Antibody blood-brain barrier efflux is modulated by glycan modification
Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on pr...
Saved in:
| Published in | Biochimica et biophysica acta Vol. 1861; no. 9; pp. 2228 - 2239 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.09.2017
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on prior evidence, the hypothesis that glycan modification alters antibody blood-brain barrier permeability was tested here.
The blood-brain barrier permeability coefficient Pe of different glycosylated states of anti-amyloid IgG was measured using in vitro models of brain microvascular endothelial cells. Monoclonal antibodies 4G8, with sialic acid, and 6E10, lacking sialic acid, were studied. The amount of sialic acid was determined using quantitative and semi-quantitative surface plasmon resonance methods.
Influx of IgG was not saturable and was largely insensitive to IgG species and glycosylation state. By contrast, efflux of 4G8 efflux was significantly lower than both albumin controls and 6E10. Removal of α2,6-linked sialic acid group present on 12% of 4G8 completely restored efflux to that of 6E10 but increasing the α2,6-sialylated fraction to 15% resulted in no change. Removal of the Fc glycan from 4G8 partially restored efflux. Alternate sialic acid groups with α2,3 and α2,8 linkages, nor on the Fc glycan, were not detected at significant levels on either 4G8 or 6E10.
These results support a model in which surface-sialylated 4G8 inhibits its own efflux and that of asialylated 4G8.
Glycan modification has the potential to increase antibody drug penetration into the brain through efflux inhibition.
•IgG glycan sialic acid inhibits IgG efflux, but not influx, through the blood-brain barrier.•The Fc glycan is required for efflux inhibition by sialylated IgG but does not affect asialylated IgG efflux.•Fab α2,6 sialylation in 12% of IgG inhibits efflux of the asialyalted IgG majority. |
|---|---|
| AbstractList | Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on prior evidence, the hypothesis that glycan modification alters antibody blood-brain barrier permeability was tested here.
The blood-brain barrier permeability coefficient Pe of different glycosylated states of anti-amyloid IgG was measured using in vitro models of brain microvascular endothelial cells. Monoclonal antibodies 4G8, with sialic acid, and 6E10, lacking sialic acid, were studied. The amount of sialic acid was determined using quantitative and semi-quantitative surface plasmon resonance methods.
Influx of IgG was not saturable and was largely insensitive to IgG species and glycosylation state. By contrast, efflux of 4G8 efflux was significantly lower than both albumin controls and 6E10. Removal of α2,6-linked sialic acid group present on 12% of 4G8 completely restored efflux to that of 6E10 but increasing the α2,6-sialylated fraction to 15% resulted in no change. Removal of the Fc glycan from 4G8 partially restored efflux. Alternate sialic acid groups with α2,3 and α2,8 linkages, nor on the Fc glycan, were not detected at significant levels on either 4G8 or 6E10.
These results support a model in which surface-sialylated 4G8 inhibits its own efflux and that of asialylated 4G8.
Glycan modification has the potential to increase antibody drug penetration into the brain through efflux inhibition.
•IgG glycan sialic acid inhibits IgG efflux, but not influx, through the blood-brain barrier.•The Fc glycan is required for efflux inhibition by sialylated IgG but does not affect asialylated IgG efflux.•Fab α2,6 sialylation in 12% of IgG inhibits efflux of the asialyalted IgG majority. BACKGROUNDDrug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on prior evidence, the hypothesis that glycan modification alters antibody blood-brain barrier permeability was tested here.METHODSThe blood-brain barrier permeability coefficient Pe of different glycosylated states of anti-amyloid IgG was measured using in vitro models of brain microvascular endothelial cells. Monoclonal antibodies 4G8, with sialic acid, and 6E10, lacking sialic acid, were studied. The amount of sialic acid was determined using quantitative and semi-quantitative surface plasmon resonance methods.RESULTSInflux of IgG was not saturable and was largely insensitive to IgG species and glycosylation state. By contrast, efflux of 4G8 efflux was significantly lower than both albumin controls and 6E10. Removal of α2,6-linked sialic acid group present on 12% of 4G8 completely restored efflux to that of 6E10 but increasing the α2,6-sialylated fraction to 15% resulted in no change. Removal of the Fc glycan from 4G8 partially restored efflux. Alternate sialic acid groups with α2,3 and α2,8 linkages, nor on the Fc glycan, were not detected at significant levels on either 4G8 or 6E10.CONCLUSIONSThese results support a model in which surface-sialylated 4G8 inhibits its own efflux and that of asialylated 4G8.GENERAL SIGNIFICANCEGlycan modification has the potential to increase antibody drug penetration into the brain through efflux inhibition. Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on prior evidence, the hypothesis that glycan modification alters antibody blood-brain barrier permeability was tested here. The blood-brain barrier permeability coefficient Pe of different glycosylated states of anti-amyloid IgG was measured using in vitro models of brain microvascular endothelial cells. Monoclonal antibodies 4G8, with sialic acid, and 6E10, lacking sialic acid, were studied. The amount of sialic acid was determined using quantitative and semi-quantitative surface plasmon resonance methods. Influx of IgG was not saturable and was largely insensitive to IgG species and glycosylation state. By contrast, efflux of 4G8 efflux was significantly lower than both albumin controls and 6E10. Removal of α2,6-linked sialic acid group present on 12% of 4G8 completely restored efflux to that of 6E10 but increasing the α2,6-sialylated fraction to 15% resulted in no change. Removal of the Fc glycan from 4G8 partially restored efflux. Alternate sialic acid groups with α2,3 and α2,8 linkages, nor on the Fc glycan, were not detected at significant levels on either 4G8 or 6E10. These results support a model in which surface-sialylated 4G8 inhibits its own efflux and that of asialylated 4G8. Glycan modification has the potential to increase antibody drug penetration into the brain through efflux inhibition. |
| Author | Ayres, Kari R. Wing, Emily E. Brisbin, Ryan P. Hill, Hali A. Finke, John M. Banks, William A. |
| AuthorAffiliation | b Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA a Division of Sciences and Mathematics, Interdisciplinary Arts and Sciences, University of Washington Tacoma, Tacoma, WA, USA c Division of Gerontology and Geriatric Medicine, Department of Geriatric Medicine, University of Washington School of Medicine, Seattle, WA, USA |
| AuthorAffiliation_xml | – name: b Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA – name: c Division of Gerontology and Geriatric Medicine, Department of Geriatric Medicine, University of Washington School of Medicine, Seattle, WA, USA – name: a Division of Sciences and Mathematics, Interdisciplinary Arts and Sciences, University of Washington Tacoma, Tacoma, WA, USA |
| Author_xml | – sequence: 1 givenname: John M. orcidid: 0000-0003-1808-6300 surname: Finke fullname: Finke, John M. email: jfinke@u.washington.edu organization: Division of Sciences and Mathematics, Interdisciplinary Arts and Sciences, University of Washington Tacoma, Tacoma, WA, USA – sequence: 2 givenname: Kari R. surname: Ayres fullname: Ayres, Kari R. organization: Division of Sciences and Mathematics, Interdisciplinary Arts and Sciences, University of Washington Tacoma, Tacoma, WA, USA – sequence: 3 givenname: Ryan P. surname: Brisbin fullname: Brisbin, Ryan P. organization: Division of Sciences and Mathematics, Interdisciplinary Arts and Sciences, University of Washington Tacoma, Tacoma, WA, USA – sequence: 4 givenname: Hali A. surname: Hill fullname: Hill, Hali A. organization: Division of Sciences and Mathematics, Interdisciplinary Arts and Sciences, University of Washington Tacoma, Tacoma, WA, USA – sequence: 5 givenname: Emily E. surname: Wing fullname: Wing, Emily E. organization: Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA – sequence: 6 givenname: William A. surname: Banks fullname: Banks, William A. organization: Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28624473$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UU1P3DAQtSqqstD-gwrlyCXBTvyRXCohRGklpF7as2WPx1uvsjbYCWL_PVktBXphLiPNx3sz752Qo5giEvKV0YZRJi82jbVmjbFpKVMNlQ2l_QeyYr1q655SeURWtKO85kyKY3JSyoYuIQbxiRy3vWw5V92K3FzGKdjkdpUdU3K1zSbEypqcA-YKvR_nxyqUapvcPJoJXWV31XrcgYn7WvABzBRS_Ew-ejMW_PKcT8mf79e_r37Ut79ufl5d3tbAZTfV0vEOveLce08tV2gtWNYL8OAlGzzrFCgO0A6wcA_gmO8BOxyWt4wS0J2Sbwfcu9lu0QHGKZtR3-WwNXmnkwn6_04Mf_U6PWghhJKiWwDOnwFyup-xTHobCuA4mohpLpoNjLGhl2o_yg-jkFMpGf0LDaN674He6IMHeu-BplIvHixrZ29PfFn6J_rrD7gI9bDorAsEjIAuZIRJuxTeZ3gCw_aebg |
