Physical crosslinking of hyaluronic acid in the presence of phospholipids in an aqueous nano-environment

• Published in: Soft matter Vol. 14; no. 44; pp. 8997 - 94
• Main Authors: Be dowski, Piotr, Weber, Piotr, D dinait, Andra, Claesson, Per M, Gadomski, Adam
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 14.11.2018
• Subjects: Acids; Bond length; Bonded joints; Coarse-grained; Conformation; Cosmetology; Coupling (molecular); Couplings; Crosslinking; Dynamic couplings; Hyaluronic acid; Hydrogen bonding; Hydrogen bonds; Joint lubrication; Lipids; Lubrication; Molecular conformation; Molecular dynamics; Molecular dynamics simulations; Molecular oxygen; Organic acids; Oxygen atoms; Phospholipids; Physical crosslinking; Polymer chain conformation; Simulation; Small-world networks; Specific sites; Synovial joints

Hyaluronic acid and phospholipids are two components in the synovial joint cavity that contribute to joint lubrication synergistically. Molecular dynamics simulations were performed and hydrogen bonds in hyaluronic acid were analyzed to identify specific sites that are responsible for its physical c...