Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish

• Published in: Genes Vol. 11; no. 11; p. 1322
• Main Authors: Lai, Yu-Heng, Audira, Gilbert, Liang, Sung-Tzu, Siregar, Petrus, Suryanto, Michael Edbert, Lin, Huan-Chau, Villalobos, Omar, Villaflores, Oliver B., Hao, Erwei, Lim, Ken-Hong, Hsiao, Chung-Der
• Format: Journal Article
• Language: English
• Published: MDPI 07.11.2020
• Subjects: aggression; animal models; anxiety; circadian rhythm; cognition; color; Danio rerio; DNA methylation; DNA methyltransferase; fearfulness; fish; fish behavior; locomotion; memory; mice; mutants; neurons; neurotransmitters; predator avoidance; social behavior; tranquilizers

DNA methylation plays several roles in regulating neuronal proliferation, differentiation, and physiological functions. The major de novo methyltransferase, DNMT3, controls the DNA methylation pattern in neurons according to environmental stimulations and behavioral regulations. Previous studies dem...