| CitedBy_id | crossref_primary_10_1002_open_201900167 crossref_primary_10_1016_j_isci_2023_108132 crossref_primary_10_1186_s12987_018_0113_6 crossref_primary_10_1093_glycob_cwae042 crossref_primary_10_1016_j_coviro_2021_01_001 crossref_primary_10_1007_s10555_021_10015_1 crossref_primary_10_1080_19420862_2021_1953220 crossref_primary_10_1038_s41598_020_60438_z crossref_primary_10_2174_1567205016666190321163438 crossref_primary_10_1016_j_addr_2018_10_011 crossref_primary_10_4049_jimmunol_1801337 crossref_primary_10_1371_journal_pone_0195812 crossref_primary_10_3390_cancers14235840 crossref_primary_10_3389_fnins_2018_00254 crossref_primary_10_3389_fonc_2020_01358 crossref_primary_10_1111_imm_13341 |
| Cites_doi | 10.1002/(SICI)1097-4547(19981115)54:4<522::AID-JNR9>3.0.CO;2-O 10.1016/S0076-6879(99)09015-1 10.1111/j.1471-4159.1992.tb10055.x 10.1016/j.neuint.2008.12.002 10.1371/journal.pone.0039565 10.1016/j.nucmedbio.2015.03.003 10.1006/abio.1997.2183 10.1007/BF01181571 10.1006/bbrc.1997.8051 10.1371/journal.pone.0037243 10.1016/S0024-3205(97)00597-3 10.1016/j.drudis.2015.02.008 10.1186/1750-1326-8-36 10.1023/A:1016244500596 10.1371/journal.pone.0120420 10.1016/j.ab.2015.03.032 10.1186/s12974-015-0434-1 10.1074/jbc.M210207200 10.1523/JNEUROSCI.3697-05.2005 10.1001/jama.291.19.2367 10.1126/science.287.5456.1279 10.1073/pnas.85.2.632 10.1126/science.1129594 10.1016/S1474-4422(13)70014-0 10.1208/s12248-009-9129-9 10.1136/jnnp.2003.033399 10.1016/j.nbd.2005.04.007 10.1385/CRIAI:29:3:167 10.1074/jbc.M202833200 10.1111/j.1471-4159.2007.04591.x 10.1016/j.neulet.2008.08.083 10.1208/s12248-008-9055-2 10.1021/ac702566e 10.1046/j.1471-4159.1994.62062404.x 10.1146/annurev.publhealth.23.100901.140525 10.1242/jcs.97.1.127 10.1096/fj.09-138834 10.1093/glycob/cwp038 10.1111/j.1471-4159.2005.03463.x 10.1006/abio.1997.2182 10.1523/JNEUROSCI.0695-06.2006 10.1074/jbc.M109.081828 10.1111/j.1749-6632.2011.06305.x 10.1016/S0169-409X(00)00139-3 10.1097/WNF.0b013e3181cb577a 10.1093/glycob/cwr080 10.1371/journal.pone.0081448 10.1056/NEJMoa1305133 10.1046/j.1471-4159.2002.00840.x 10.1016/S0196-9781(02)00261-9 10.1016/j.brainres.2013.08.035 10.1038/78682 10.4161/mabs.27765 10.1111/j.1471-4159.2004.03020.x 10.1096/fj.14-253369 10.1056/NEJMoa1304839 10.3389/fneng.2013.00007 10.1016/S0165-5728(01)00242-9 10.1016/j.addr.2011.12.005 10.1007/s10719-007-9063-y 10.1371/journal.pone.0028881 10.1016/j.neurobiolaging.2007.12.021 10.1371/journal.pone.0010549 10.1083/jcb.200506103 10.1016/j.tibtech.2015.10.005 10.1016/j.jim.2015.11.009 10.1056/NEJMoa1312889 10.1038/labinvest.3700281 10.3390/antib2020193 10.1038/nature19323 10.1016/0003-2697(89)90602-7 10.1002/pmic.200700968 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M |
| ContentType | Journal Article |
| Copyright | 2017 Elsevier B.V. Copyright © 2017 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2017 Elsevier B.V. – notice: Copyright © 2017 Elsevier B.V. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1016/j.bbagen.2017.06.008 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| EISSN | 1872-8006 1878-2434 |
| EndPage | 2239 |
| ExternalDocumentID | 10_1016_j_bbagen_2017_06_008 28624473 S0304416517301940 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: R03 AG050184 |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABGSF ABMAC ABUDA ABXDB ABYKQ ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 PC. Q38 R2- ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K UQL WH7 WUQ XJT XPP ~G- AAHBH AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 -~X 5PM ABJNI F5P RIG TWZ Y6R |
| ID | FETCH-LOGICAL-c463t-6d43ef744fff0b47ebbcb185cfcf619f137c74cc29ceff9cd1f8ce3e9187a75c3 |
| IEDL.DBID | AIKHN |
| ISSN | 0304-4165 0006-3002 |
| IngestDate | Tue Sep 17 21:15:04 EDT 2024 Fri Oct 25 02:45:17 EDT 2024 Thu Sep 26 17:49:50 EDT 2024 Wed Oct 16 01:00:43 EDT 2024 Fri Feb 23 02:34:14 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | Fab Fc antibody glycosylation Sialic acid Surface plasmon resonance Alzheimer's disease Blood brain barrier |
| Language | English |
| License | Copyright © 2017 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c463t-6d43ef744fff0b47ebbcb185cfcf619f137c74cc29ceff9cd1f8ce3e9187a75c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-1808-6300 |
| OpenAccessLink | https://europepmc.org/articles/pmc5557653?pdf=render |
| PMID | 28624473 |
| PQID | 1911198673 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5557653 proquest_miscellaneous_1911198673 crossref_primary_10_1016_j_bbagen_2017_06_008 pubmed_primary_28624473 elsevier_sciencedirect_doi_10_1016_j_bbagen_2017_06_008 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-09-01 |
| PublicationDateYYYYMMDD | 2017-09-01 |
| PublicationDate_xml | – month: 09 year: 2017 text: 2017-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Biochimica et biophysica acta |
| PublicationTitleAlternate | Biochim Biophys Acta Gen Subj |
| PublicationYear | 2017 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Kontermann, Brinkmann (bb0095) 2015; 20 Dalakas (bb0020) 2004; 291 Raub, Audus (bb0205) 1990; 97 Andersen, Daba, Berntzen, Michaelsen, Sandlie (bb0325) 2010; 285 Zhang, Pardridge (bb0170) 2001; 114 Stine, Dahlgren, Krafft, LaDu (bb0250) 2003; 278 Farrington, Caram-Salas, Haqqani, Brunette, Eldredge, Pepinsky, Antognetti, Baumann, Ding, Garber, Jiang, Delaney, Boileau, Sisk, Stanimirovic (bb0125) 2014; 28 Geisler, Jarvis (bb0280) 2011; 21 Banks, Broadwell (bb0360) 1994; 62 Kyhos, Spak (bb0065) 2013 Rotman, Welling, van den Boogaard, Moursel, van der Graaf, van Buchem, van der Maarel, van der Weerd (bb0130) 2015; 42 Hoheisel, Nitz, Franke, Wegener, Hakvoort, Tilling, Galla (bb0310) 1998; 244 Banks, Gray, Erickson, Salameh, Damodarasamy, Sheibani, Meabon, Wing, Morofuji, Cook, Reed (bb0320) 2015; 12 Dohgu, Ryerse, Robinson, Banks (bb0215) 2012; 7 Poduslo, Ramakrishnan, Holasek, Ramirez-Alvarado, Kandimalla, Gilles, Curran, Wengenack (bb0110) 2007; 102 Monnier, Vigouroux, Tassew (bb0120) 2013; 2013 Wilcock, Alamed, Gottschall, Grimm, Rosenthal, Pons, Ronan, Symmonds, Gordon, Morgan (bb0220) 2006; 26 Sloane, Zimmerman, Suchindran, Reed, Wang, Boustani, Sudha (bb0005) 2002; 23 Pourpak, Aghamohammadi, Sedighipour, Farhoudi, Movahedi, Gharagozlou, Chavoshzadeh, Jadid, Rezaei, Moin (bb0030) 2006; 39 Siemers, Friedrich, Dean, Gonzales, Farlow, Paul, Demattos (bb0060) 2010; 33 Garg, Balthasar (bb0190) 2009; 11 Pardridge, Kang, Buciak, Yang (bb0150) 1995; 12 Richalet-Secordel, Rauffer-Bruyere, Christensen, Ofenloch-Haehnle, Seidel, Van Regenmortel (bb0265) 1997; 249 Chen, Wang, Fauty, Fang, Hamuro, Hussain, Prueksaritanont (bb0185) 2014; 6 Sand, Bern, Nilsen, Noordzij, Sandlie, Andersen (bb0335) 2014; 5 Mimura, Kelly, Unwin, Albrecht, Jefferis, Goodall, Mizukami, Mimura-Kimura, Matsumoto, Ueoka, Rudd (bb0355) 2016; 428 Salloway, Sperling, Fox, Blennow, Klunk, Raskind, Sabbagh, Honig, Porsteinsson, Ferris, Reichert, Ketter, Nejadnik, Guenzler, Miloslavsky, Wang, Lu, Lull, Tudor, Liu, Grundman, Yuen, Black, Brashear, Bapineuzumab, I. Clinical Trial (bb0080) 2014; 370 DeLano, Ultsch, de Vos, Wells (bb0180) 2000; 287 Doody, Thomas, Farlow, Iwatsubo, Vellas, Joffe, Kieburtz, Raman, Sun, Aisen, Siemers, Liu-Seifert, Mohs, C. Alzheimer's Disease Cooperative Study Steering, G. Solanezumab Study (bb0075) 2014; 370 Bard, Cannon, Barbour, Burke, Games, Grajeda, Guido, Hu, Huang, Johnson-Wood, Khan, Kholodenko, Lee, Lieberburg, Motter, Nguyen, Soriano, Vasquez, Weiss, Welch, Seubert, Schenk, Yednock (bb0055) 2000; 6 Kaneko, Nimmerjahn, Ravetch (bb0380) 2006; 313 Banks (bb0090) 2012; 64 Lee, Engelhardt, Lesley, Bickel, Pardridge (bb0145) 2000; 292 Anthony, Wermeling, Ravetch (bb0375) 2012; 1253 Perriere, Demeuse, Garcia, Regina, Debray, Andreux, Couvreur, Scherrmann, Temsamani, Couraud, Deli, Roux (bb0300) 2005; 93 