Brain Chemistry - drug effects; Carrageenan - toxicity; Carrageenan test; Cyclohexanols - pharmacology; Cyclohexanols - therapeutic use; Desipramine - pharmacology; Desipramine - therapeutic use; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Duloxetine; Duloxetine Hydrochloride; Edema - chemically induced; Edema - drug therapy; Fluoxetine - analogs & derivatives; Fluoxetine - analysis; Fluoxetine - pharmacology; Fluoxetine - therapeutic use; Hot Temperature - adverse effects; Hyperalgesia - chemically induced; Hyperalgesia - drug therapy; Hyperalgesia - physiopathology; Male; Mixed serotonergic–noradrenergic reuptake inhibition; Noradrenergic reuptake inhibition; Norepinephrine - physiology; Paroxetine - pharmacology; Paroxetine - therapeutic use; Persistent pain; Pressure - adverse effects; Rats; Rats, Sprague-Dawley; Serotonergic reuptake inhibition; Serotonin - physiology; Serotonin Uptake Inhibitors - pharmacology; Serotonin Uptake Inhibitors - therapeutic use; Sertraline - pharmacology; Sertraline - therapeutic use; Thiophenes - pharmacology; Thiophenes - therapeutic use; Venlafaxine Hydrochloride; Mixed serotonergic–noradrenergic reuptake inhibition; Duloxetine; Persistent pain; Noradrenergic reuptake inhibition; Carrageenan test; Serotonergic reuptake inhibition

The efficacy of antidepressant drugs with serotonergic, noradrenergic, or dual reuptake inhibition was evaluated in reversing carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats. Duloxetine (1–30 mg/kg, i.p.), a balanced serotonergic–noradrenergic reuptake inhibitor (SNRI), was...