Use of Sildenafil in Heart Transplant Recipients With Pulmonary Hypertension May Prevent Right Heart Failure

• Published in: Transplantation proceedings Vol. 39; no. 9; pp. 2850 - 2852
• Main Authors: Maruszewski, M, Zakliczyński, M, Przybylski, R, Kucewicz-Czech, E, Zembala, M
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.11.2007; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Cardiac Output - drug effects; Drug Administration Schedule; Echocardiography, Transesophageal; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Heart Failure - prevention & control; Heart Transplantation - adverse effects; Humans; Hypertension, Pulmonary - drug therapy; Male; Medical sciences; Middle Aged; Piperazines - therapeutic use; Pneumology; Pulmonary Circulation - drug effects; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Purines - therapeutic use; Sildenafil Citrate; Sulfones - therapeutic use; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Vascular Resistance - drug effects; Vasodilator Agents - therapeutic use; Heart failure; Vasodilator agent; 3',5'-Cyclic-GMP phosphodiesterase; Enzyme; Respiratory disease; Use; Enzyme inhibitor; Cardiovascular disease; Esterases; Transplantation; Phosphoric diester hydrolases; Homotransplantation; Pulmonary hypertension; Phosphodiesterase inhibitor; Phosphodiesterase 5 inhibitor; Medicine; Prevention; Treatment; Heart disease; Surgery; Right heart; Hydrolases; Graft; Sildenafil

Abstract Purpose We performed a short-term outcome analysis of orthotopic heart transplantation (OHT) in patients with pulmonary hypertension (PH) treated perioperatively with oral sildenafil. Methods PH (pulmonary vascular resistance > 2.5 Wood units, and/or transpulmonary gradient > 12 mmHg)...