Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway

Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO 3A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level...

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Published inColloids and surfaces, B, Biointerfaces Vol. 50; no. 2; pp. 141 - 146
Main Authors Jang, Hong Seok, Ryu, Kyu Eun, Ahn, Woong Shick, Chun, Heung Jae, Dal Park, Hyung, Park, Ki Dong, Kim, Young Ha
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2006
Subjects
Acrylate
Acrylates - chemistry
Acrylates - pharmacology
Alternative pathway
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biomaterials
Coated Materials, Biocompatible
Complement C5a - metabolism
Complement Membrane Attack Complex - metabolism
Complement Pathway, Alternative - drug effects
Copolymerization
Humans
In Vitro Techniques
Materials Testing
Molecular Structure
Poly(ethylene glycol)
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Sulfonation complement activation
Sulfonation complement activation
Copolymerization
Alternative pathway
Acrylate
Poly(ethylene glycol)
Biomaterials
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Abstract Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO 3A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO 3A chains in water phase. As continuation study, anti-complement effects of PEG-SO 3/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG-SO 3/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO 3/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO 3/OA samples markedly decreased SC5b-9 levels in plasma.
AbstractList Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO(3)A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO(3)A chains in water phase. As continuation study, anti-complement effects of PEG-SO(3)/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG-SO(3)/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO(3)/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO(3)/OA samples markedly decreased SC5b-9 levels in plasma.
Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO sub(3)A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO sub(3)A chains in water phase. As continuation study, anti-complement effects of PEG-SO sub(3)/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG- SO sub(3)/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO sub(3)/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO sub(3)/OA samples markedly decreased SC5b-9 levels in plasma.
Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO 3A/OA) copolymers were prepared as coating and/or blending materials for biomedical applications. Surfaces modified with copolymers exhibited increased anti-coagulation properties and decreased plasma adsorption level due to increased hydrophilic properties and reorientation characteristics of PEG/PEG-SO 3A chains in water phase. As continuation study, anti-complement effects of PEG-SO 3/OA copolymers were investigated in vitro, and compared with those of low-density polyethylene (LDPE) and PEG/OA. C3 activation by PEG-SO 3/OA samples was lower than that by PEG/OA samples, which was attributed to decreased surface nucleophile level of samples. PEG-SO 3/OA samples increased inhibition of Bb production, resulting in decreased C5 activation. Owing to reduced activations of C3 and C5, PEG-SO 3/OA samples markedly decreased SC5b-9 levels in plasma.
Author Park, Ki Dong
Ahn, Woong Shick
Dal Park, Hyung
Chun, Heung Jae
Ryu, Kyu Eun
Kim, Young Ha
Jang, Hong Seok
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Issue 2
Keywords Sulfonation complement activation
Copolymerization
Alternative pathway
Acrylate
Poly(ethylene glycol)
Biomaterials
Language English
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Snippet Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO 3A/OA) copolymers were prepared as coating and/or blending materials for...
Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO(3)A/OA) copolymers were prepared as coating and/or blending materials for...
Previously, novel poly(ethylene glycol) (PEG) and sulfonated PEG acrylate (PEG-SO sub(3)A/OA) copolymers were prepared as coating and/or blending materials for...
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SubjectTerms Acrylate
Acrylates - chemistry
Acrylates - pharmacology
Alternative pathway
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biomaterials
Coated Materials, Biocompatible
Complement C5a - metabolism
Complement Membrane Attack Complex - metabolism
Complement Pathway, Alternative - drug effects
Copolymerization
Humans
In Vitro Techniques
Materials Testing
Molecular Structure
Poly(ethylene glycol)
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Sulfonation complement activation
Title Complement activation by sulfonated poly(ethylene glycol)-acrylate copolymers through alternative pathway
URI https://dx.doi.org/10.1016/j.colsurfb.2006.03.024
https://www.ncbi.nlm.nih.gov/pubmed/16797170
https://search.proquest.com/docview/19451576
https://search.proquest.com/docview/68603419
Volume 50
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