Herve, Ghinea, Scherrmann (bb0345) 2008; 10 Bacher, Depboylu, Du, Noelker, Oertel, Behr, Henriksen, Behe, Dodel (bb0225) 2009; 449 Tamura, Hamajima, Matsui, Yanoma, Narita, Tajima, Xin, Klinman, Okuda (bb0115) 2005; 20 Angata, Kerr, Greaves, Varki, Crocker, Varki (bb0285) 2002; 277 Stadlmann, Pabst, Kolarich, Kunert, Altmann (bb0330) 2008; 8 Kasermann, Boerema, Ruegsegger, Hofmann, Wymann, Zuercher, Miescher (bb0390) 2012; 7 Abulrob, Sprong, Van Bergen, Henegouwen, Stanimirovic (bb0155) 2005; 95 Banks, Terrell, Farr, Robinson, Nonaka, Morley (bb0100) 2002; 23 Banks, Kastin (bb0210) 1998; 54 Tagawa, Mezzacasa, Hayer, Longatti, Pelkmans, Helenius (bb0340) 2005; 170 Crisostomo, Dang, Digambaranath, Klaver, Loeffler, Payne, Smith, Yokom, Finke (bb0230) 2015; 481 Christensen (bb0260) 1997; 249 Broadwell, Balin, Salcman (bb0195) 1988; 85 Bickel, Yoshikawa, Pardridge (bb0135) 2001; 46 Deane, Sagare, Hamm, Parisi, LaRue, Guo, Wu, Holtzman, Zlokovic (bb0165) 2005; 25 Lemere (bb0010) 2013; 8 Toubi, Etzioni (bb0035) 2005; 29 Neves, Aires-da-Silva, Corte Real, Castanho (bb0140) 2016; 34 Sevigny, Chiao, Bussiere, Weinreb, Williams, Maier, Dunstan, Salloway, Chen, Ling, O'Gorman, Qian, Arastu, Li, Chollate, Brennan, Quintero-Monzon, Scannevin, Arnold, Engber, Rhodes, Ferrero, Hang, Mikulskis, Grimm, Hock, Nitsch, Sandrock (bb0085) 2016; 537 Schlachetzki, Zhu, Pardridge (bb0365) 2002; 81 Hamid, Robert, Daud, Hodi, Hwu, Kefford, Wolchok, Hersey, Joseph, Weber, Dronca, Gangadhar, Patnaik, Zarour, Joshua, Gergich, Elassaiss-Schaap, Algazi, Mateus, Boasberg, Tumeh, Chmielowski, Ebbinghaus, Li, Kang, Ribas (bb0040) 2013; 369 Dehouck, Jolliet-Riant, Bree, Fruchart, Cecchelli, Tillement (bb0315) 1992; 58 Dodel, Rominger, Bartenstein, Barkhof, Blennow, Forster, Winter, Bach, Popp, Alferink, Wiltfang, Buerger, Otto, Antuono, Jacoby, Richter, Stevens, Melamed, Goldstein, Haag, Wietek, Farlow, Jessen (bb0070) 2013; 12 Dodel, Du, Depboylu, Hampel, Frolich, Haag, Hemmeter, Paulsen, Teipel, Brettschneider, Spottke, Nolker, Moller, Wei, Farlow, Sommer, Oertel (bb0045) 2004; 75 Linman, Taylor, Yu, Chen, Cheng (bb0270) 2008; 80 Jacob, Hack, Chiang, Garcia, Quigg, Alexander (bb0295) 2010; 24 Coisne, Dehouck, Faveeuw, Delplace, Miller, Landry, Morissette, Fenart, Cecchelli, Tremblay, Dehouck (bb0290) 2005; 85 Sarkar, Curran, Mahlum, Decklever, Wengenack, Blahnik, Hoesley, Lowe, Poduslo, Jenkins (bb0160) 2011; 6 Kwon, Crisostomo, Smalls, Finke (bb0235) 2015; 10 Banks, Kastin, Akerstrom (bb0200) 1997; 61 Ogata, Shimizu, Franco, Touma, Kanegaye, Choudhury, Naidu, Kanda, Hoang, Hibberd, Tremoulet, Varki, Burns (bb0385) 2013; 8 Perdivara, Deterding, Cozma, Tomer, Przybylski (bb0240) 2009; 19 Nakagawa, Deli, Kawaguchi, Shimizudani, Shimono, Kittel, Tanaka, Niwa (bb0305) 2009; 54 Cooper, Ciambrone, Kliwinski, Maze, Johnson, Li, Feng, Hornby (bb0175) 2013; 1534 Wong, Ye, Levy, Rothstein, Bergles, Searson (bb0350) 2013; 6 Zagorski, Yang, Shao, Ma, Zeng, Hong (bb0245) 1999; 309 Villegas, Broadwell (bb0370) 1993; 22 Ou, Hsieh, Chiou, Chang, Ger (bb0025) 2006; 47 Wu, Wu, Tsai, Yang, Sharon, Herp (bb0275) 2007; 24 Relkin, Szabo, Adamiak, Burgut, Monthe, Lent, Younkin, Younkin, Schiff, Weksler (bb0050) 2009; 30 Gill, von Hippel (bb0255) 1989; 182 Jordao, Ayala-Grosso, Markham, Huang, Chopra, McLaurin, Hynynen, Aubert (bb0105) 2010; 5 McLean, Cherny, Fraser, Fuller, Smith, Beyreuther, Bush, Masters (bb0015) 1999; 46 26608623 - J Neuroinflammation. 2015 Nov 25;12:223 16391391 - Clin Rev Allergy Immunol. 2005 Dec;29(3):167-72 22202501 - Adv Drug Deliv Rev. 2012 May 15;64(7):629-39 9284088 - Life Sci. 1997;61(9):PL119-25 11910061 - Annu Rev Public Health. 2002;23:213-31 18786612 - Neurosci Lett. 2009 Jan 16;449(3):240-5 16129785 - J Cell Biol. 2005 Aug 29;170(5):769-79 15908227 - Neurobiol Dis. 2005 Nov;20(2):541-9 9212867 - Anal Biochem. 1997 Jul 1;249(2):153-64 24492305 - MAbs. 2014 Mar-Apr;6(2):502-8 12535702 - Peptides. 2002 Dec;23(12):2223-6 15908914 - Lab Invest. 2005 Jun;85(6):734-46 9212868 - Anal Biochem. 1997 Jul 1;249(2):165-73 12067234 - J Neurochem. 2002 Apr;81(1):203-6 18461973 - Anal Chem. 2008 Jun 1;80(11):4007-13 15377700 - J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1472-4 23724846 - N Engl J Med. 2013 Jul 11;369(2):134-44 20375655 - Clin Neuropharmacol. 2010 Mar-Apr;33(2):67-73 24009582 - Front Neuroeng. 2013 Aug 30;6:7 9822162 - J Neurosci Res. 1998 Nov 15;54(4):522-9 18655055 - Proteomics. 2008 Jul;8(14):2858-71 10589538 - Ann Neurol. 1999 Dec;46(6):860-6 18726697 - AAPS J. 2008 Sep;10 (3):455-72 15150209 - JAMA. 2004 May 19;291(19):2367-75 19318519 - Glycobiology. 2009 Sep;19(9):958-70 10678837 - Science. 2000 Feb 18;287(5456):1279-83 22675478 - PLoS One. 2012;7(6):e37243 25070367 - FASEB J. 2014 Nov;28(11):4764-78 7680372 - J Neurocytol. 1993 Feb;22(2):67-80 27582220 - Nature. 2016 Aug 31;537(7618):50-6 21863598 - Glycobiology. 2011 Aug;21(8):988-93 19111869 - Neurochem Int. 2009 Mar-Apr;54(3-4):253-63 7667183 - Pharm Res. 1995 Jun;12(6):807-16 16271053 - J Neurochem. 2005 Nov;95(4):1201-14 11240028 - J Neuroimmunol. 2001 Mar 1;114(1-2):168-72 22288459 - Ann N Y Acad Sci. 2012 Apr;1253:170-80 16888140 - Science. 2006 Aug 4;313(5787):670-3 26627984 - J Immunol Methods. 2016 Jan;428:30-6 10507025 - Methods Enzymol. 1999;309:189-204 16604243 - J Microbiol Immunol Infect. 2006 Apr;39(2):114-20 2258384 - J Cell Sci. 1990 Sep;97 ( Pt 1):127-38 24324693 - PLoS One. 2013 Dec 06;8(12):e81448 22216132 - PLoS One. 2011;6(12):e28881 16354907 - J Neurosci. 2005 Dec 14;25(50):11495-503 24450891 - N Engl J Med. 2014 Jan 23;370(4):322-33 23978455 - Brain Res. 2013 Oct 9;1534:13-21 25921794 - Anal Biochem. 2015 Jul 15;481:43-54 19636712 - AAPS J. 2009 Sep;11(3):553-7 1560234 - J Neurochem. 1992 May;58(5):1790-7 10688622 - J Pharmacol Exp Ther. 2000 Mar;292(3):1048-52 17352309 - Acta Paediatr Taiwan. 2006 Sep-Oct;47(5):226-31 24450890 - N Engl J Med. 2014 Jan 23;370(4):311-21 9514852 - Biochem Biophys Res Commun. 1998 Mar 6;244(1):312-6 25728220 - Drug Discov Today. 2015 Jul;20(7):838-47 25674083 - Front Immunol. 2015 Jan 26;5:682 15816851 - J Neurochem. 2005 Apr;93(2):279-89 2610349 - Anal Biochem. 1989 Nov 1;182(2):319-26 22761827 - PLoS One. 2012;7(6):e39565 24148220 - Mol Neurodegener. 2013 Oct 22;8:36 12499373 - J Biol Chem. 2003 Mar 28;278(13):11612-22 17596213 - J Neurochem. 2007 Jul;102(2):420-33 25826319 - PLoS One. 2015 Mar 31;10(3):e0120420 18294736 - Neurobiol Aging. 2009 Nov;30(11):1728-36 17805962 - Glycoconj J. 2007 Dec;24(9):591-604 20485502 - PLoS One. 2010 May 11;5(5):e10549 7514652 - J Neurochem. 1994 Jun;62(6):2404-19 23375965 - Lancet Neurol. 2013 Mar;12(3):233-43 2448779 - Proc Natl Acad Sci U S A. 1988 Jan;85(2):632-6 11259843 - Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):247-79 11986327 - J Biol Chem. 2002 Jul 5;277(27):24466-74 10932230 - Nat Med. 2000 Aug;6(8):916-9 16707786 - J Neurosci. 2006 May 17;26(20):5340-6 20018855 - J Biol Chem. 2010 Feb 12;285(7):4826-36 20065106 - FASEB J. 2010 Jun;24(6):1682-8 25960433 - Nucl Med Biol. 2015 Aug;42(8):695-702 Banks (10.1016/j.bbagen.2017.06.008_bb0100) 2002; 23 Banks (10.1016/j.bbagen.2017.06.008_bb0090) 2012; 64 Kontermann (10.1016/j.bbagen.2017.06.008_bb0095) 2015; 20 Monnier (10.1016/j.bbagen.2017.06.008_bb0120) 2013; 2013 Zhang (10.1016/j.bbagen.2017.06.008_bb0170) 2001; 114 Zagorski (10.1016/j.bbagen.2017.06.008_bb0245) 1999; 309 Geisler (10.1016/j.bbagen.2017.06.008_bb0280) 2011; 21 Hoheisel (10.1016/j.bbagen.2017.06.008_bb0310) 1998; 244 Banks (10.1016/j.bbagen.2017.06.008_bb0320) 2015; 12 Poduslo (10.1016/j.bbagen.2017.06.008_bb0110) 2007; 102 Deane (10.1016/j.bbagen.2017.06.008_bb0165) 2005; 25 Farrington (10.1016/j.bbagen.2017.06.008_bb0125) 2014; 28 Cooper (10.1016/j.bbagen.2017.06.008_bb0175) 2013; 1534 Kyhos (10.1016/j.bbagen.2017.06.008_bb0065) Sarkar (10.1016/j.bbagen.2017.06.008_bb0160) 2011; 6 Coisne (10.1016/j.bbagen.2017.06.008_bb0290) 2005; 85 Dodel (10.1016/j.bbagen.2017.06.008_bb0070) 2013; 12 Jacob (10.1016/j.bbagen.2017.06.008_bb0295) 2010; 24 Dodel (10.1016/j.bbagen.2017.06.008_bb0045) 2004; 75 Bickel (10.1016/j.bbagen.2017.06.008_bb0135) 2001; 46 Richalet-Secordel (10.1016/j.bbagen.2017.06.008_bb0265) 1997; 249 Schlachetzki (10.1016/j.bbagen.2017.06.008_bb0365) 2002; 81 Wu (10.1016/j.bbagen.2017.06.008_bb0275) 2007; 24 Kaneko (10.1016/j.bbagen.2017.06.008_bb0380) 2006; 313 Abulrob (10.1016/j.bbagen.2017.06.008_bb0155) 2005; 95 