Antibody blood-brain barrier efflux is modulated by glycan modification

Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on pr...

Full description

Saved in:
Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1861; no. 9; pp. 2228 - 2239
Main Authors Finke, John M., Ayres, Kari R., Brisbin, Ryan P., Hill, Hali A., Wing, Emily E., Banks, William A.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2017
Subjects
Online AccessGet full text

Cover

Loading…