Chronic exposure to perfluorinated compounds: Impact on airway hyperresponsiveness and inflammation

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 307; no. 10; pp. L765 - L774
• Main Authors: Ryu, Min H, Jha, Aruni, Ojo, Oluwaseun O, Mahood, Thomas H, Basu, Sujata, Detillieux, Karen A, Nikoobakht, Neda, Wong, Charles S, Loewen, Mark, Becker, Allan B, Halayko, Andrew J
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.11.2014
• Subjects: Air Pollutants - toxicity; Alkanesulfonic Acids - toxicity; Animals; Asthma - chemically induced; Asthma - immunology; Asthma - pathology; Caprylates - toxicity; Epidemiology; Female; Fluorocarbons - toxicity; Goblet Cells - immunology; Goblet Cells - pathology; Human exposure; Indoor air quality; Interferon-gamma - immunology; Lung - immunology; Lung - pathology; Lung diseases; Maternal Exposure - adverse effects; Mice; Mice, Inbred BALB C; Perfluorocarbons; Physiology; Pollutants; Pregnancy; environmental pollutant; interferon-γ; asthma; perflurooctanesulfonic acid; perfluorooctanoic acid

Emerging epidemiological evidence reveals a link between lung disease and exposure to indoor pollutants such as perfluorinated compounds (PFCs). PFC exposure during critical developmental stages may increase asthma susceptibility. Thus, in a murine model, we tested the hypothesis that early life and...