Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

• Published in: Cell reports (Cambridge) Vol. 33; no. 13; p. 108566
• Main Authors: Li, Carman Man-Chung, Shapiro, Hana, Tsiobikas, Christina, Selfors, Laura M., Chen, Huidong, Rosenbluth, Jennifer, Moore, Kaitlin, Gupta, Kushali P., Gray, G. Kenneth, Oren, Yaara, Steinbaugh, Michael J., Guerriero, Jennifer L., Pinello, Luca, Regev, Aviv, Brugge, Joan S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.12.2020
• Subjects: aging; endothelial cells; fibroblasts; luminal and myoepithelial cells; macrophages; mammary epithelia and stroma; single-cell RNA-seq; fibroblasts; endothelial cells; macrophages; single-cell RNA-seq; aging; mammary epithelia and stroma; luminal and myoepithelial cells

Aging is closely associated with increased susceptibility to breast cancer, yet there have been limited systematic studies of aging-induced alterations in the mammary gland. Here, we leverage high-throughput single-cell RNA sequencing to generate a detailed transcriptomic atlas of young and aged mur...