Crisostomo (10.1016/j.bbagen.2017.06.008_bb0230) 2015; 481 Kasermann (10.1016/j.bbagen.2017.06.008_bb0390) 2012; 7 Anthony (10.1016/j.bbagen.2017.06.008_bb0375) 2012; 1253 Sand (10.1016/j.bbagen.2017.06.008_bb0335) 2014; 5 Gill (10.1016/j.bbagen.2017.06.008_bb0255) 1989; 182 Neves (10.1016/j.bbagen.2017.06.008_bb0140) 2016; 34 Toubi (10.1016/j.bbagen.2017.06.008_bb0035) 2005; 29 Dalakas (10.1016/j.bbagen.2017.06.008_bb0020) 2004; 291 Andersen (10.1016/j.bbagen.2017.06.008_bb0325) 2010; 285 Tagawa (10.1016/j.bbagen.2017.06.008_bb0340) 2005; 170 Tamura (10.1016/j.bbagen.2017.06.008_bb0115) 2005; 20 Angata (10.1016/j.bbagen.2017.06.008_bb0285) 2002; 277 Stadlmann (10.1016/j.bbagen.2017.06.008_bb0330) 2008; 8 Pourpak (10.1016/j.bbagen.2017.06.008_bb0030) 2006; 39 Salloway (10.1016/j.bbagen.2017.06.008_bb0080) 2014; 370 Stine (10.1016/j.bbagen.2017.06.008_bb0250) 2003; 278 Raub (10.1016/j.bbagen.2017.06.008_bb0205) 1990; 97 Perriere (10.1016/j.bbagen.2017.06.008_bb0300) 2005; 93 Wilcock (10.1016/j.bbagen.2017.06.008_bb0220) 2006; 26 Mimura (10.1016/j.bbagen.2017.06.008_bb0355) 2016; 428 Siemers (10.1016/j.bbagen.2017.06.008_bb0060) 2010; 33 Bard (10.1016/j.bbagen.2017.06.008_bb0055) 2000; 6 Dehouck (10.1016/j.bbagen.2017.06.008_bb0315) 1992; 58 Ogata (10.1016/j.bbagen.2017.06.008_bb0385) 2013; 8 Hamid (10.1016/j.bbagen.2017.06.008_bb0040) 2013; 369 Ou (10.1016/j.bbagen.2017.06.008_bb0025) 2006; 47 Wong (10.1016/j.bbagen.2017.06.008_bb0350) 2013; 6 McLean (10.1016/j.bbagen.2017.06.008_bb0015) 1999; 46 Jordao (10.1016/j.bbagen.2017.06.008_bb0105) 2010; 5 Banks (10.1016/j.bbagen.2017.06.008_bb0210) 1998; 54 Villegas (10.1016/j.bbagen.2017.06.008_bb0370) 1993; 22 Relkin (10.1016/j.bbagen.2017.06.008_bb0050) 2009; 30 Banks (10.1016/j.bbagen.2017.06.008_bb0200) 1997; 61 Linman (10.1016/j.bbagen.2017.06.008_bb0270) 2008; 80 Lemere (10.1016/j.bbagen.2017.06.008_bb0010) 2013; 8 Pardridge (10.1016/j.bbagen.2017.06.008_bb0150) 1995; 12 Kwon (10.1016/j.bbagen.2017.06.008_bb0235) 2015; 10 Banks (10.1016/j.bbagen.2017.06.008_bb0360) 1994; 62 Perdivara (10.1016/j.bbagen.2017.06.008_bb0240) 2009; 19 Nakagawa (10.1016/j.bbagen.2017.06.008_bb0305) 2009; 54 Herve (10.1016/j.bbagen.2017.06.008_bb0345) 2008; 10 Lee (10.1016/j.bbagen.2017.06.008_bb0145) 2000; 292 Dohgu (10.1016/j.bbagen.2017.06.008_bb0215) 2012; 7 Broadwell (10.1016/j.bbagen.2017.06.008_bb0195) 1988; 85 Sevigny (10.1016/j.bbagen.2017.06.008_bb0085) 2016; 537 Sloane (10.1016/j.bbagen.2017.06.008_bb0005) 2002; 23 DeLano (10.1016/j.bbagen.2017.06.008_bb0180) 2000; 287 Bacher (10.1016/j.bbagen.2017.06.008_bb0225) 2009; 449 Christensen (10.1016/j.bbagen.2017.06.008_bb0260) 1997; 249 Rotman (10.1016/j.bbagen.2017.06.008_bb0130) 2015; 42 Doody (10.1016/j.bbagen.2017.06.008_bb0075) 2014; 370 Garg (10.1016/j.bbagen.2017.06.008_bb0190) 2009; 11 Chen (10.1016/j.bbagen.2017.06.008_bb0185) 2014; 6 |
| References_xml | – volume: 2013 start-page: 193 year: 2013 end-page: 208 ident: bb0120 article-title: In vivo applications of single chain Fv (variable domain) (scFv) fragments publication-title: Antibodies contributor: fullname: Tassew – volume: 30 start-page: 1728 year: 2009 end-page: 1736 ident: bb0050 article-title: 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease publication-title: Neurobiol. Aging contributor: fullname: Weksler – volume: 46 start-page: 247 year: 2001 end-page: 279 ident: bb0135 article-title: Delivery of peptides and proteins through the blood-brain barrier publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Pardridge – volume: 6 start-page: 502 year: 2014 end-page: 508 ident: bb0185 article-title: The effect of the neonatal Fc receptor on human IgG biodistribution in mice publication-title: MAbs contributor: fullname: Prueksaritanont – volume: 10 year: 2015 ident: bb0235 article-title: Anti-abeta oligomer IgG and surface sialic acid in intravenous immunoglobulin: measurement and correlation with clinical outcomes in Alzheimer's disease treatment publication-title: PLoS One contributor: fullname: Finke – volume: 33 start-page: 67 year: 2010 end-page: 73 ident: bb0060 article-title: Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease publication-title: Clin. Neuropharmacol. contributor: fullname: Demattos – volume: 20 start-page: 838 year: 2015 end-page: 847 ident: bb0095 article-title: Bispecific antibodies publication-title: Drug Discov. Today contributor: fullname: Brinkmann – volume: 75 start-page: 1472 year: 2004 end-page: 1474 ident: bb0045 article-title: Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease publication-title: J. Neurol. Neurosurg. Psychiatry contributor: fullname: Oertel – volume: 369 start-page: 134 year: 2013 end-page: 144 ident: bb0040 article-title: Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma publication-title: N. Engl. J. Med. contributor: fullname: Ribas – volume: 20 start-page: 541 year: 2005 end-page: 549 ident: bb0115 article-title: The F(ab)′2 fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain publication-title: Neurobiol. Dis. contributor: fullname: Okuda – volume: 12 start-page: 807 year: 1995 end-page: 816 ident: bb0150 article-title: Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate publication-title: Pharm. Res. contributor: fullname: Yang – volume: 62 start-page: 2404 year: 1994 end-page: 2419 ident: bb0360 article-title: Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin, and albumin: pharmacokinetic and morphological assessments publication-title: J. Neurochem. contributor: fullname: Broadwell – volume: 97 start-page: 127 year: 1990 end-page: 138 ident: bb0205 article-title: Adsorptive endocytosis and membrane recycling by cultured primary bovine brain microvessel endothelial cell monolayers publication-title: J. Cell Sci. contributor: fullname: Audus – volume: 313 start-page: 670 year: 2006 end-page: 673 ident: bb0380 article-title: Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation publication-title: Science contributor: fullname: Ravetch – volume: 102 start-page: 420 year: 2007 end-page: 433 ident: bb0110 article-title: In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques publication-title: J. Neurochem. contributor: fullname: Wengenack – volume: 244 start-page: 312 year: 1998 end-page: 316 ident: bb0310 article-title: Hydrocortisone reinforces the blood-brain barrier properties in a serum free cell culture system publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Galla – volume: 11 start-page: 553 year: 2009 end-page: 557 ident: bb0190 article-title: Investigation of the influence of FcRn on the distribution of IgG to the brain publication-title: AAPS J. contributor: fullname: Balthasar – volume: 85 start-page: 734 year: 2005 end-page: 746 ident: bb0290 article-title: Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium publication-title: Lab. Investig. contributor: fullname: Dehouck – volume: 309 start-page: 189 year: 1999 end-page: 204 ident: bb0245 article-title: Methodological and chemical factors affecting amyloid beta peptide amyloidogenicity publication-title: Methods Enzymol. contributor: fullname: Hong – volume: 370 start-page: 311 year: 2014 end-page: 321 ident: bb0075 article-title: Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease publication-title: N. Engl. J. Med. contributor: fullname: G. Solanezumab Study – volume: 85 start-page: 632 year: 1988 end-page: 636 ident: bb0195 article-title: Transcytotic pathway for blood-borne protein through the blood-brain barrier publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Salcman – volume: 182 start-page: 319 year: 1989 end-page: 326 ident: bb0255 article-title: Calculation of protein extinction coefficients from amino acid sequence data publication-title: Anal. Biochem. contributor: fullname: von Hippel – volume: 26 start-page: 5340 year: 2006 end-page: 5346 ident: bb0220 article-title: Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice publication-title: J. Neurosci. contributor: fullname: Morgan – volume: 8 start-page: 2858 year: 2008 end-page: 2871 ident: bb0330 article-title: Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides publication-title: Proteomics contributor: fullname: Altmann – volume: 537 start-page: 50 year: 2016 end-page: 56 ident: bb0085 article-title: The antibody aducanumab reduces Abeta plaques in Alzheimer's disease publication-title: Nature contributor: fullname: Sandrock – volume: 61 start-page: PL119 year: 1997 end-page: PL125 