Single-sample landscape entropy reveals the imminent phase transition during disease progression

• Published in: Bioinformatics Vol. 36; no. 5; pp. 1522 - 1532
• Main Authors: Liu, Rui, Chen, Pei, Chen, Luonan
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2020

Abstract Motivation The time evolution or dynamic change of many biological systems during disease progression is not always smooth but occasionally abrupt, that is, there is a tipping point during such a process at which the system state shifts from the normal state to a disease state. It is challe...