ident: bb0200 article-title: HIV-1 protein gp120 crosses the blood-brain barrier: role of adsorptive endocytosis publication-title: Life Sci. contributor: fullname: Akerstrom – volume: 277 start-page: 24466 year: 2002 end-page: 24474 ident: bb0285 article-title: Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia publication-title: J. Biol. Chem. contributor: fullname: Varki – volume: 81 start-page: 203 year: 2002 end-page: 206 ident: bb0365 article-title: Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier publication-title: J. Neurochem. contributor: fullname: Pardridge – volume: 249 start-page: 153 year: 1997 end-page: 164 ident: bb0260 article-title: Theoretical analysis of protein concentration determination using biosensor technology under conditions of partial mass transport limitation publication-title: Anal. Biochem. contributor: fullname: Christensen – volume: 42 start-page: 695 year: 2015 end-page: 702 ident: bb0130 article-title: Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake publication-title: Nucl. Med. Biol. contributor: fullname: van der Weerd – volume: 481 start-page: 43 year: 2015 end-page: 54 ident: bb0230 article-title: Kinetic analysis of IgG antibodies to beta-amyloid oligomers with surface plasmon resonance publication-title: Anal. Biochem. contributor: fullname: Finke – volume: 54 start-page: 253 year: 2009 end-page: 263 ident: bb0305 article-title: A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes publication-title: Neurochem. Int. contributor: fullname: Niwa – volume: 8 year: 2013 ident: bb0385 article-title: Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin g publication-title: PLoS One contributor: fullname: Burns – volume: 12 start-page: 233 year: 2013 end-page: 243 ident: bb0070 article-title: Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer's disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial publication-title: Lancet Neurol. contributor: fullname: Jessen – volume: 114 start-page: 168 year: 2001 end-page: 172 ident: bb0170 article-title: Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier publication-title: J. Neuroimmunol. contributor: fullname: Pardridge – volume: 29 start-page: 167 year: 2005 end-page: 172 ident: bb0035 article-title: Intravenous immunoglobulin in immunodeficiency states: state of the art publication-title: Clin Rev Allergy Immunol contributor: fullname: Etzioni – volume: 95 start-page: 1201 year: 2005 end-page: 1214 ident: bb0155 article-title: The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells publication-title: J. Neurochem. contributor: fullname: Stanimirovic – volume: 5 start-page: 682 year: 2014 ident: bb0335 article-title: Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics publication-title: Front. Immunol. contributor: fullname: Andersen – volume: 292 start-page: 1048 year: 2000 end-page: 1052 ident: bb0145 article-title: Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Pardridge – volume: 28 start-page: 4764 year: 2014 end-page: 4778 ident: bb0125 article-title: A novel platform for engineering blood-brain barrier-crossing bispecific biologics publication-title: FASEB J. contributor: fullname: Stanimirovic – volume: 39 start-page: 114 year: 2006 end-page: 120 ident: bb0030 article-title: Effect of regular intravenous immunoglobulin therapy on prevention of pneumonia in patients with common variable immunodeficiency publication-title: J. Microbiol. Immunol. Infect. contributor: fullname: Moin – volume: 6 start-page: 916 year: 2000 end-page: 919 ident: bb0055 article-title: Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease publication-title: Nat. Med. contributor: fullname: Yednock – volume: 24 start-page: 591 year: 2007 end-page: 604 ident: bb0275 article-title: Differential affinities of publication-title: Glycoconj. J. contributor: fullname: Herp – volume: 287 start-page: 1279 year: 2000 end-page: 1283 ident: bb0180 article-title: Convergent solutions to binding at a protein-protein interface publication-title: Science contributor: fullname: Wells – volume: 449 start-page: 240 year: 2009 end-page: 245 ident: bb0225 article-title: Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease publication-title: Neurosci. Lett. contributor: fullname: Dodel – volume: 54 start-page: 522 year: 1998 end-page: 529 ident: bb0210 article-title: Characterization of lectin-mediated brain uptake of HIV-1 GP120 publication-title: J. Neurosci. Res. contributor: fullname: Kastin – volume: 1253 start-page: 170 year: 2012 end-page: 180 ident: bb0375 article-title: Novel roles for the IgG Fc glycan publication-title: Ann. N. Y. Acad. Sci. contributor: fullname: Ravetch – volume: 5 year: 2010 ident: bb0105 article-title: Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease publication-title: PLoS One contributor: fullname: Aubert – volume: 8 start-page: 36 year: 2013 ident: bb0010 article-title: Immunotherapy for Alzheimer's disease: hoops and hurdles publication-title: Mol. Neurodegener. contributor: fullname: Lemere – volume: 47 start-page: 226 year: 2006 end-page: 231 ident: bb0025 article-title: A comparative study of initial use of intravenous immunoglobulin and prednisolone treatments in childhood idiopathic thrombocytopenic purpur publication-title: Acta Paediatr. Taiwan. contributor: fullname: Ger – volume: 12 start-page: 223 year: 2015 ident: bb0320 article-title: Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit publication-title: J. Neuroinflammation contributor: fullname: Reed – volume: 24 start-page: 1682 year: 2010 end-page: 1688 ident: bb0295 article-title: C5a alters blood-brain barrier integrity in experimental lupus publication-title: FASEB J. contributor: fullname: Alexander – volume: 249 start-page: 165 year: 1997 end-page: 173 ident: bb0265 article-title: Concentration measurement of unpurified proteins using biosensor technology under conditions of partial mass transport limitation publication-title: Anal. Biochem. contributor: fullname: Van Regenmortel – volume: 21 start-page: 988 year: 2011 end-page: 993 ident: bb0280 article-title: Effective glycoanalysis with publication-title: Glycobiology contributor: fullname: Jarvis – volume: 93 start-page: 279 year: 2005 end-page: 289 ident: bb0300 article-title: Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties publication-title: J. Neurochem. contributor: fullname: Roux – volume: 22 start-page: 67 year: 1993 end-page: 80 ident: bb0370 article-title: Transcytosis of protein through the mammalian cerebral epithelium and endothelium. II. Adsorptive transcytosis of WGA-HRP and the blood-brain and brain-blood barriers publication-title: J. Neurocytol. contributor: fullname: Broadwell – volume: 170 start-page: 769 year: 2005 end-page: 779 ident: bb0340 article-title: Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters publication-title: J. Cell Biol. contributor: fullname: Helenius – volume: 428 start-page: 30 year: 2016 end-page: 36 ident: bb0355 article-title: Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines publication-title: J. Immunol. Methods contributor: fullname: Rudd – volume: 7 year: 2012 ident: bb0390 article-title: Analysis and functional consequences of increased Fab-sialylation of intravenous immunoglobulin (IVIG) after lectin fractionation publication-title: PLoS One contributor: fullname: Miescher – volume: 6 start-page: 7 year: 2013 ident: bb0350 article-title: The blood-brain barrier: an engineering perspective publication-title: Front. Neuroeng. contributor: fullname: Searson – year: 2013 ident: bb0065 article-title: GAP 18-month study results contributor: fullname: Spak – volume: 278 start-page: 11612 year: 2003 end-page: 11622 ident: bb0250 article-title: In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis publication-title: J. Biol. Chem. contributor: fullname: LaDu – volume: 370 start-page: 322 year: 2014 end-page: 333 ident: bb0080 article-title: Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease publication-title: N. Engl. J. Med. contributor: fullname: Bapineuzumab, I. Clinical Trial – volume: 6 year: 2011 ident: bb0160 article-title: A carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain publication-title: PLoS One contributor: fullname: Jenkins – volume: 23 start-page: 2223 year: 2002 end-page: 2226 ident: bb0100 article-title: Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease publication-title: Peptides contributor: fullname: Morley – volume: 291 start-page: 2367 year: 2004 end-page: 2375 ident: bb0020 article-title: Intravenous immunoglobulin in autoimmune neuromuscular diseases publication-title: JAMA contributor: fullname: Dalakas – volume: 285 start-page: 4826 year: 2010 end-page: 4836 ident: bb0325 article-title: Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding publication-title: J. Biol. Chem. contributor: fullname: Sandlie – volume: 34 start-page: 36 year: 2016 end-page: 48 ident: bb0140 article-title: Antibody approaches to treat brain diseases publication-title: Trends Biotechnol. contributor: fullname: Castanho – volume: 25 start-page: 11495 year: 2005 end-page: 11503 ident: bb0165 article-title: IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal fc receptor publication-title: J. Neurosci. contributor: fullname: Zlokovic – volume: 46 start-page: 860 year: 1999 end-page: 866 ident: bb0015 article-title: Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease publication-title: Ann. Neurol. contributor: fullname: Masters – volume: 7 year: 2012 ident: bb0215 article-title: Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier publication-title: PLoS One contributor: fullname: Banks – volume: 23 start-page: 213 year: 2002 end-page: 231 ident: bb0005 article-title: The public health impact of Alzheimer's disease, 2000–2050: potential implication of treatment advances publication-title: Annu. Rev. Public Health contributor: fullname: Sudha – volume: 19 start-page: 958 year: 2009 end-page: 970 ident: bb0240 article-title: Glycosylation profiles of epitope-specific anti-beta-amyloid antibodies revealed by liquid chromatography-mass spectrometry publication-title: Glycobiology contributor: fullname: Przybylski – volume: 80 start-page: 4007 year: 2008 end-page: 4013 ident: bb0270 article-title: Surface plasmon resonance study of protein-carbohydrate interactions using biotinylated sialosides publication-title: Anal. Chem. contributor: fullname: Cheng – volume: 58 start-page: 1790 year: 1992 end-page: 1797 ident: bb0315 article-title: Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models publication-title: J. Neurochem. contributor: fullname: Tillement – volume: 64 start-page: 629 year: 2012 end-page: 639 ident: bb0090 article-title: Drug delivery to the brain in Alzheimer's disease: consideration of the blood-brain barrier publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Banks – volume: 1534 start-page: 13 year: 2013 end-page: 21 ident: bb0175 article-title: Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn publication-title: Brain Res. contributor: fullname: Hornby – volume: 10 start-page: 455 year: 2008 end-page: 472 ident: bb0345 article-title: CNS delivery via adsorptive transcytosis publication-title: AAPS J. contributor: fullname: Scherrmann – volume: 54 start-page: 522 year: 1998 ident: 10.1016/j.bbagen.2017.06.008_bb0210 article-title: Characterization of lectin-mediated brain uptake of HIV-1 GP120 publication-title: J. Neurosci. Res. doi: 10.1002/(SICI)1097-4547(19981115)54:4<522::AID-JNR9>3.0.CO;2-O contributor: fullname: Banks – volume: 309 start-page: 189 year: 1999 ident: 10.1016/j.bbagen.2017.06.008_bb0245 article-title: Methodological and chemical factors affecting amyloid beta peptide amyloidogenicity publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(99)09015-1 contributor: fullname: Zagorski – volume: 58 start-page: 1790 year: 1992 ident: 10.1016/j.bbagen.2017.06.008_bb0315 article-title: Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1992.tb10055.x contributor: fullname: Dehouck – volume: 54 start-page: 253 year: 2009 ident: 10.1016/j.bbagen.2017.06.008_bb0305 article-title: A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2008.12.002 contributor: fullname: Nakagawa – volume: 7 year: 2012 ident: 10.1016/j.bbagen.2017.06.008_bb0215 article-title: Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier publication-title: PLoS One doi: 10.1371/journal.pone.0039565 contributor: fullname: Dohgu – volume: 42 start-page: 695 year: 2015 ident: 10.1016/j.bbagen.2017.06.008_bb0130 article-title: Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake publication-title: Nucl. Med. Biol. doi: 10.1016/j.nucmedbio.2015.03.003 contributor: fullname: Rotman – volume: 249 start-page: 165 year: 1997 ident: 10.1016/j.bbagen.2017.06.008_bb0265 article-title: Concentration measurement of unpurified proteins using biosensor technology under conditions of partial mass transport limitation publication-title: Anal. Biochem. doi: 10.1006/abio.1997.2183 contributor: fullname: Richalet-Secordel – volume: 22 start-page: 67 year: 1993 ident: 10.1016/j.bbagen.2017.06.008_bb0370 article-title: Transcytosis of protein through the mammalian cerebral epithelium and endothelium. II. Adsorptive transcytosis of WGA-HRP and the blood-brain and brain-blood barriers publication-title: J. Neurocytol. doi: 10.1007/BF01181571 contributor: fullname: Villegas – volume: 244 start-page: 312 year: 1998 ident: 10.1016/j.bbagen.2017.06.008_bb0310 article-title: Hydrocortisone reinforces the blood-brain barrier properties in a serum free cell culture system publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1997.8051 contributor: fullname: Hoheisel – volume: 7 year: 2012 ident: 10.1016/j.bbagen.2017.06.008_bb0390 article-title: Analysis and functional consequences of increased Fab-sialylation of intravenous immunoglobulin (IVIG) after lectin fractionation publication-title: PLoS One doi: 10.1371/journal.pone.0037243 contributor: fullname: Kasermann – volume: 61 start-page: PL119 year: 1997 ident: 10.1016/j.bbagen.2017.06.008_bb0200 article-title: HIV-1 protein gp120 crosses the blood-brain barrier: role of adsorptive endocytosis publication-title: Life Sci. doi: 10.1016/S0024-3205(97)00597-3 contributor: fullname: Banks – volume: 20 start-page: 838 year: 2015 ident: 10.1016/j.bbagen.2017.06.008_bb0095 article-title: Bispecific antibodies publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2015.02.008 contributor: fullname: Kontermann – volume: 8 start-page: 36 year: 2013 ident: 10.1016/j.bbagen.2017.06.008_bb0010 article-title: Immunotherapy for Alzheimer's disease: hoops and hurdles publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-8-36 contributor: fullname: Lemere – volume: 47 start-page: 226 year: 2006 ident: 10.1016/j.bbagen.2017.06.008_bb0025 article-title: A comparative study of initial use of intravenous immunoglobulin and prednisolone treatments in childhood idiopathic thrombocytopenic purpur publication-title: Acta Paediatr. Taiwan. contributor: fullname: Ou – volume: 12 start-page: 807 year: 1995 ident: 10.1016/j.bbagen.2017.06.008_bb0150 article-title: Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate publication-title: Pharm. Res. doi: 10.1023/A:1016244500596 contributor: fullname: Pardridge – volume: 10 year: 2015 ident: 10.1016/j.bbagen.2017.06.008_bb0235 article-title: Anti-abeta oligomer IgG and surface sialic acid in intravenous immunoglobulin: measurement and correlation with clinical outcomes in Alzheimer's disease treatment publication-title: PLoS One doi: 10.1371/journal.pone.0120420 contributor: fullname: Kwon – volume: 481 start-page: 43 year: 2015 ident: 10.1016/j.bbagen.2017.06.008_bb0230 article-title: Kinetic analysis of IgG antibodies to beta-amyloid oligomers with surface plasmon resonance publication-title: Anal. Biochem. doi: 10.1016/j.ab.2015.03.032 contributor: fullname: Crisostomo – volume: 12 start-page: 223 year: 2015 ident: 10.1016/j.bbagen.2017.06.008_bb0320 article-title: Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit publication-title: J. Neuroinflammation doi: 10.1186/s12974-015-0434-1 contributor: fullname: Banks – volume: 278 start-page: 11612 year: 2003 ident: 10.1016/j.bbagen.2017.06.008_bb0250 article-title: In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M210207200 contributor: fullname: Stine – volume: 25 start-page: 11495 year: 2005 ident: 10.1016/j.bbagen.2017.06.008_bb0165 article-title: IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal fc receptor publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3697-05.2005 contributor: fullname: Deane – volume: 291 start-page: 2367 year: 2004 ident: 10.1016/j.bbagen.2017.06.008_bb0020 article-title: Intravenous immunoglobulin in autoimmune neuromuscular diseases publication-title: JAMA doi: 10.1001/jama.291.19.2367 contributor: fullname: Dalakas – volume: 287 start-page: 1279 year: 2000 ident: 10.1016/j.bbagen.2017.06.008_bb0180 article-title: Convergent solutions to binding at a protein-protein interface publication-title: Science doi: 10.1126/science.287.5456.1279 contributor: fullname: DeLano – volume: 85 start-page: 632 year: 1988 ident: 10.1016/j.bbagen.2017.06.008_bb0195 article-title: Transcytotic pathway for blood-borne protein through the blood-brain barrier publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.85.2.632 contributor: fullname: Broadwell – volume: 313 start-page: 670 year: 2006 ident: 10.1016/j.bbagen.2017.06.008_bb0380 article-title: Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation publication-title: Science doi: 10.1126/science.1129594 contributor: fullname: Kaneko – volume: 12 start-page: 233 year: 2013 ident: 10.1016/j.bbagen.2017.06.008_bb0070 article-title: Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer's disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(13)70014-0 contributor: fullname: Dodel – volume: 11 start-page: 553 year: 2009 ident: 10.1016/j.bbagen.2017.06.008_bb0190 article-title: Investigation of the influence of FcRn on the distribution of IgG to the brain publication-title: AAPS J. doi: 10.1208/s12248-009-9129-9 contributor: fullname: Garg – volume: 75 start-page: 1472 year: 2004 ident: 10.1016/j.bbagen.2017.06.008_bb0045 article-title: Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.2003.033399 contributor: fullname: Dodel – volume: 20 start-page: 541 year: 2005 ident: 10.1016/j.bbagen.2017.06.008_bb0115 article-title: The F(ab)′2 fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2005.04.007 contributor: fullname: Tamura – volume: 29 start-page: 167 year: 2005 ident: 10.1016/j.bbagen.2017.06.008_bb0035 article-title: Intravenous immunoglobulin in immunodeficiency states: state of the art publication-title: Clin Rev Allergy Immunol doi: 10.1385/CRIAI:29:3:167 contributor: fullname: Toubi – ident: 10.1016/j.bbagen.2017.06.008_bb0065 contributor: fullname: Kyhos – volume: 277 start-page: 24466 year: 2002 ident: 10.1016/j.bbagen.2017.06.008_bb0285 article-title: Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia publication-title: J. Biol. Chem. doi: 10.1074/jbc.M202833200 contributor: fullname: Angata – volume: 102 start-page: 420 year: 2007 ident: 10.1016/j.bbagen.2017.06.008_bb0110 article-title: In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2007.04591.x contributor: fullname: Poduslo – volume: 449 start-page: 240 year: 2009 ident: 10.1016/j.bbagen.2017.06.008_bb0225 article-title: Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2008.08.083 contributor: fullname: Bacher – volume: 10 start-page: 455 year: 2008 ident: 10.1016/j.bbagen.2017.06.008_bb0345 article-title: CNS delivery via adsorptive transcytosis publication-title: AAPS J. doi: 10.1208/s12248-008-9055-2 contributor: fullname: Herve – volume: 80 start-page: 4007 year: 2008 ident: 10.1016/j.bbagen.2017.06.008_bb0270 article-title: Surface plasmon resonance study of protein-carbohydrate interactions using biotinylated sialosides publication-title: Anal. Chem. doi: 10.1021/ac702566e contributor: fullname: Linman – volume: 62 start-page: 2404 year: 1994 ident: 10.1016/j.bbagen.2017.06.008_bb0360 article-title: Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin, and albumin: pharmacokinetic and morphological assessments publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.1994.62062404.x contributor: fullname: Banks – volume: 23 start-page: 213 year: 2002 ident: 10.1016/j.bbagen.2017.06.008_bb0005 article-title: The public health impact of Alzheimer's disease, 2000–2050: potential implication of treatment advances publication-title: Annu. Rev. Public Health doi: 10.1146/annurev.publhealth.23.100901.140525 contributor: fullname: Sloane – volume: 97 start-page: 127 issue: Pt 1 year: 1990 ident: 10.1016/j.bbagen.2017.06.008_bb0205 article-title: Adsorptive endocytosis and membrane recycling by cultured primary bovine brain microvessel endothelial cell monolayers publication-title: J. Cell Sci. doi: 10.1242/jcs.97.1.127 contributor: fullname: Raub – volume: 24 start-page: 1682 year: 2010 ident: 10.1016/j.bbagen.2017.06.008_bb0295 article-title: C5a alters blood-brain barrier integrity in experimental lupus publication-title: FASEB J. doi: 10.1096/fj.09-138834 contributor: fullname: Jacob – volume: 19 start-page: 958 year: 2009 ident: 10.1016/j.bbagen.2017.06.008_bb0240 article-title: Glycosylation profiles of epitope-specific anti-beta-amyloid antibodies revealed by liquid chromatography-mass spectrometry publication-title: Glycobiology doi: 10.1093/glycob/cwp038 contributor: fullname: Perdivara – volume: 95 start-page: 1201 year: 2005 ident: 10.1016/j.bbagen.2017.06.008_bb0155 article-title: The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2005.03463.x contributor: fullname: Abulrob – volume: 249 start-page: 153 year: 1997 ident: 10.1016/j.bbagen.2017.06.008_bb0260 article-title: Theoretical analysis of protein concentration determination using biosensor technology under conditions of partial mass transport limitation publication-title: Anal. Biochem. doi: 10.1006/abio.1997.2182 contributor: fullname: Christensen – volume: 5 start-page: 682 year: 2014 ident: 10.1016/j.bbagen.2017.06.008_bb0335 article-title: Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics publication-title: Front. Immunol. contributor: fullname: Sand – volume: 26 start-page: 5340 year: 2006 ident: 10.1016/j.bbagen.2017.06.008_bb0220 article-title: Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0695-06.2006 contributor: fullname: Wilcock – volume: 285 start-page: 4826 year: 2010 ident: 10.1016/j.bbagen.2017.06.008_bb0325 article-title: Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.081828 contributor: fullname: Andersen – volume: 1253 start-page: 170 year: 2012 ident: 10.1016/j.bbagen.2017.06.008_bb0375 article-title: Novel roles for the IgG Fc glycan publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2011.06305.x contributor: fullname: Anthony – volume: 46 start-page: 247 year: 2001 ident: 10.1016/j.bbagen.2017.06.008_bb0135 article-title: Delivery of peptides and proteins through the blood-brain barrier publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/S0169-409X(00)00139-3 contributor: fullname: Bickel – volume: 33 start-page: 67 year: 2010 ident: 10.1016/j.bbagen.2017.06.008_bb0060 article-title: Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease publication-title: Clin. Neuropharmacol. doi: 10.1097/WNF.0b013e3181cb577a contributor: fullname: Siemers – volume: 21 start-page: 988 year: 2011 ident: 10.1016/j.bbagen.2017.06.008_bb0280 article-title: Effective glycoanalysis with Maackia amurensis lectins requires a clear understanding of their binding specificities publication-title: Glycobiology doi: 10.1093/glycob/cwr080 contributor: fullname: Geisler – volume: 8 year: 2013 ident: 10.1016/j.bbagen.2017.06.008_bb0385 article-title: Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin g publication-title: PLoS One doi: 10.1371/journal.pone.0081448 contributor: fullname: Ogata – volume: 369 start-page: 134 year: 2013 ident: 10.1016/j.bbagen.2017.06.008_bb0040 article-title: Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1305133 contributor: fullname: Hamid – volume: 39 start-page: 114 year: 2006 ident: 10.1016/j.bbagen.2017.06.008_bb0030 article-title: Effect of regular intravenous immunoglobulin therapy on prevention of pneumonia in patients with common variable immunodeficiency publication-title: J. Microbiol. Immunol. Infect. contributor: fullname: Pourpak – volume: 81 start-page: 203 year: 2002 ident: 10.1016/j.bbagen.2017.06.008_bb0365 article-title: Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2002.00840.x contributor: fullname: Schlachetzki – volume: 23 start-page: 2223 year: 2002 ident: 10.1016/j.bbagen.2017.06.008_bb0100 article-title: Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease publication-title: Peptides doi: 10.1016/S0196-9781(02)00261-9 contributor: fullname: Banks – volume: 292 start-page: 1048 year: 2000 ident: 10.1016/j.bbagen.2017.06.008_bb0145 article-title: Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Lee – volume: 1534 start-page: 13 year: 2013 ident: 10.1016/j.bbagen.2017.06.008_bb0175 article-title: Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn publication-title: Brain Res. doi: 10.1016/j.brainres.2013.08.035 contributor: fullname: Cooper – volume: 6 start-page: 916 year: 2000 ident: 10.1016/j.bbagen.2017.06.008_bb0055 article-title: Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease publication-title: Nat. Med. doi: 10.1038/78682 contributor: fullname: Bard – volume: 6 start-page: 502 year: 2014 ident: 10.1016/j.bbagen.2017.06.008_bb0185 article-title: The effect of the neonatal Fc receptor on human IgG biodistribution in mice publication-title: MAbs doi: 10.4161/mabs.27765 contributor: fullname: Chen – volume: 93 start-page: 279 year: 2005 ident: 10.1016/j.bbagen.2017.06.008_bb0300 article-title: Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2004.03020.x contributor: fullname: Perriere – volume: 28 start-page: 4764 year: 2014 ident: 10.1016/j.bbagen.2017.06.008_bb0125 article-title: A novel platform for engineering blood-brain barrier-crossing bispecific biologics publication-title: FASEB J. doi: 10.1096/fj.14-253369 contributor: fullname: Farrington – volume: 370 start-page: 322 year: 2014 ident: 10.1016/j.bbagen.2017.06.008_bb0080 article-title: Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1304839 contributor: fullname: Salloway – volume: 6 start-page: 7 year: 2013 ident: 10.1016/j.bbagen.2017.06.008_bb0350 article-title: The blood-brain barrier: an engineering perspective publication-title: Front. Neuroeng. doi: 10.3389/fneng.2013.00007 contributor: fullname: Wong – volume: 114 start-page: 168 year: 2001 ident: 10.1016/j.bbagen.2017.06.008_bb0170 article-title: Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier publication-title: J. Neuroimmunol. doi: 10.1016/S0165-5728(01)00242-9 contributor: fullname: Zhang – volume: 64 start-page: 629 year: 2012 ident: 10.1016/j.bbagen.2017.06.008_bb0090 article-title: Drug delivery to the brain in Alzheimer's disease: consideration of the blood-brain barrier publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2011.12.005 contributor: fullname: Banks – volume: 24 start-page: 591 year: 2007 ident: 10.1016/j.bbagen.2017.06.008_bb0275 article-title: Differential affinities of Erythrina cristagalli lectin (ECL) toward monosaccharides and polyvalent mammalian structural units publication-title: Glycoconj. J. doi: 10.1007/s10719-007-9063-y contributor: fullname: Wu – volume: 6 year: 2011 ident: 10.1016/j.bbagen.2017.06.008_bb0160 article-title: A carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain publication-title: PLoS One doi: 10.1371/journal.pone.0028881 contributor: fullname: Sarkar – volume: 30 start-page: 1728 year: 2009 ident: 10.1016/j.bbagen.2017.06.008_bb0050 article-title: 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2007.12.021 contributor: fullname: Relkin – volume: 5 year: 2010 ident: 10.1016/j.bbagen.2017.06.008_bb0105 article-title: Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease publication-title: PLoS One doi: 10.1371/journal.pone.0010549 contributor: fullname: Jordao – volume: 170 start-page: 769 year: 2005 ident: 10.1016/j.bbagen.2017.06.008_bb0340 article-title: Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters publication-title: J. Cell Biol. doi: 10.1083/jcb.200506103 contributor: fullname: Tagawa – volume: 34 start-page: 36 year: 2016 ident: 10.1016/j.bbagen.2017.06.008_bb0140 article-title: Antibody approaches to treat brain diseases publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2015.10.005 contributor: fullname: Neves – volume: 428 start-page: 30 year: 2016 ident: 10.1016/j.bbagen.2017.06.008_bb0355 article-title: Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines publication-title: J. Immunol. Methods doi: 10.1016/j.jim.2015.11.009 contributor: fullname: Mimura – volume: 370 start-page: 311 year: 2014 ident: 10.1016/j.bbagen.2017.06.008_bb0075 article-title: Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1312889 contributor: fullname: Doody – volume: 85 start-page: 734 year: 2005 ident: 10.1016/j.bbagen.2017.06.008_bb0290 article-title: Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium publication-title: Lab. Investig. doi: 10.1038/labinvest.3700281 contributor: fullname: Coisne – volume: 2013 start-page: 193 year: 2013 ident: 10.1016/j.bbagen.2017.06.008_bb0120 article-title: In vivo applications of single chain Fv (variable domain) (scFv) fragments publication-title: Antibodies doi: 10.3390/antib2020193 contributor: fullname: Monnier – volume: 537 start-page: 50 year: 2016 ident: 10.1016/j.bbagen.2017.06.008_bb0085 article-title: The antibody aducanumab reduces Abeta plaques in Alzheimer's disease publication-title: Nature doi: 10.1038/nature19323 contributor: fullname: Sevigny – volume: 182 start-page: 319 year: 1989 ident: 10.1016/j.bbagen.2017.06.008_bb0255 article-title: Calculation of protein extinction coefficients from amino acid sequence data publication-title: Anal. Biochem. doi: 10.1016/0003-2697(89)90602-7 contributor: fullname: Gill – volume: 8 start-page: 2858 year: 2008 ident: 10.1016/j.bbagen.2017.06.008_bb0330 article-title: Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides publication-title: Proteomics doi: 10.1002/pmic.200700968 contributor: fullname: Stadlmann – volume: 46 start-page: 860 year: 1999 ident: 10.1016/j.bbagen.2017.06.008_bb0015 article-title: Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease publication-title: Ann. Neurol. doi: 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M contributor: fullname: McLean |
| SSID | ssj0000595 ssj0025309 |
| Score | 2.3632238 |
| Snippet | Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain... BACKGROUNDDrug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain... |
| SourceID | pubmedcentral proquest crossref pubmed elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 2228 |
| SubjectTerms | Alzheimer's disease Animals Antibodies, Monoclonal - analysis Antibodies, Monoclonal - metabolism Blood brain barrier Fab Fc antibody glycosylation Glycosylation Immunoglobulin G - analysis Immunoglobulin G - metabolism Male Mice N-Acetylneuraminic Acid - analysis Sialic acid Surface plasmon resonance |
| Title | Antibody blood-brain barrier efflux is modulated by glycan modification |
| URI | https://dx.doi.org/10.1016/j.bbagen.2017.06.008 https://www.ncbi.nlm.nih.gov/pubmed/28624473 https://search.proquest.com/docview/1911198673 https://pubmed.ncbi.nlm.nih.gov/PMC5557653 |
| Volume | 1861 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxEB6VRIheEARKw6NypV5N6rV3vT5GESUQkUNL1dys9assKpuqTSRy4bfj2UdLAAmJ02r90Foz3nnIn-cDOBI-ehFjLDWFyqhwqqAqKwwN3LBUxpBcFngb-dM8m56Lj4t0sQOT7i4Mwipb29_Y9Npaty2jVpqj67IcneGhXgwnUoabVImYt_ejO0ryHvTHH2bT-b1BTmvyFRxPcUJ3g66GeRkT_1sshMpkXcgTeSb_7qH-jEB_B1L-4plOnsDjNqQk42bVT2HHVwN42JBMbgbwaNJxuj2D9-NqVZql25AGsG6QIIKY4gZ564gP4Wr9nZS35NvSIa2Xd8RsyOXVJsof2xBWVGvyOZyfvPs8mdKWSoFakfEVzZzgPkghQgjHRkgf1WOiq7bBhphCBcallcLaRNn4LWUdC7n13CuWy0Kmlu9Br1pWfh-IyTPrlMucT2Jy5nIjmc8dLzDYUIn3Q6Cd-PR1UzFDd1Cyr7oRt0Zx6xpRlw9BdjLWW5rX0aj_Y-ZhpxId5YgnHUXll-tbzdCEqzyTfAgvGhXdrSXBKzECe-SW8u4GYMHt7Z6q_FIX3k7TmJ2l_OV_r_gV7OJbg1F7Db3Vzdq_iUHNyhzAg7c_2EG7dfE5O72Y_QQD0vrw |
| link.rule.ids | 230,315,783,787,888,4509,24128,27936,27937,45597,45691 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTxsxEB4hoopeEFAoaWnrSr1aYWPven2MItJQIJeCxM1av9qt6AZBIjX_vjP7gKYgVerVXmutGXse8jfzAXySAb2ItY7bQmdcel1wnRWWR2GTVGFIrgqqRr6YZdMr-eU6vd6AcVcLQ7DK1vY3Nr221u3IoJXm4LYsB1_pUQ_DiTShQ6ol5u09jAY03s7e6PRsOns0yGlNvkLfc1rQVdDVMC9r8d5SI9RE1Y08iWfyeQ_1NAL9G0j5h2ea7MB2G1KyUbPrXdgI1R68aEgmV3uwNe443V7B51G1KO3cr1gDWLdEEMFscUe8dSzEeLP8xcp79nPuidYreGZX7NvNCuVPYwQrqjW5D1eTk8vxlLdUCtzJTCx45qUIUUkZYzy2UgVUj0VX7aKLmELFRCinpHND7fBf2vkk5i6IoJNcFSp14gA2q3kVDoHZPHNe-8yHISZnPrcqCbkXBQUbehhCH3gnPnPbdMwwHZTsh2nEbUjcpkbU5X1QnYzNmuYNGvV_rPzYqcSgHOmlo6jCfHlvEjLhOs-U6MPrRkUPexlSSYykGbWmvIcPqOH2-kxVfq8bb6cpZmepePPfO_4AW9PLi3Nzfjo7ewsvaabBqx3B5uJuGd5hgLOw79sD_Bs6u_tB |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Antibody+blood-brain+barrier+efflux+is+modulated+by+glycan+modification&rft.jtitle=Biochimica+et+biophysica+acta.+General+subjects&rft.au=Finke%2C+John+M.&rft.au=Ayres%2C+Kari+R.&rft.au=Brisbin%2C+Ryan+P.&rft.au=Hill%2C+Hali+A.&rft.date=2017-09-01&rft.issn=0304-4165&rft.volume=1861&rft.issue=9&rft.spage=2228&rft.epage=2239&rft_id=info:doi/10.1016%2Fj.bbagen.2017.06.008&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_bbagen_2017_06_008 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-4165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-4165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-4165&client=summon |